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TG003

Product Name
TG003
CAS No.
300801-52-9
Chemical Name
TG003
Synonyms
CS-955;CS-1704;(E/Z)-TG003;TG003/TG-003;TG003 USP/EP/BP;Cdc2-Like Kinase Inhibitor, TG003;1-(3-Ethyl-5-methoxy-2(3H)-benzothiazolylidene)-2-propanone;2-Propanone,1-(3-ethyl-5-Methoxy-2(3H)-benzothiazolylidene)-;1-(3-Ethyl-5-methoxybenzo[d]thiazol-2(3H)-ylidene)propan-2-one;(1Z)-1-(3-Ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)propan-2-one
CBNumber
CB5505045
Molecular Formula
C13H15NO2S
Formula Weight
249.33
MOL File
300801-52-9.mol
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TG003 Property

Melting point:
132-132.5 °C
Boiling point:
386.0±42.0 °C(Predicted)
Density 
1.237±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: 33 mg/mL
pka
-1.76±0.20(Predicted)
form 
solid
color 
pale yellow
Sensitive 
Light Sensitive
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T5575
Product name
TG003
Purity
≥98% (HPLC)
Packaging
5mg
Price
$196
Updated
2024/03/01
Sigma-Aldrich
Product number
T5575
Product name
TG003
Purity
≥98% (HPLC)
Packaging
25mg
Price
$778
Updated
2024/03/01
Alfa Aesar
Product number
J64690
Product name
Cdc2-Like Kinase Inhibitor, TG003
Packaging
5mg
Price
$85.1
Updated
2023/06/20
Alfa Aesar
Product number
J64690
Product name
Cdc2-Like Kinase Inhibitor, TG003
Packaging
50mg
Price
$551
Updated
2023/06/20
Cayman Chemical
Product number
10398
Product name
TG003
Purity
≥95%
Packaging
1mg
Price
$23
Updated
2024/03/01
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TG003 Chemical Properties,Usage,Production

Description

Cdc2-like kinase (Clk), among a number of other kinases, phosphorylates serine/arginine-rich proteins which play a role in alternative splicing of pre-mRNA. The Clk family consists of four members, which include Clk1/Sty and Clk2-4. TG003 is a novel benzothiazole compound that demonstrates potent inhibition of Clk1/Sty and Clk4 with IC50 values of 20 and 15 nM, respectively. TG003 exhibits considerably weaker inhibition of Clk2 and Clk3 (IC50 = 200 nM and >10 μM, respectively). Through suppression of Clk-mediated phosphorylation, TG003 inhibits SF2/ASF-dependent splicing of β-globin pre-mRNA at 1 μM in vitro. At 10 μM, TG003 rescues the embryonic defects induced by excessive Clk activity in Xenopus.

Uses

TG003 has been used in PAC1 cell culture and in vitro kinase assays.

Uses

Cdc2-Like Kinase Inhibitor, TG003 is a benzothiazole agent that acts as a specific and ATP-competitive inhibitor of Clk family members. Reports show that TG003 modifies the regulation of alternative splicing modulated by phosphorylation of SR proteins in vitro, and rescues defects in the development of Xenopus caused by an overabundance of Clk activity.

Uses

TG003 can be used as a potent CDC-2 kinase inhibitor, allowing for research into identification of signaling pathways and possible therapeutic treatments.

Biochem/physiol Actions

TG003, a CLK (cdc2-like kinase) family inhibitor is used as a drug for duchenne muscular dystrophy.

TG003 Preparation Products And Raw materials

Raw materials

Preparation Products

300801-52-9, TG003Related Search:


  • CS-955
  • CS-1704
  • Cdc2-Like Kinase Inhibitor, TG003
  • TG003/TG-003
  • 2-Propanone,1-(3-ethyl-5-Methoxy-2(3H)-benzothiazolylidene)-
  • (1Z)-1-(3-Ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)propan-2-one
  • 1-(3-Ethyl-5-methoxy-2(3H)-benzothiazolylidene)-2-propanone
  • (Z)-1-(3-ethyl-5-methoxybenzo[d]thiazol-2(3H)-ylidene)propan-2-one
  • 1-(3-Ethyl-5-methoxybenzo[d]thiazol-2(3H)-ylidene)propan-2-one
  • TG003 USP/EP/BP
  • (E/Z)-TG003
  • (E/Z) TG003,Cyclin dependent kinase,site,tumor,(E/Z)-TG003,Wilm's,(E/Z)-TG-003,splice,inhibit,mutation,Inhibitor,CDK,cancer,(E/Z)TG003,breast
  • 300801-52-9
  • Inhibitors