ChemicalBook > CAS DataBase List > Dermorphin

Dermorphin

Structure

Product Name: Dermorphin
CAS No.: 77614-16-5
Chemical Name: Dermorphin
Synonyms: DERMORPHIN;Dermorphin 5mg;Dermorphin HAc;Dermorphin Powder;DERMORPHIN ACETATE;dermorphin/DERMORPHIN ACETATE;Dermorphin trifluoroacetate salt;L-Tyr-D-Ala-L-Phe-Gly-L-Tyr-L-Pro-L-Ser-NH2;Tyrosyl-alanyl-phenylalanyl-glycyl-tyrosyl-prolyl-serinamide;(2S)-1-[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenyl-propanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]-N-[(1S)-1-carbamoyl-2-hydro
CBNumber: CB5498044
Molecular Formula: C40H50N8O10
Formula Weight: 802.87
MOL File: 77614-16-5.mol

Less

Dermorphin Property

Melting point:: 157-159 °C
Boiling point:: 1323.8±65.0 °C(Predicted)
Density: 1.363±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO
pka: 9.83±0.15(Predicted)
form: powder
color: white to off-white
Sequence: H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2
InChI: InChI=1S/C40H50N8O10/c1-23(44-37(55)29(41)18-25-9-13-27(50)14-10-25)36(54)46-30(19-24-6-3-2-4-7-24)38(56)43-21-34(52)45-31(20-26-11-15-28(51)16-12-26)40(58)48-17-5-8-33(48)39(57)47-32(22-49)35(42)53/h2-4,6-7,9-16,23,29-33,49-51H,5,8,17-22,41H2,1H3,(H2,42,53)(H,43,56)(H,44,55)(H,45,52)(H,46,54)(H,47,57)/t23-,29+,30+,31+,32+,33+/m1/s1
InChIKey: FHZPGIUBXYVUOY-VWGYHWLBSA-N
SMILES: C(N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N)(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](C)NC(=O)[C@@H](N)CC1C=CC(O)=CC=1)CC1C=CC=CC=1)CC1C=CC(O)=CC=1

Less

Safety

WGK Germany: 3

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FD108711
Product name: Dermorphin
Packaging: 25mg
Price: $55
Updated: 2021/12/16

ChemScene

Product number: CS-7103
Product name: Dermorphin
Purity: 99.64%
Packaging: 1mg
Price: $72
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD108711
Product name: Dermorphin
Packaging: 50mg
Price: $90
Updated: 2021/12/16

ChemScene

Product number: CS-7103
Product name: Dermorphin
Purity: 99.64%
Packaging: 5mg
Price: $132
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD108711
Product name: Dermorphin
Packaging: 100mg
Price: $140
Updated: 2021/12/16

Less

Dermorphin Chemical Properties,Usage,Production

Structure

Dermorphin does not contain the common N-terminal sequence for the traditional endogenous opioid peptides (Tyr–Gly–Gly–Phe), and its sequence is completely different from those of the endomorphins, which were identified as endogenous μ-opioid peptides that also do not contain the common sequence. Interestingly, DM contains D-alanine (a D-isomer amino acid) in its sequence. The primary structure of dermorphin is YDAFGYPS-NH2.

Description

Dermorphin was first isolated from the skin of the skin of South American frogs of the genus Phyllomedusa. It is a high potency natural opiate peptide that binds selectively to mu-opioid receptors.

Uses

A mu-opioid receptor agonist

Definition

ChEBI: Dermorphin is an oligopeptide.

Side effects

Like μ-opiate agonists, dermorphins produce antinociception and also catalepsy, respiratory depression, constipation, tolerance, and dependence, although at a lower degree than morphine does[1].

in vitro

Dermorphin, a peptide isolated from the skin of Phyllomedusa frogs and the peptide receptor (NOP) component by the endogenous agonist nociceptin/orphanin FQ (N/OFQ). In displacement binding studies at CHOhMu, Dermorphin and DeNo displac the binding of [3H]-DPN in a concentration dependent and saturable manner. Dermorphin displays an affinity of 7.17, while N/OFQ fails to displace [3H]-DPN at the Delta receptor. Dermorphin and DeNo stimulate the binding of GTPγ[35S] in a concentration dependent and saturable manner at the Mu receptor.

References

[1] Negri, L. P. Melchiorri and R. Lattanzi. “Opioid and Bv8 Peptides.”Handbook of Biologically Active Peptides (Second Edition) 2013:376-383.

Dermorphin Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Dermorphin Suppliers

China 141 India 1 Switzerland 1 United Kingdom 1 United States 8 USA 1 Global 153

Nanjing TGpeptide Biotechnology Co.,Ltd.

Tel: 18115476705
Email: sales@tgpeptide.com
Country: China
ProdList: 3058
Advantage: 58

Hangzhou Peptidego Biotech Co.,Ltd.

