HOE-140

ChemicalBook > CAS DataBase List > HOE-140

Product Name: HOE-140
CAS No.: 138614-30-9
Chemical Name: HOE-140
Synonyms: Firazyr;CS-1399;HOE 140 Acetate;lcatibant Acetate;Aldeibant acetate;HOE-140 (Icatibant);HOE140; ICATIBANT;HOE 140;HOE 140 SYNTHETIC >99% SELECTIVE B2 BRAD YKIN;H-D-Arg-Arg-Pro-Hyp-Gly-2Thi-Ser-DL-Tic-Oic-Arg-OH.CH3CO2H;colitis,Bradykinin Receptor,inhibit,angiotensin,Icatibant Acetate,HOE140,ulcerative,Icatibant,HOE-140,Inhibitor,HOE 140
CBNumber: CB5497052
Molecular Formula: C59H89N19O13S.C2H4O2
Formula Weight: 1364.59
MOL File: 138614-30-9.mol

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HOE-140 Property

storage temp.: -20°C
solubility: DMSO:65.0(Max Conc. mg/mL);47.63(Max Conc. mM)
Ethanol:0.25(Max Conc. mg/mL);0.18(Max Conc. mM)
PBS (pH 7.2):10.0(Max Conc. mg/mL);7.33(Max Conc. mM)
form: A crystalline solid
color: White to off-white

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H157
Product name: HOE 140
Purity: ≥94%
Packaging: 250μg
Price: $325
Updated: 2024/03/01

Cayman Chemical

Product number: 24083
Product name: Icatibant (acetate)
Purity: ≥98%
Packaging: 500μg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 24083
Product name: Icatibant (acetate)
Purity: ≥98%
Packaging: 1mg
Price: $143
Updated: 2024/03/01

Cayman Chemical

Product number: 24083
Product name: Icatibant (acetate)
Purity: ≥98%
Packaging: 5mg
Price: $435
Updated: 2024/03/01

TRC

Product number: I163750
Product name: IcatibantAcetate
Packaging: 1mg
Price: $140
Updated: 2021/12/16

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HOE-140 Chemical Properties,Usage,Production

Description

Although it is a rare disease, HAE is an autosomal dominant disorder that can be potentially life-threatening when swelling manifests itself within the upper airways. Antagonism of the constitutively expressed B2 receptor, therefore, would not only be beneficial in the treatment of HAE but also find application in inflammatory, allergic, and hyperalgesic disorders.Designed to possess enhanced metabolic stability with the inclusion of five non-proteinogenic amino acids, icatibant is a competitive and selective B2 receptor antagonist (devoid of activity against the inducible B1 receptor) with a K_i of 2.2±0.7 nM, and it is the first downstream targeting agent to receive regulatory approval. It joins purified C1 esterase inhibitor, danazol (an attenuated androgen), and tranexamic acid (an antifibrinolytic agent) as acute and prophylactic treatments for HAE.

Originator

Jerini (Germany)

Uses

Icatibant Acetate is a bradykinin B2 receptor antagonist that has been recently approved for treatment of acute attacks of hereditary angioedema (HAE).

Uses

Antagonist (bradykinin).

Definition

ChEBI: An acetate salt obtained by combining icatibant with acetic acid. Used for the treatment of acute attacks of hereditary angioedema in adult patients.

brand name

Metastat (CollaGenex);Firazyr.

Biochem/physiol Actions

B2 bradykinin receptors are present in the sensory neurons. Activation of B2 receptor by bradykinin is associated with pro-inflammatory, pain producing and cardiovascular responses. HOE-140 is a selective B2 bradykinin receptor antagonist. Presence of HOE-140 suppresses the effects of bradykinin and has been shown to have anti-hyperalgesic response, particularly towards inflammatory pain.

Synthesis

The peptidomimetic is prepared by standard solidphase technology on Wang resin employing Fmoc chemistry. Following trifluoroacetic acid cleavage with appropriate scavengers and HPLC purification, icatibant is ultimately isolated as its acetate salt.

HOE-140 Preparation Products And Raw materials

Raw materials

Preparation Products

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HOE-140 Suppliers

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View Lastest Price from HOE-140 manufacturers

Dorne Chemical Technology co. LTD

Product: HOE-140 138614-30-9
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 100kg
Release date: 2024-03-26

WUHAN FORTUNA CHEMICAL CO., LTD

Product: HOE-140 138614-30-9
Price: US $0.00/g
Min. Order: 1g
Purity: 98%min
Supply Ability: 1000g
Release date: 2023-01-12

Zibo Hangyu Biotechnology Development Co., Ltd

Product: Icatibant acetate 138614-30-9
Price: US $75.00-750.00/kg
Min. Order: 10kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-11-27

138614-30-9, HOE-140Related Search:

Exenatide acetate Octreotide acetate Isoamyl acetate Vinyl acetate Indole-3-acetic acid Ethylenediaminetetraacetic acid Atosiban Secretin Acetate Thymosin beta 4 Gonadorelin acetate Calcitonin salmon HOE 140 HOE-140 H-GLY-PRO-ARG-OH ACETATE SALT H-LEU-ARG-OH 1-(3,4-dihydroisoquinolin-2(1H)-yl)propan-2-amine N-BENZYL-1-(1-PYRROLIDINYL)-2-PROPANAMINE

HOE-140 (Icatibant)

HOE140; ICATIBANT;HOE 140

CS-1399

Firazyr

HOE 140 SYNTHETIC >99% SELECTIVE B2 BRAD YKIN

d-arg-l-arg-l-pro-l-hyp-gly-l-(2-thienyl)ala-l-ser-d-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-l-(2α,3β,7aβ)-octahydro-1h-indole-2-carbonyl-l-arg

Icatibant acetate, D-Arg-L-Arg-L-Pro-L-Hyp-Gly-L-(2-thienyl)Ala-L-Ser-D-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-(2α,3β,7aβ)-octahydro-1H-indole-2-carbonyl-L-Arg

HOE 140 Acetate

lcatibant Acetate

(2S)-2-[[(3aS,7aS)-1-[2-[(2S)-2-[[(2S)-2-[[2-[[(4R)-1-[1-[2-[[(2R)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]-4-hydroxy-pyrrolidine-2-carbonyl]amino]acetyl]amino]-3-thiophen-2-yl-propanoyl]amino]-3-hydroxy-propanoyl]3,4-dihydro-1H-isoquinoline-3-carbonyl]2,3,3a,4,5,6,7,7a-octahydroindole-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid

colitis,Bradykinin Receptor,inhibit,angiotensin,Icatibant Acetate,HOE140,ulcerative,Icatibant,HOE-140,Inhibitor,HOE 140

Aldeibant acetate

H-D-Arg-Arg-Pro-Hyp-Gly-2Thi-Ser-DL-Tic-Oic-Arg-OH.CH3CO2H

138614-30-9

C59H89N19O13SxC2H4O2

C59H89N19O13S

C59H90N20O12SC2H4O2n