Dermorphin

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Structure

Product Name: Dermorphin
CAS No.: 77614-16-5
Chemical Name: Dermorphin
Synonyms: DERMORPHIN;Dermorphin HAc;Dermorphin Powder;DERMORPHIN ACETATE;dermorphin/DERMORPHIN ACETATE;Dermorphin trifluoroacetate salt;L-Tyr-D-Ala-L-Phe-Gly-L-Tyr-L-Pro-L-Ser-NH2;Tyrosyl-alanyl-phenylalanyl-glycyl-tyrosyl-prolyl-serinamide;(2S)-1-[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenyl-propanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]-N-[(1S)-1-carbamoyl-2-hydro;(2S)-N-[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]-1-[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carboxamide
CBNumber: CB5498044
Molecular Formula: C40H50N8O10
Formula Weight: 802.87
MOL File: 77614-16-5.mol

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Dermorphin Property

Melting point:: 157-159 °C
Boiling point:: 1323.8±65.0 °C(Predicted)
Density: 1.363±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO
pka: 9.83±0.15(Predicted)
form: powder
color: white to off-white
Sequence: H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2
InChI: InChI=1S/C40H50N8O10/c1-23(44-37(55)29(41)18-25-9-13-27(50)14-10-25)36(54)46-30(19-24-6-3-2-4-7-24)38(56)43-21-34(52)45-31(20-26-11-15-28(51)16-12-26)40(58)48-17-5-8-33(48)39(57)47-32(22-49)35(42)53/h2-4,6-7,9-16,23,29-33,49-51H,5,8,17-22,41H2,1H3,(H2,42,53)(H,43,56)(H,44,55)(H,45,52)(H,46,54)(H,47,57)/t23-,29+,30+,31+,32+,33+/m1/s1
InChIKey: FHZPGIUBXYVUOY-VWGYHWLBSA-N
SMILES: C(N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N)(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](C)NC(=O)[C@@H](N)CC1C=CC(O)=CC=1)CC1C=CC=CC=1)CC1C=CC(O)=CC=1

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Alfa Aesar

Product number: J62019
Product name: Dermorphin
Packaging: 5mg
Price: $194
Updated: 2021/12/16

ChemScene

Product number: CS-7103
Product name: Dermorphin
Purity: 99.64%
Packaging: 10mg
Price: $216
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD108711
Product name: Dermorphin
Packaging: 250mg
Price: $250
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD108711
Product name: Dermorphin
Packaging: 500mg
Price: $375
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0001209
Product name: DERMORPHIN
Purity: 95.00%
Packaging: 1MG
Price: $427.2
Updated: 2021/12/16

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Dermorphin Chemical Properties,Usage,Production

Structure

Dermorphin does not contain the common N-terminal sequence for the traditional endogenous opioid peptides (Tyr–Gly–Gly–Phe), and its sequence is completely different from those of the endomorphins, which were identified as endogenous μ-opioid peptides that also do not contain the common sequence. Interestingly, DM contains D-alanine (a D-isomer amino acid) in its sequence. The primary structure of dermorphin is YDAFGYPS-NH2.

Description

Dermorphin was first isolated from the skin of the skin of South American frogs of the genus Phyllomedusa. It is a high potency natural opiate peptide that binds selectively to mu-opioid receptors.

Uses

A mu-opioid receptor agonist

Definition

ChEBI: Dermorphin is an oligopeptide.

Side effects

Like μ-opiate agonists, dermorphins produce antinociception and also catalepsy, respiratory depression, constipation, tolerance, and dependence, although at a lower degree than morphine does[1].

in vitro

Dermorphin, a peptide isolated from the skin of Phyllomedusa frogs and the peptide receptor (NOP) component by the endogenous agonist nociceptin/orphanin FQ (N/OFQ). In displacement binding studies at CHOhMu, Dermorphin and DeNo displac the binding of [3H]-DPN in a concentration dependent and saturable manner. Dermorphin displays an affinity of 7.17, while N/OFQ fails to displace [3H]-DPN at the Delta receptor. Dermorphin and DeNo stimulate the binding of GTPγ[35S] in a concentration dependent and saturable manner at the Mu receptor.

References

[1] Negri, L. P. Melchiorri and R. Lattanzi. “Opioid and Bv8 Peptides.”Handbook of Biologically Active Peptides (Second Edition) 2013:376-383.

Dermorphin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Dermorphin manufacturers

Dorne Chemical Technology co. LTD

Product: DERMORPHIN ACETATE 77614-16-5
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 100kg
Release date: 2024-03-26

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Dermorphin 77614-16-5
Price: US $200.00-95.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500000 Pieces Per Year
Release date: 2024-05-09

Hebei Jiafan Trading Company Limited

Product: dermorphin 77614-16-5
Price: US $100.00/box
Min. Order: 1box
Purity: 99%
Supply Ability: 100000000
Release date: 2024-12-10

77614-16-5, DermorphinRelated Search:

PalMitoyl Tripeptide-1 MOTS-c Abaloparatide Irofulven Etelcalcetide Acetyl Hexapeptide-1 GLUCAGON (1-37) (PORCINE) N2-Acetyl-L-lysyl-L-alpha-aspartyl-L-valyl-L-tyrosine Melanotan 1 Palmitoyl Hexapeptide-12 Pexiganan omiganan pentahydrochloride Acetyl Decapeptide-3

DERMORPHIN ACETATE

L-Tyr-D-Ala-L-Phe-Gly-L-Tyr-L-Pro-L-Ser-NH2

Tyrosyl-alanyl-phenylalanyl-glycyl-tyrosyl-prolyl-serinamide

Dermorphin trifluoroacetate salt

Dermorphin Powder

(2S)-N-[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]-1-[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carboxamide

Dermorphin HAc

(2S)-1-[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenyl-propanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]-N-[(1S)-1-carbamoyl-2-hydro

DERMORPHIN

dermorphin/DERMORPHIN ACETATE

77614-16-5