Tel: 0571-87213919
Email: Eric@peptidego.com
Country: China
ProdList: 7408
Advantage: 58

Hangzhou TSurgeX Pharmaceutical Technology Co., Ltd

Tel: +86-13393959797 +86-13393959797
Email: master@tsurgex.com
Country: China
ProdList: 45
Advantage: 58

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9637
Advantage: 58

Shanghai Synchem Pharma Co., ltd

Tel: 21-619849051-1 18521059765
Email: synchempharma@aliyun.com
Country: China
ProdList: 6468
Advantage: 55

Shanghai Haozhixiang Biotechnology Co., Ltd

Tel: 526763801 13301653310
Fax: +86-21-51619052
Email: 526763801@qq.com
Country: China
ProdList: 9274
Advantage: 55

Nanjing Leon Biological Technology Co., Ltd.

Tel: 17705183659
Fax: 84523390
Email: sales@njleonbiotech.com
Country: China
ProdList: 5501
Advantage: 55

Nanjing Peptide Biotech Ltd.

Tel: 025-58361106-805 15951641583
Fax: 025-58361106-806
Email: zhao.xu@njpeptide.com
Country: China
ProdList: 9979
Advantage: 55

Aikon International Limited

Tel: 025-58851090 15955137747
Fax: (6)02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 15949
Advantage: 58

UHN Shanghai Research & Development Co., Ltd.

Tel: 021-58958002 18930822973
Fax: 021-58958618
Email: sales@uhnshanghai.com
Country: China
ProdList: 1984
Advantage: 58

Sichuan Jisheng Biopharmaceutical Co.,Ltd.

Tel: +86-0833-2598983 +86-18086877136
Fax: +86-833-2598903
Email: Nyx-peptide@jsjpharm.cn
Country: China
ProdList: 308
Advantage: 58

Shanghai Han-Xiang Chemical Co., Ltd.

Tel: 15971444841
Fax: 18327183813
Email: amber@biochempartner.com
Country: China
ProdList: 3061
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

Finetech Industry Limited

Tel: +86-27-8746-5837 +8619945049750
Fax: 86 27 87772287
Email: info@finetechnology-ind.com
Country: China
ProdList: 9629
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10473
Advantage: 58

Wuhan wingroup Pharmaceutical Co., Ltd

Tel: +86-13296627870; +8613296627870
Fax: 0086-27-87819568
Email: info@whwingroup.com
Country: China
ProdList: 695
Advantage: 58

Shanghai Biolang Biotechnology Co., Ltd.

Tel: +86-15970428662 +86-13397199602
Fax: +8613397199602
Email: Niky@biolang.cn
Country: China
ProdList: 515
Advantage: 58

Hubei Ipure Biology Co., Ltd

Tel: +8613367258412
Fax: 18062427325
Email: ada@ipurechemical.com
Country: China
ProdList: 10237
Advantage: 58

Hangzhou Go Top Peptide Biotech

Tel: 0571-88211921
Email: sales1@gotopbio.com
Country: CHINA
ProdList: 2609
Advantage: 58

XI'AN TIANGUANGYUAN BIOTECH CO., LTD.

Tel: +86-029-86333380 +86-18829239519
Fax: 188 2923 9519
Email: sales06@tgybio.com
Country: China
ProdList: 898
Advantage: 58

Baoji Guokang Healthchem Co., Ltd.

Tel: +86-0917-3909592 +86-13892490616
Fax: 09173909592
Email: gksales1@gk-bio.com
Country: China
ProdList: 9209
Advantage: 58

Baoji Guokang Healthchem co.,ltd

Tel: +8615604608665 15604608665
Email: dominicguo@gk-bio.com
Country: CHINA
ProdList: 9414
Advantage: 58

AFINE CHEMICALS LIMITED

Tel: +86-0571-85134551
Fax: 008657185134895
Email: sales@afinechem.com
Country: China
ProdList: 15109
Advantage: 58

Qiuxian Baitai New Material Co., LTD

Tel: +8618330912755
Fax: +8619932103556
Email: sale2@hbyalin.com
Country: China
ProdList: 1658
Advantage: 58

HONG KONG IPURE BIOLOGY CO.,LIMITED

Tel: 86 18062405514 18062405514
Email: ada@ipurechemical.com
Country: CHINA
ProdList: 3461
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30229
Advantage: 58

Chengdu Peter-like Biotechnology Co., Ltd.

Tel: 18108052721
Email: 2850505130@qq.com
Country: China
ProdList: 5167
Advantage: 58

Nanjing chengqimei Biotechnology Co., Ltd

Tel: 19850819832
Email: 2173594524@qq.com
Country: China
ProdList: 2638
Advantage: 58

Neostar United (Changzhou) Industrial Co., Ltd.

