TG003

ChemicalBook > CAS DataBase List > TG003

Product Name: TG003
CAS No.: 300801-52-9
Chemical Name: TG003
Synonyms: CS-955;CS-1704;(E/Z)-TG003;TG003/TG-003;TG003 USP/EP/BP;(E/Z)-TG003, 10 mM in DMSO;Cdc2-Like Kinase Inhibitor, TG003;1-(3-Ethyl-5-methoxy-2(3H)-benzothiazolylidene)-2-propanone;2-Propanone,1-(3-ethyl-5-Methoxy-2(3H)-benzothiazolylidene)-;1-(3-Ethyl-5-methoxybenzo[d]thiazol-2(3H)-ylidene)propan-2-one
CBNumber: CB5505045
Molecular Formula: C13H15NO2S
Formula Weight: 249.33
MOL File: 300801-52-9.mol

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TG003 Property

Melting point:: 132-132.5 °C
Boiling point:: 386.0±42.0 °C(Predicted)
Density: 1.237±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 33 mg/mL
pka: -1.76±0.20(Predicted)
form: solid
color: pale yellow
Sensitive: Light Sensitive

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T5575
Product name: TG003
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $196
Updated: 2024/03/01

Sigma-Aldrich

Product number: T5575
Product name: TG003
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $778
Updated: 2024/03/01

Alfa Aesar

Product number: J64690
Product name: Cdc2-Like Kinase Inhibitor, TG003
Packaging: 5mg
Price: $85.1
Updated: 2023/06/20

Alfa Aesar

Product number: J64690
Product name: Cdc2-Like Kinase Inhibitor, TG003
Packaging: 50mg
Price: $551
Updated: 2023/06/20

Cayman Chemical

Product number: 10398
Product name: TG003
Purity: ≥95%
Packaging: 1mg
Price: $23
Updated: 2024/03/01

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TG003 Chemical Properties,Usage,Production

Description

Cdc2-like kinase (Clk), among a number of other kinases, phosphorylates serine/arginine-rich proteins which play a role in alternative splicing of pre-mRNA. The Clk family consists of four members, which include Clk1/Sty and Clk2-4. TG003 is a novel benzothiazole compound that demonstrates potent inhibition of Clk1/Sty and Clk4 with IC₅₀ values of 20 and 15 nM, respectively. TG003 exhibits considerably weaker inhibition of Clk2 and Clk3 (IC₅₀ = 200 nM and >10 μM, respectively). Through suppression of Clk-mediated phosphorylation, TG003 inhibits SF2/ASF-dependent splicing of β-globin pre-mRNA at 1 μM in vitro. At 10 μM, TG003 rescues the embryonic defects induced by excessive Clk activity in Xenopus.

Uses

TG003 has been used in PAC1 cell culture and in vitro kinase assays.

Uses

Cdc2-Like Kinase Inhibitor, TG003 is a benzothiazole agent that acts as a specific and ATP-competitive inhibitor of Clk family members. Reports show that TG003 modifies the regulation of alternative splicing modulated by phosphorylation of SR proteins in vitro, and rescues defects in the development of Xenopus caused by an overabundance of Clk activity.

Uses

TG003 can be used as a potent CDC-2 kinase inhibitor, allowing for research into identification of signaling pathways and possible therapeutic treatments.

Biochem/physiol Actions

TG003, a CLK (cdc2-like kinase) family inhibitor is used as a drug for duchenne muscular dystrophy.

TG003 Preparation Products And Raw materials

Raw materials

Preparation Products

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TG003 Suppliers

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300801-52-9, TG003Related Search:

Diethylzinc Y27632 (hydrochloride) ML167 VE-821 PD 0325901 Vorinostat PLX4032

CS-955

CS-1704

Cdc2-Like Kinase Inhibitor, TG003

TG003/TG-003

2-Propanone,1-(3-ethyl-5-Methoxy-2(3H)-benzothiazolylidene)-

(1Z)-1-(3-Ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)propan-2-one

1-(3-Ethyl-5-methoxy-2(3H)-benzothiazolylidene)-2-propanone

(Z)-1-(3-ethyl-5-methoxybenzo[d]thiazol-2(3H)-ylidene)propan-2-one

1-(3-Ethyl-5-methoxybenzo[d]thiazol-2(3H)-ylidene)propan-2-one

TG003 USP/EP/BP

(E/Z)-TG003

(E/Z) TG003,Cyclin dependent kinase,site,tumor,(E/Z)-TG003,Wilm's,(E/Z)-TG-003,splice,inhibit,mutation,Inhibitor,CDK,cancer,(E/Z)TG003,breast

(E/Z)-TG003, 10 mM in DMSO

300801-52-9

Inhibitors