ChemicalBook > CAS DataBase List > 4-tert-Butyl-N-(6-chloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide

4-tert-Butyl-N-(6-chloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide

Product Name
4-tert-Butyl-N-(6-chloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide
CAS No.
150727-06-3
Chemical Name
4-tert-Butyl-N-(6-chloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide
Synonyms
Bosentan USP RC A;BenzenesulfonaMide(II);Bosentan EP Impurity-A;Bosentan Intermediate 2;bosentan intermediate(II);Bosentan Related CoMpound A;Bosentan Related Compound 3;Bosentan USP Related CoMpound A;4-tert-Butyl-N-[6-chloro-5-(2-methoxyphenoxy)-2-(2;Bosentan Impurity 10(Bosentan USP Related Compound A)
CBNumber
CB5500707
Molecular Formula
C25H24ClN5O4S
Formula Weight
526.01
MOL File
150727-06-3.mol
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4-tert-Butyl-N-(6-chloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide Property

Melting point:
212-214°C
Boiling point:
676.7±65.0 °C(Predicted)
Density 
1.348±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly, Heated)
form 
Solid
pka
3.67±0.10(Predicted)
color 
White to Pale Yellow
InChI
InChI=1S/C25H24ClN5O4S/c1-25(2,3)16-10-12-17(13-11-16)36(32,33)31-22-20(35-19-9-6-5-8-18(19)34-4)21(26)29-24(30-22)23-27-14-7-15-28-23/h5-15H,1-4H3,(H,29,30,31)
InChIKey
XKISWHVJIZSPSC-UHFFFAOYSA-N
SMILES
C1(S(NC2C(OC3=CC=CC=C3OC)=C(Cl)N=C(C3=NC=CC=N3)N=2)(=O)=O)=CC=C(C(C)(C)C)C=C1
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Safety

HS Code 
2935909550
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C368750
Product name
N-[6-Chloro-5-(2-methoxyphenoxy)-(2,2-bipyrimidine)4-4-yl]-(1,1-dimethylethyl)-benzenesulfonamide
Packaging
100mg
Price
$1070
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC20113
Product name
N-[6-Chloro-5-(2-methoxyphenoxy)-(2,2-bipyrimidine)4-4-yl]-(1,1-dimethylethyl)-benzenesulfonamide
Packaging
25g
Price
$125
Updated
2021/12/16
Matrix Scientific
Product number
093075
Product name
4-tert-Butyl-N-(6-chloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide
Purity
95+%
Packaging
1g
Price
$471
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC20113
Product name
N-[6-Chloro-5-(2-methoxyphenoxy)-(2,2-bipyrimidine)4-4-yl]-(1,1-dimethylethyl)-benzenesulfonamide
Packaging
250g
Price
$500
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC20113
Product name
N-[6-Chloro-5-(2-methoxyphenoxy)-(2,2-bipyrimidine)4-4-yl]-(1,1-dimethylethyl)-benzenesulfonamide
Packaging
10g
Price
$60
Updated
2021/12/16
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4-tert-Butyl-N-(6-chloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide Chemical Properties,Usage,Production

Chemical Properties

Light Pale Yellow Sold

Uses

An intermediate of Bosentan, which is a mixed endothelin receptor antagonist. Bosentan USP Related Compound A.

Synthesis

6292-59-7

150728-13-5

150727-06-3

In a flask equipped with a mechanical stirrer, thermometer, reflux condenser, dropping funnel and heating jacket, a solution of 4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine (105 g) and 4-(tert-butyl)benzenesulfonamide (64.1 g, 0.30 mol) in DMSO (525 mL) was added. To this suspension was added potassium carbonate (83 g, 0.60 mol). The reaction mixture was heated to 100-105 °C under stirring and maintained for 3-4 hours. The reaction progress was monitored by HPLC. After completion of the reaction, the solution was cooled to 20-25 °C. Water (875 mL) was added slowly dropwise over 10-15 minutes and stirring was continued for 1 hour. The precipitated solid was collected by filtration, washed with water (2 x 350 mL) and subsequently transferred to a mortar. Water (800 mL) and concentrated hydrochloric acid (50 mL) were added and stirred for 30 minutes. The precipitated solid was collected by filtration again and washed with water (2 × 200 mL) and acetone (2 × 175 mL) sequentially. The solid was dried under reduced pressure at 40±2 °C for 16-24 h to afford the milky white solid product N-[6-chloro-5-(2-methoxyphenoxy)[2,2'-dipyrimidin]-4-yl]-4-tert-butylbenzenesulfonamide in a yield of 157.8-158.7 g (100% yield).

