β-Glycerophosphate disodium salt pentahydrate

Product Name: β-Glycerophosphate disodium salt pentahydrate
CAS No.: 13408-09-8
Chemical Name: β-Glycerophosphate disodium salt pentahydrate
Synonyms: trichloromethyl carbonochloridate;β-Glycerophosphate;β-Glycerophosphate (sodium salt hydrate);SodiuM 1,3-dihydroxypropan-2-yl phosphate;β-Glycerophosphate disodium salt pentahydrate;β-Glycerol phosphate disodium salt pentahydrate;Sodium B Glycerophosphate;Disodium β-glycerol phosphate;beta-Glycerophosphate, 200mM soln;Sodium--glycerophosphate, GR 99%+
CBNumber: CB5502680
Molecular Formula: C3H12NaO7P
Formula Weight: 214.09
MOL File: 13408-09-8.mol

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β-Glycerophosphate disodium salt pentahydrate Property

Melting point:: >300°C
storage temp.: 2-8°C
solubility: H₂O: 0.1 g/mL, clear, colorless
form: White powder
color: Whiteto Off-White
Water Solubility: Soluble in water.
Merck: 14,8622
BRN: 3744328
Stability:: Hygroscopic
InChI: InChI=1S/C3H9O6P.Na.H2O.H/c4-1-3(2-5)9-10(6,7)8;;;/h3-5H,1-2H2,(H2,6,7,8);;1H2;
InChIKey: PEMUISUYOHQFQH-UHFFFAOYSA-L
SMILES: O(P(O)(O)=O)C(CO)CO.[NaH].O

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Safety

WGK Germany: 3
RTECS: UA0600000
F: 10-21
TSCA: Yes
HS Code: 29199000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 35675
Product name: β-Glycerophosphate, Disodium Salt, Pentahydrate - CAS 13408-09-8 - Calbiochem
Purity: Aphosphategroupdonorinmatrixmineralizationstudiesthatactsasaprotein
Packaging: 50g
Price: $56.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: 35675
Product name: β-Glycerophosphate, Disodium Salt, Pentahydrate - CAS 13408-09-8 - Calbiochem
Purity: Aphosphategroupdonorinmatrixmineralizationstudiesthatactsasaprotein
Packaging: 100g
Price: $85.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: 35675
Product name: β-Glycerophosphate, Disodium Salt, Pentahydrate - CAS 13408-09-8 - Calbiochem
Purity: Aphosphategroupdonorinmatrixmineralizationstudiesthatactsasaprotein
Packaging: 250g
Price: $187
Updated: 2024/03/01

TCI Chemical

Product number: D3964
Product name: Disodium beta-Glycerophosphate Pentahydrate[for Biochemical Research]
Purity: >95.0%(T)
Packaging: 1g
Price: $34
Updated: 2024/03/01

TCI Chemical

Product number: D3964
Product name: Disodium beta-Glycerophosphate Pentahydrate[for Biochemical Research]
Purity: >95.0%(T)
Packaging: 5g
Price: $71
Updated: 2024/03/01

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β-Glycerophosphate disodium salt pentahydrate Chemical Properties,Usage,Production

Description

β-Glycerophosphate is a protein phosphatase inhibitor that acts as a phosphate group donor in matrix mineralization studies. It promotes bone matrix mineralization when delivered to osteoblasts by providing a source of phosphate ions. β-Glycerophosphate (10 mM) accelerates calcification of cultured vascular smooth muscle cells through an alkaline phosphatase-related mechanism.

Chemical Properties

Solid

Uses

β-Glycerol Phosphate was shown to have promoted mineralization in vitro by modulating bone cell metabolic activity and/or serving as a local source of inorganic phosphate ions.

Uses

Sodium β-glycerophosphate pentahydrate is used as a phosphatase inhibitor. It promotes bone matrix mineralization while delivering to osteoblasts by providing a source of phosphate ions. It is used in the development of hydrogels and scaffolds, which finds applications in tissue engineering and cell growth. It is used as an additive in isolation mediums by providing phosphate ions to isolate. It is utilized to promote mineralization in vitro by modulating bone cell metabolic activity.

General Description

A phosphate group donor in matrix mineralization studies. Accelerates calcification in vascular smooth muscle cells. Also acts as a protein phosphatase inhibitor.

Biochem/physiol Actions

Beta-Glycerophosphate is a classical serine-threonine phosphatase inhibitor used in kinase reaction buffers. BGP is often used in combination with other phosphatase/protease inhibitors for broad spectrum inhibition. It functions as an organic phosphate donor and has been used in culture media for mesenchymal stem cell differentiation to osteoblast-type cells. BGP is also used to buffer M17 media for Lactococcus culture in recombinant protein expression

Purification Methods

Crystallise it from water. [Attwood et al. Biochem J 253 389 1988, Beilstein 1 IV 2766.]

References

[1]. chung ch, golub ee, forbes e, et al. mechanism of action of beta-glycerophosphate on bone cell mineralization. calcif tissue int. 1992 oct;51(4):305-11.
[2]. fujimoto h, mabuchi i. isolation of cleavage furrows from eggs of regular sea urchins and identification of furrow-specific proteins. j biochem. 1997 sep;122(3):518-24.
[3]. lecanda f, avioli lv, cheng sl. regulation of bone matrix protein expression and induction of differentiation of human osteoblasts and human bone marrow stromal cells by bone morphogenetic protein-2. j cell biochem. 1997 dec 1;67(3):386-96.
[4]. shioi a, nishizawa y, jono s, et al. beta-glycerophosphate accelerates calcification in cultured bovine vascular smooth muscle cells. arterioscler thromb vasc biol. 1995 nov;15(11):2003-9.

β-Glycerophosphate disodium salt pentahydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from β-Glycerophosphate disodium salt pentahydrate manufacturers

Career Henan Chemical Co

Product: BETA-GLYCEROL PHOSPHATE DISODIUM SALT 13408-09-8
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: ask
Release date: 2018-12-22

Career Henan Chemical Co

Product: N-(1-NAPHTHYL)-3-AMINOPROPANESULFONIC ACID SODIUM SALT 13408-09-8
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: ask
Release date: 2018-12-22

Career Henan Chemical Co

Product: PHENYL PHOSPHATE DISODIUM SALT 13408-09-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%-99%
Supply Ability: 1000kg
Release date: 2018-12-24

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