2-Amino-5-hydroxypyrimidine
- Product Name
- 2-Amino-5-hydroxypyrimidine
- CAS No.
- 143489-45-6
- Chemical Name
- 2-Amino-5-hydroxypyrimidine
- Synonyms
- 2-Amino-5-pyrimidinol;2-Amino-pyrimidin-5-ol;5-Pyrimidinol, 2-amino-;2-Amido-5-hydroxyprimidine;2-Amino-5-hydroxypyrimidine;2-AMino-5-hydroxypyriMidi...;5-Pyrimidinol, 2-amino- (9CI);2-Amino-5-hydroxypyrimidine ISO 9001：2015 REACH;2-Aminopyrimidin-5-ol, 5-Hydroxypyrimidin-2-amine
- CBNumber
- CB5506653
- Molecular Formula
- C4H5N3O
- Formula Weight
- 111.1
- MOL File
- 143489-45-6.mol
2-Amino-5-hydroxypyrimidine Property
- Melting point:
- >170°C (dec.)
- Boiling point:
- 393.6±34.0 °C(Predicted)
- Density
- 1.450±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly, Sonicated)
- pka
- 3.95±0.23(Predicted)
- form
- Powder or Crystalline Powder
- color
- White to yellow
- CAS DataBase Reference
- 143489-45-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36-36/37/39
- HazardClass
- IRRITANT
- HS Code
- 25010019
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A611660
- Product name
- 2-Amino-5-pyrimidinol
- Packaging
- 1g
- Price
- $390
- Updated
- 2021/12/16
- Product number
- A1378-19
- Product name
- 2-Amino-5-hydroxypyrimidine
- Packaging
- 500mg
- Price
- $602
- Updated
- 2021/12/16
- Product number
- A611660
- Product name
- 2-Amino-5-pyrimidinol
- Packaging
- 10g
- Price
- $1090
- Updated
- 2021/12/16
- Product number
- 6602
- Product name
- 2-Amino-5-pyrimidinol
- Packaging
- 1.25g
- Price
- $1880
- Updated
- 2021/12/16
- Product number
- CS-W019125
- Product name
- 2-Aminopyrimidin-5-ol
- Packaging
- 1g
- Price
- $387
- Updated
- 2021/12/16
2-Amino-5-hydroxypyrimidine Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
2-Aminopyrimidin-5-ol is an endogenous metabolite.
Definition
ChEBI: 2-Amino-5-hydroxypyrimidine is a hydroxypyrimidine.
Synthesis
13418-77-4
143489-45-6
Boron tribromide (2.6 mL, 50 mmol) was slowly added dropwise to a benzene solution (60 mL) containing 5-methoxy-2-aminopyrimidine (1.25 g, 10 mmol) under argon protection. The reaction mixture was stirred under reflux conditions for 6 hours. After completion of the reaction, the mixture was allowed to stand at room temperature overnight. Subsequently, the solvent was removed by rotary evaporator and the residue was carefully treated with ice-cold deionized water (10 mL). The solution pH was adjusted to 6-7 using 6N hydrochloric acid and subsequently extracted with ethyl acetate. The organic phase was washed with saturated saline, dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated to give a yellow solid, which was purified by column chromatography (eluent ratio of 20:1 dichloromethane to methanol) to give 840 mg (75% yield) of 2-aminopyrimidin-5-ol as a white solid. The structure of the product was confirmed by 1H-NMR and electron bombardment mass spectrometry (EI-MS).1H NMR (DMSO-d6) δ 8.90 (s, 1H), 7.86 (s, 2H), 5.91 (s, 2H); EI-MS (m/z) 111 (M+).
References
[1] European Journal of Medicinal Chemistry, 1992, vol. 27, # 3, p. 207 - 217
[2] Patent: US2009/105269, 2009, A1. Location in patent: Page/Page column 10
[3] Journal of Medicinal Chemistry, 2010, vol. 53, # 3, p. 1117 - 1127
2-Amino-5-hydroxypyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Amino-5-hydroxypyrimidine manufacturers
- Product
- 2-Amino-5-hydroxypyrimidine 143489-45-6
- Price
- US $1.00-1.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50ton
- Release date
- 2020-05-19
- Product
- 2-Amino-5-hydroxypyrimidine 143489-45-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-09
- Product
- 2-Amido-5-hydroxyprimidine 143489-45-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10