2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID
- Product Name
- 2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID
- CAS No.
- 334952-09-9
- Chemical Name
- 2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID
- Synonyms
- 6-CARBOXYOXINDOLE;RARECHEM AL BO 0984;6-Carboxyl-2-oxindole;Intedanib Impurity 30;6-OXINDOLECARBOXYLIC ACID;OXINDOLE-6-CARBOXYLIC ACID;2-Oxindole-6-carboxylic acid;2-Oxyindole-6-carboxylic acid;2-Oxo-indoline-6-carboxylic acid;2-oxo-1,3-dihydroindole-6-carboxylic acid
- CBNumber
- CB5464274
- Molecular Formula
- C9H7NO3
- Formula Weight
- 177.16
- MOL File
- 334952-09-9.mol
2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID Property
- Boiling point:
- 438.1±45.0 °C(Predicted)
- Density
- 1.433±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 3.94±0.20(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C178935
- Product name
- 6-Carboxyoxindole
- Packaging
- 1g
- Price
- $220
- Updated
- 2021/12/16
- Product number
- C178935
- Product name
- 6-Carboxyoxindole
- Packaging
- 100mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- Z1657
- Product name
- 6-Carboxyoxindole
- Packaging
- 1g
- Price
- $103
- Updated
- 2021/12/16
- Product number
- OR910478
- Product name
- 6-Carboxyoxindole
- Purity
- 97%
- Packaging
- 5g
- Price
- $595
- Updated
- 2021/12/16
- Product number
- 123002
- Product name
- 2-Oxindole-6-carboxylicacid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $1386
- Updated
- 2021/12/16
2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID Chemical Properties,Usage,Production
Synthesis
14192-26-8
334952-09-9
General procedure for the synthesis of 2-oxoindoline-6-carboxylic acid from methyl 2-oxoindoline-6-carboxylate: Sodium hydroxide solution (1N, 20 mL) was added to a solution of 2-oxoindoline-6-carboxylic acid methyl ester (2 g, 10.46 mmol, 1.00 equiv) in methanol (20 mL). The reaction mixture was stirred at 80 °C for 2 hours. After completion of the reaction, the mixture was cooled to 30 °C, diluted with 50 mL of water and extracted with dichloromethane (2 x 30 mL). The aqueous phases were combined and the pH was adjusted with aqueous hydrochloric acid (6N) to 2. The precipitated solid was collected by filtration and dried to give the title compound 1.28 g (69% yield) as a brown solid.1H NMR (400 MHz, CDCl3) δ: 12.86 (s, 1H), 10.50 (s, 1H), 7.55 (m, 1H), 7.32-7.30 (m. 2H), 3.56 (s, 2H).
References
[1] Patent: US2015/284327, 2015, A1. Location in patent: Paragraph 0215; 0216
[2] Patent: WO2006/64044, 2006, A1. Location in patent: Page/Page column 21-22
2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID Suppliers
- Tel
- --
- Fax
- --
- mktg@pharmaffiliates.com
- Country
- India
- ProdList
- 6739
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from 2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID manufacturers
- Product
- 6-carboxyoxindole ; 6-Carboxyl-2-oxindole; 2-Oxoindoline-6-carboxylic acid in stock Factory 334952-09-9
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 2-Oxo-2,3-dihydro-1H-indole-6-carboxylic acid
- Supply Ability
- Top 3 production capacity Factory
- Release date
- 2019-04-04
- Product
- 2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID 334952-09-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-03