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HOE-140

Product Name
HOE-140
CAS No.
138614-30-9
Chemical Name
HOE-140
Synonyms
Firazyr;CS-1399;HOE 140 Acetate;lcatibant Acetate;Aldeibant acetate;HOE-140 (Icatibant);HOE140; ICATIBANT;HOE 140;HOE 140 SYNTHETIC >99% SELECTIVE B2 BRAD YKIN;H-D-Arg-Arg-Pro-Hyp-Gly-2Thi-Ser-DL-Tic-Oic-Arg-OH.CH3CO2H;colitis,Bradykinin Receptor,inhibit,angiotensin,Icatibant Acetate,HOE140,ulcerative,Icatibant,HOE-140,Inhibitor,HOE 140
CBNumber
CB5497052
Molecular Formula
C59H89N19O13S.C2H4O2
Formula Weight
1364.59
MOL File
138614-30-9.mol
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HOE-140 Property

storage temp. 
-20°C
solubility 
DMSO:65.0(Max Conc. mg/mL);47.63(Max Conc. mM)
Ethanol:0.25(Max Conc. mg/mL);0.18(Max Conc. mM)
PBS (pH 7.2):10.0(Max Conc. mg/mL);7.33(Max Conc. mM)
form 
A crystalline solid
color 
White to off-white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H157
Product name
HOE 140
Purity
≥94%
Packaging
250μg
Price
$325
Updated
2024/03/01
Cayman Chemical
Product number
24083
Product name
Icatibant (acetate)
Purity
≥98%
Packaging
500μg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
24083
Product name
Icatibant (acetate)
Purity
≥98%
Packaging
1mg
Price
$143
Updated
2024/03/01
Cayman Chemical
Product number
24083
Product name
Icatibant (acetate)
Purity
≥98%
Packaging
5mg
Price
$435
Updated
2024/03/01
TRC
Product number
I163750
Product name
IcatibantAcetate
Packaging
1mg
Price
$140
Updated
2021/12/16
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HOE-140 Chemical Properties,Usage,Production

Description

Although it is a rare disease, HAE is an autosomal dominant disorder that can be potentially life-threatening when swelling manifests itself within the upper airways. Antagonism of the constitutively expressed B2 receptor, therefore, would not only be beneficial in the treatment of HAE but also find application in inflammatory, allergic, and hyperalgesic disorders.Designed to possess enhanced metabolic stability with the inclusion of five non-proteinogenic amino acids, icatibant is a competitive and selective B2 receptor antagonist (devoid of activity against the inducible B1 receptor) with a Ki of 2.2±0.7 nM, and it is the first downstream targeting agent to receive regulatory approval. It joins purified C1 esterase inhibitor, danazol (an attenuated androgen), and tranexamic acid (an antifibrinolytic agent) as acute and prophylactic treatments for HAE.

Originator

Jerini (Germany)

Uses

Icatibant Acetate is a bradykinin B2 receptor antagonist that has been recently approved for treatment of acute attacks of hereditary angioedema (HAE).

Uses

Antagonist (bradykinin).

Definition

ChEBI: An acetate salt obtained by combining icatibant with acetic acid. Used for the treatment of acute attacks of hereditary angioedema in adult patients.

brand name

Metastat (CollaGenex);Firazyr.

Biochem/physiol Actions

B2 bradykinin receptors are present in the sensory neurons. Activation of B2 receptor by bradykinin is associated with pro-inflammatory, pain producing and cardiovascular responses. HOE-140 is a selective B2 bradykinin receptor antagonist. Presence of HOE-140 suppresses the effects of bradykinin and has been shown to have anti-hyperalgesic response, particularly towards inflammatory pain.

Synthesis

The peptidomimetic is prepared by standard solidphase technology on Wang resin employing Fmoc chemistry. Following trifluoroacetic acid cleavage with appropriate scavengers and HPLC purification, icatibant is ultimately isolated as its acetate salt.

HOE-140 Preparation Products And Raw materials

Raw materials

Preparation Products

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HOE-140 Suppliers

China 111 India 6 South Korea 1 Switzerland 1 United Kingdom 2 United States 8 Global 129
SIGMA-RBI
Tel
--
Fax
--
Country
Switzerland
ProdList
6896
Advantage
91
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View Lastest Price from HOE-140 manufacturers

Dorne Chemical Technology co. LTD
Product
HOE-140 138614-30-9
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
100kg
Release date
2024-03-26
WUHAN FORTUNA CHEMICAL CO., LTD
Product
HOE-140 138614-30-9
Price
US $0.00/g
Min. Order
1g
Purity
98%min
Supply Ability
1000g
Release date
2023-01-12
Zibo Hangyu Biotechnology Development Co., Ltd
Product
Icatibant acetate 138614-30-9
Price
US $75.00-750.00/kg
Min. Order
10kg
Purity
0.99
Supply Ability
20tons
Release date
2023-11-27

138614-30-9, HOE-140Related Search:

Exenatide acetate Octreotide acetate Isoamyl acetate Vinyl acetate Indole-3-acetic acid Ethylenediaminetetraacetic acid Atosiban Secretin Acetate Thymosin beta 4 Gonadorelin acetate Calcitonin salmon HOE 140 HOE-140 H-GLY-PRO-ARG-OH ACETATE SALT H-LEU-ARG-OH 1-(3,4-dihydroisoquinolin-2(1H)-yl)propan-2-amine N-BENZYL-1-(1-PYRROLIDINYL)-2-PROPANAMINE

  • HOE-140 (Icatibant)
  • HOE140; ICATIBANT;HOE 140
  • CS-1399
  • Firazyr
  • HOE 140 SYNTHETIC >99% SELECTIVE B2 BRAD YKIN
  • d-arg-l-arg-l-pro-l-hyp-gly-l-(2-thienyl)ala-l-ser-d-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-l-(2α,3β,7aβ)-octahydro-1h-indole-2-carbonyl-l-arg
  • Icatibant acetate, D-Arg-L-Arg-L-Pro-L-Hyp-Gly-L-(2-thienyl)Ala-L-Ser-D-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-(2α,3β,7aβ)-octahydro-1H-indole-2-carbonyl-L-Arg
  • HOE 140 Acetate
  • lcatibant Acetate
  • (2S)-2-[[(3aS,7aS)-1-[2-[(2S)-2-[[(2S)-2-[[2-[[(4R)-1-[1-[2-[[(2R)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]-4-hydroxy-pyrrolidine-2-carbonyl]amino]acetyl]amino]-3-thiophen-2-yl-propanoyl]amino]-3-hydroxy-propanoyl]3,4-dihydro-1H-isoquinoline-3-carbonyl]2,3,3a,4,5,6,7,7a-octahydroindole-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid
  • colitis,Bradykinin Receptor,inhibit,angiotensin,Icatibant Acetate,HOE140,ulcerative,Icatibant,HOE-140,Inhibitor,HOE 140
  • Aldeibant acetate
  • H-D-Arg-Arg-Pro-Hyp-Gly-2Thi-Ser-DL-Tic-Oic-Arg-OH.CH3CO2H
  • 138614-30-9
  • C59H89N19O13SxC2H4O2
  • C59H89N19O13S
  • C59H90N20O12SC2H4O2n