Tel: +86-0519-85551759 +8613506123987
Fax: +0086-519-85557389
Email: marketing1@neostarunited.com
Country: China
ProdList: 8830
Advantage: 58

Wuxi Helen Biotechnology Co., Ltd.,

Tel: 0510-85629785 18013409632
Fax: 0510-85625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 14081
Advantage: 58

Ontores Biotech

Tel: 0571-88760729 18072970094
Email: supports@ontorespeptide.com
Country: China
ProdList: 2696
Advantage: 58

Wuhan Wiseman Bioengineering Co.,Ltd

Tel: 13419526507 13419526507
Fax: 027-59506022
Email: 13419526507@163.com
Country: China
ProdList: 2845
Advantage: 58

Hangzhou Go Top Peptide Biotech

Tel: 15397062932
Email: sales1@gotopbio.com
Country: China
ProdList: 2923
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Wuhan Topule

Tel: +86-02787215551 +86-19945035818
Fax: 027-87215551
Email: 2936752263@qq.com
Country: China
ProdList: 7986
Advantage: 58

TCI (Shanghai) Chemical Trading Co., Ltd.

Tel: 021-61109150
Fax: 021-61105897
Email: sales@tcisct.com
Country: China
ProdList: 29668
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

Wuhan DKY Technology Co.,Ltd.

Tel: 027-81302411 15377658509
Email: zs@dkybpc.com
Country: China
ProdList: 1982
Advantage: 58

ChemeGen

Tel: 18818260767
Fax: QQ 3610331285
Email: 2625930290@qq.com
Country: China
ProdList: 6973
Advantage: 58

Wuhan Augda Biotechnology Co., Ltd

Tel: 15071299552
Fax: QQ:262933239
Email: 262933239@qq.com
Country: China
ProdList: 7048
Advantage: 58

Chengdu Jinglin Biotechnology Co., Ltd.

Tel: 17711399154
Email: 3211919385@qq.com
Country: China
ProdList: 1815
Advantage: 58

Shaoxing Junyu Biotechnology Co., LTD

Tel: 0571-0571-88211921 19105816207
Email: sales4@gotopbio.com
Country: China
ProdList: 5144
Advantage: 58

Hubei Weideli Chemical Reagent Co.，Ltd.

Tel: 133-3998-5473 13339985473
Email: C13339985473@163.com
Country: China
ProdList: 4991
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Hangzhou Sinoda Pharmaceutical Technology Co. LTD

Tel: 0571-87213919 17306812703
Email: 3007955328@qq.com
Country: China
ProdList: 6979
Advantage: 58

Hebei ruqi technology co., ltd

Tel: 176-03256889 17603256889
Email: 1123722730@qq.com
Country: China
ProdList: 3376
Advantage: 58

Hubei Wanye Zhongcheng Chemical Reagent Co., Ltd.

Tel: 18671296875
Email: 1205035102@qq.com
Country: China
ProdList: 4302
Advantage: 58

Shanghai Yingxin laboratory equipment Co., Ltd

Tel: 021-021-59178156 15300768757
Email: 359382369@qq.com
Country: China
ProdList: 10674
Advantage: 58

Less

View Lastest Price from Dermorphin manufacturers

Hebei Dangtong Import and export Co LTD

Product: Dermorphin 77614-16-5
Price: US $210.00-15000.00/Grams
Min. Order: 1Grams
Purity: 99%
Supply Ability: 10kg
Release date: 2025-11-05

Shanghai Yimeixin Technology Co., LTD

Product: dermorphin 77614-16-5
Price: US $0.00/box
Min. Order: 1box
Purity: 0.99
Supply Ability: 10tons
Release date: 2025-09-26

Handan City Zechi trading Co., LTD

Product: dermorphin 77614-16-5
Price: US $1.00/g
Min. Order: 5g
Purity: 99
Supply Ability: 777
Release date: 2025-09-11

77614-16-5, DermorphinRelated Search:

PalMitoyl Tripeptide-1 MOTS-c Abaloparatide Irofulven Etelcalcetide Acetyl Hexapeptide-1 GLUCAGON (1-37) (PORCINE) N2-Acetyl-L-lysyl-L-alpha-aspartyl-L-valyl-L-tyrosine Melanotan 1 Palmitoyl Hexapeptide-12 Pexiganan omiganan pentahydrochloride Acetyl Decapeptide-3

DERMORPHIN ACETATE

L-Tyr-D-Ala-L-Phe-Gly-L-Tyr-L-Pro-L-Ser-NH2

Tyrosyl-alanyl-phenylalanyl-glycyl-tyrosyl-prolyl-serinamide

Dermorphin trifluoroacetate salt

Dermorphin Powder

(2S)-N-[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]-1-[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carboxamide

Dermorphin HAc

(2S)-1-[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenyl-propanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]-N-[(1S)-1-carbamoyl-2-hydro

DERMORPHIN

dermorphin/DERMORPHIN ACETATE

Dermorphin 5mg

77614-16-5