ChemicalBook > CAS DataBase List > Benralizumab

Benralizumab

Product Name: Benralizumab
CAS No.: 1044511-01-4
Chemical Name: Benralizumab
Synonyms: MEDI-563;BIW-8405;Benralizumab;BIW-8405|||MEDI-563;Benralizumab (anti-IL-5Ra);Research Grade Benralizumab;Research Grade Benralizumab(DHF86301)
CBNumber: CB55821388
Formula Weight: 0
MOL File: Mol file

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Benralizumab Property

storage temp.: Store at 4°C, do not freeze
solubility: Soluble in DMSO
form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0069892
Product name: Benralizumab
Purity: ≥99.1%
Packaging: 1mg
Price: $2250
Updated: 2021/12/16

ChemScene

Product number: CS-0069892
Product name: Benralizumab
Purity: ≥99.1%
Packaging: 2mg
Price: $4100
Updated: 2021/12/16

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Benralizumab Chemical Properties,Usage,Production

Uses

Benralizumab (MEDI-563) is an interleukin-5 receptor α (IL-5Rα)-directed cytolytic monoclonal antibody that induces direct, rapid and nearly complete depletion of eosinophils via enhanced antibody-dependent cell-mediated cytotoxicity. Benralizumab can be used for severe eosinophilic asthma[1].

in vivo

Benralizumab (MEDI-563) (0-30 mg/kg; i.v.; once every 3 weeks for 12 weeks) reduces peripheral blood and bone marrow eosinophil^[2].

Animal Model:	Female and male cynomolgus monkeys^[2]
Dosage:	0.1, 1, 10, and 30 mg/kg
Administration:	Intravenous injection, once every 3 weeks for 12 weeks
Result:	Blood eosinophil counts decreased close to the limit of detection after the first administration at all dose levels and remained undetectable. Eosinophil precursors in the bone marrow were reduced 80% or greater in all doses 3 days after the last administration (terminal necropsy) and remained undetectable until 18 days after the last dose in the 30 mg/kg group. The profound effect observed in the bone marrow was specific for the eosinophil lineage.

IC 50

IL-5Rα

References

[1] Menzies-Gow A, et al. Corticosteroid tapering with benralizumab treatment for eosinophilic asthma: PONENTE Trial. ERJ Open Res. 2019 Sep 25;5(3). pii: 00009-2019. DOI:10.1183/23120541.00009-2019
[2] Kolbeck R, et al. MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function. J Allergy Clin Immunol. 2010 Jun;125(6):1344-1353.e2. DOI:10.1016/j.jaci.2010.04.004

Benralizumab Preparation Products And Raw materials

Raw materials

Preparation Products

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Benralizumab

BIW-8405

MEDI-563

Research Grade Benralizumab(DHF86301)

BIW-8405|||MEDI-563

Research Grade Benralizumab

Benralizumab (anti-IL-5Ra)

1044511-01-4