References

[1] Organic Process Research and Development, 2011, vol. 15, # 6, p. 1382 - 1387
[2] Patent: WO2014/104904, 2014, A1. Location in patent: Page/Page column 13; 14
[3] Organic Process Research and Development, 2013, vol. 17, # 8, p. 1021 - 1026
[4] Patent: WO2012/73135, 2012, A1. Location in patent: Page/Page column 10
[5] Patent: WO2013/57545, 2013, A1. Location in patent: Paragraph 15

4-tert-Butyl-N-(6-chloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-tert-Butyl-N-(6-chloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide Suppliers

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View Lastest Price from 4-tert-Butyl-N-(6-chloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide manufacturers

Moxin Chemicals
Product
Bosentan Impurity 3 150727-06-3
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
95
Supply Ability
100000
Release date
2025-02-12
Career Henan Chemical Co
Product
4-tert-Butyl-N-(6-chloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide 150727-06-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1kg-1000kg
Release date
2020-01-02

150727-06-3, 4-tert-Butyl-N-(6-chloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamideRelated Search:

tert-Butyl peroxyacetate 2-Butoxyethanol p-Anisidine Cyhalofop-butyl 4-Methoxybenzyl alcohol 4-Methoxybenzyl cyanide Diethylene glycol monobutyl ether tert-Butyl acetate 4-Methoxyphenol Anisole (Trifluoromethoxy)benzene tert-Butanol Guaiacol Butyl acetate Buprofezin p-Anisaldehyde Butyl acrylate 4-tert-Butylbenzenesulfonamide

  • N-[6-CHLORO-5-(2-METHOXYPHENOXY)-(2,2-BIPYRIMIDINE)4-4-YL]-(1,1-DIMETHYLETHYL)-BENZENESULFONAMIDE
  • 4-tert-Butyl-N-(6-chloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide
  • n-[6-chloro-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl)benzenesulfonamide
  • N-[6-chloro-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl)-B
  • Benzenesulfonamide, N-[6-chloro-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl)- (bosentan intermediate)
  • Benzenesulfonamide, N-[6-Chloro-5-(2-Methoxyphenoxy)[2,2'-Bi-Pyrimidin]-4-Yl]-4-(1,1-Dimethylethyl)-(9ci)
  • 4-tert-Butyl-N-[6-chloro-5-(2-methoxyphenoxy)-2-(2
  • Benzenesulfonamide, N-[6-chloro-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl)-
  • N-[6-Chloro-5-(2-methoxphenoxy)(2,2-bipyrimidine)4-4-yl]-(1,1-dimethylethyl)-benzenesulfonamide
  • N-[6-Chloro-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl)-(9CI)-benzenesulfonamide
  • 4-tert-Butyl-N-[6-chloro-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide
  • 4-tert-Butyl-N-[6-chloro-5-(2-methoxy-phenoxy) -[2,2']bipyrimidinyl-4-yl]-benzenesulfonamide
  • BenzenesulfonaMide(II)
  • N-[6-CHLORO-5-(2-METHOXYPHENOXY) [2,2-BIPRIMIDIN]-4-(1,1-DIMETHYLETHYL) BENZENESULFONAMIDE
  • Bosentan USP Related CoMpound A
  • Bosentan Related CoMpound A
  • Bosentan Related Compound 3
  • Bosentan Related Compound A (15 mg) (4-(tert-butyl)-N-[6-chloro-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl] benzenesulfonamide)
  • Bosentan USP RC A
  • bosentan intermediate(II)
  • Bosentan USP Related Compound A: 4-(tert-Butyl)-N-[6-chloro-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl]benzenesulfonamide
  • N-[6-chloro-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl)-
  • n-[6-chloro-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-4-(1,1-dimeth
  • N-{6-chloro-5-(2-methoxy phenoxy)[2,2'-bipyrimidin]-4-yl}-4-(1,1-dimethylethyl)benzensulfonamide
  • 4-TERT-BUTYL-N-(6-CHLORO-5- (2-METHOXYPHENOXY)-2,2'- BIPYRIMIDIN-4-YL)BENZENE
  • Bosentan Intermediate 2
  • Benzenesulfonamide, N-[6-chloro-5-(2-methoxyphenoxy)[2,2'-bi...
  • Benzenesulfonamide, N-[6-chloro-5-(2-methoxyphenoxy)[2,2-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl)Q: What is Benzenesulfonamide, N-[6-chloro-5-(2-methoxyphenoxy)[2,2-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl) Q: What is the CAS Number of Benzenesulfonamide, N-[6-chloro-5-(2-methoxyphenoxy)[2,2-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl) Q: What is the storage condition of Benzenesulfonamide, N-[6-chloro-5-(2-methoxyphenoxy)[2,2-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl) Q: What are the applications of Benzenesulfonamide, N-[6-chloro-5-(2-methoxyphenoxy)[2,2-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl)
  • Bosentan Related Compound A (4-(tert-butyl)-N-[6-chloro-5-(2-methoxyphenoxy)-(2,2''-bipyrimidin)-4-y (1076126)
  • Bosentan Impurity 10(Bosentan USP Related Compound A)
  • N - [6-chloro-5- (2-methoxyphenyloxy) [2,2 '- pyrimidine] -4-yl] -4-tert butylbenzenesulfonamide
  • N-[6-Chloro-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl)-Benzenesulfonamide
  • Bosentan EP Impurity-A
  • N-[6-Chloro-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-4-tert-butylbenzenesulfonamide
  • 4-(1,1-dimethylethyl)-N-[6-chloro-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-benzenesulfonamide.
  • 4-tert-Butyl-N-[6-chloro-5-(2-methoxy-phenoxy)-2-(pyrimidin-2-yl)-pyrimidin-4-yl]benzenesulfonamide
  • 150727-06-3
  • C25H26ClN5O4S
  • C25H24ClN5O4S
  • pyrimidine
  • Bases & Related Reagents
  • Intermediates & Fine Chemicals
  • Nucleotides
  • Pharmaceuticals