4-(Trifluoromethoxy)benzonitrile
- Product Name
- 4-(Trifluoromethoxy)benzonitrile
- CAS No.
- 332-25-2
- Chemical Name
- 4-(Trifluoromethoxy)benzonitrile
- Synonyms
- uoromethoxy)benzonitriL;p-trifluoromethoxybenonitrile;p-Cyanotrifluoromethoxybenzene;4-(Trifluoromethoxy)benzonitrile;4-(Trifluoromethoxy)cyanobenzene;4-(Trifluoromethyloxy)benzonitrile;Benzonitrile, 4-(trifluoromethoxy)-;4-(Trifluoromethoxy)benzonitrile 98%;4-(TRIFLUOROMETHOXY)BENZONITRILE 98;For trifluoromethoxy benzene nitrile
- CBNumber
- CB5499137
- Molecular Formula
- C8H4F3NO
- Formula Weight
- 187.12
- MOL File
- 332-25-2.mol
4-(Trifluoromethoxy)benzonitrile Property
- Boiling point:
- 192-193 °C(lit.)
- Density
- 1.285 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.452(lit.)
- Flash point:
- 181 °F
- storage temp.
- Inert atmosphere,Room Temperature
- form
- clear liquid
- color
- Colorless to Almost colorless
- BRN
- 2832939
- InChI
- InChI=1S/C8H4F3NO/c9-8(10,11)13-7-3-1-6(5-12)2-4-7/h1-4H
- InChIKey
- XWHIXOMWXCHJPP-UHFFFAOYSA-N
- SMILES
- C(#N)C1=CC=C(OC(F)(F)F)C=C1
- CAS DataBase Reference
- 332-25-2(CAS DataBase Reference)
- EPA Substance Registry System
- Benzonitrile, 4-(trifluoromethoxy)- (332-25-2)
Safety
- Hazard Codes
- Xn,T,Xi
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36/37/39-45
- RIDADR
- 3276
- WGK Germany
- 3
- Hazard Note
- Toxic
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29269090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- T2292
- Product name
- 4-(Trifluoromethoxy)benzonitrile
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $20
- Updated
- 2025/07/31
- Product number
- T2292
- Product name
- 4-(Trifluoromethoxy)benzonitrile
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $45
- Updated
- 2025/07/31
- Product number
- T896570
- Product name
- 4-(Trifluoromethoxy)benzonitrile
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 001405
- Product name
- 4-(Trifluoromethoxy)benzonitrile
- Purity
- 98%
- Packaging
- 1g
- Price
- $9
- Updated
- 2021/12/16
- Product number
- 001405
- Product name
- 4-(Trifluoromethoxy)benzonitrile
- Purity
- 98%
- Packaging
- 5g
- Price
- $10
- Updated
- 2021/12/16
4-(Trifluoromethoxy)benzonitrile Chemical Properties,Usage,Production
Chemical Properties
clear light yellow liquid
General Description
4-(Trifluoromethoxy)benzonitrile serves as an intermediate in the synthesis of fluvoxamine.
Synthesis
1736-74-9
332-25-2
To a 25 mL Schlenk tube equipped with a magnetic stirrer were sequentially added CuCl (0.05 mmol, 5 mol%), DABCO (0.10 mmol, 10 mol%) and 4-HO-TEMPO (0.05 mmol, 5 mol%). Subsequently, a solution of acetonitrile (2 mL) with 4-trifluoromethoxybenzyl alcohol (1 mmol) and ammonia (25-28%, 3 mmol, 3.0 equiv) was added. The reaction mixture was stirred at room temperature for 24 h under balloon protection. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was diluted with water and extracted with ethyl acetate. The organic layers were combined and dried with anhydrous magnesium sulfate. After concentration under reduced pressure, the crude product was purified by column chromatography to give p-trifluoromethoxybenzonitrile.
References
[1] Advanced Synthesis and Catalysis, 2014, vol. 356, # 18, p. 3892 - 3896
[2] Chinese Chemical Letters, 2018, vol. 29, # 3, p. 464 - 466
4-(Trifluoromethoxy)benzonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(Trifluoromethoxy)benzonitrile manufacturers
- Product
- 4-(Trifluoromethoxy)benzonitrile 332-25-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-06-27