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TYRPHOSTIN AG 1024

Product Name
TYRPHOSTIN AG 1024
CAS No.
65678-07-1
Chemical Name
TYRPHOSTIN AG 1024
Synonyms
CS-241;AGS 200;HY-10253;Tyrphostin;AG-1024 (Tyrphostin);AG1024; TYRPHOSTIN AG 1024;TYRPHOSTIN AG 1024 USP/EP/BP;AG-1024;TYRPHOSTIN AG1024;AGS 200;AG-1024;HY-10253; AG 1024; AGS 200;AG 1024 - CAS 65678-07-1 - Calbiochem
CBNumber
CB5505050
Molecular Formula
C14H13BrN2O
Formula Weight
305.17
MOL File
65678-07-1.mol
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TYRPHOSTIN AG 1024 Property

storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO: soluble
form 
solid
color 
yellow
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
121767
Product name
AG 1024
Packaging
1mg
Price
$113
Updated
2024/03/01
Cayman Chemical
Product number
14833
Product name
AG 1024
Purity
≥98%
Packaging
1mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
14833
Product name
AG 1024
Purity
≥98%
Packaging
5mg
Price
$85
Updated
2024/03/01
Cayman Chemical
Product number
14833
Product name
AG 1024
Purity
≥98%
Packaging
10mg
Price
$143
Updated
2024/03/01
TRC
Product number
T923510
Product name
TyrphostinAG1024
Packaging
1mg
Price
$45
Updated
2021/12/16
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TYRPHOSTIN AG 1024 Chemical Properties,Usage,Production

Description

The binding of insulin-like growth factor 1 (IGF-1) to the IGF-1 receptor (IGF-1R) initiates a cascade of reactions that promote cell growth and transformation by activating the PI3K/Akt signaling pathway, inhibiting apoptotic pathways, and mediating mitogenic actions. Overexpression of IGF-1R confers tumorigenic potential to cells as well as protection from apoptosis. AG-1024 is a selective inhibitor of IGF-1R that inhibits insulin-stimulated cellular proliferation and IGF-1R autophosphorylation with IC50 values of 0.4 and 7 μM, respectively. At 10 nM, AG-1024 can inhibit proliferation and induce apoptosis in human breast cancer MCF-7 cells, and it inhibits autocrine growth of human prostate cancer DU145 cells with an IC50 value of 2.5 μM.

Uses

Tyrphostin AG 1024 is an insulin-like growth factor (IGF)-I receptor antagonist.

Definition

ChEBI: 2-[(3-bromo-5-tert-butyl-4-hydroxyphenyl)methylidene]propanedinitrile is an alkylbenzene.

target

IGF-1R

References

[1] párrizas m1, gazit a, levitzki a, wertheimer e, leroith d. specific inhibition of insulin-like growth factor-1 and insulin receptor tyrosine kinase activity and biological function by tyrphostins. endocrinology. 1997 apr;138(4):1427-33.
[2] fan p1, agboke fa1, mcdaniel re1, sweeney ee1, zou x1, creswell k1, jordan vc2.inhibition of c-src blocks oestrogen-induced apoptosis and restores oestrogen-stimulated growth in long-term oestrogen-deprived breast cancer cells. eur j cancer. 2014 jan; 50(2):457-68.

TYRPHOSTIN AG 1024 Preparation Products And Raw materials

Raw materials

Preparation Products

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TYRPHOSTIN AG 1024 Suppliers

China 74 France 1 India 2 Switzerland 1 United Kingdom 1 United States 16 Global 95
Sequoia Research Products Ltd.
Tel
--
Fax
--
Email
sales@seqchem.com
Country
United Kingdom
ProdList
3113
Advantage
69
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View Lastest Price from TYRPHOSTIN AG 1024 manufacturers

Career Henan Chemical Co
Product
TYRPHOSTIN AG 1024 65678-07-1
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1lg; 2kg; 5kg; 10kg; 100kg
Release date
2019-08-31

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  • AG1024; TYRPHOSTIN AG 1024
  • AG 1024 - CAS 65678-07-1 - Calbiochem
  • CS-241
  • 2-[[3-Bromo-5-(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrile
  • AGS 200
  • Tyrphostin
  • 2-[[3-Bromo-5-(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrile AGS 200
  • AG-1024;HY-10253; AG 1024; AGS 200
  • HY-10253
  • AG-1024 (Tyrphostin)
  • 2-(3-broMo-5-tert-butyl-4-hydroxybenzylidene)Malononitrile
  • AG-1024;TYRPHOSTIN AG1024;AGS 200
  • Propanedinitrile, 2-[[3-bromo-5-(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-
  • TYRPHOSTIN AG 1024 USP/EP/BP
  • AG-1024 Selective IGF-1R inhibitor AG1024
  • IGF-1R,IGF1R,DNA-PKcs,phosphorylation,growth,AG1024,Apoptosis,Tyrphostin AG1024,Tyrphostin AG-1024,AG-1024,BCR-ABL,AG 1024,factor-1,Insulin Receptor,anti-cancer,Inhibitor,Akt,inhibit
  • 65678-07-1