ChemicalBook > CAS DataBase List > 4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID

4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID

Product Name: 4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID
CAS No.: 34785-11-0
Chemical Name: 4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID
Synonyms: NSC 4344;AKOS BBS-00000364;IFLAB-BB F2124-0013;Sotuletinib Impurity5;4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID;3-Quinolinecarboxylic acid, 4-hydroxy-;4-hydroxyquinolinone-3-carboxylic acid;4-Hydroxyquinoline-3-carboxylic acid 97%;Ivacaftor impurities8（Kynurenic Acid Impurity 4）;4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ISO 9001：2015 REACH
CBNumber: CB5697111
Molecular Formula: C10H7NO3
Formula Weight: 189.17
MOL File: 34785-11-0.mol

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4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID Property

Melting point:: 268-273°C
Boiling point:: 384.7±32.0 °C(Predicted)
Density: 1.480
storage temp.: 2-8°C, stored under nitrogen
pka: 0.81±0.30(Predicted)
form: solid
Appearance: Off-white to light brown Solid
InChI: InChI=1S/C10H7NO3/c12-9-6-3-1-2-4-8(6)11-5-7(9)10(13)14/h1-5H,(H,11,12)(H,13,14)
InChIKey: ILNJBIQQAIIMEY-UHFFFAOYSA-N
SMILES: N1C2C(=CC=CC=2)C(O)=C(C(O)=O)C=1

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3
HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 750360
Product name: 4-Hydroxyquinoline-3-carboxylic acid
Purity: 97%
Packaging: 5g
Price: $72.5
Updated: 2025/07/31

TRC

Product number: H953448
Product name: 4-Hydroxyquinoline-3-carboxylic acid
Packaging: 250mg
Price: $55
Updated: 2021/12/16

Usbiological

Product number: 280140
Product name: 4-Hydroxyquinoline-3-carboxylic acid
Packaging: 1g
Price: $366
Updated: 2021/12/16

AK Scientific

Product number: 4232AB
Product name: 4-Hydroxyquinoline-3-carboxylic acid
Packaging: 25g
Price: $321
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-1-LJ
Product name: 4-Hydroxyquinoline-3-carboxylic acid
Packaging: 5G
Price: $360
Updated: 2021/12/16

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4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis

26892-90-0

34785-11-0

The general procedure for the synthesis of 4-hydroxyquinoline-3-carboxylic acid from ethyl 4-hydroxyquinoline-3-carboxylate was as follows: ethyl 4-hydroxyquinoline-3-carboxylate (1.2 g, 5.5 mmol) was dissolved in 20 mL of ethanol, followed by the addition of 0.1 g/mL of aqueous sodium hydroxide (6.6 mL, 16.5 mmol). The reaction was carried out under reflux conditions for 3 hours. Upon completion of the reaction, the reaction solution was cooled to 20 °C and the pH was adjusted to 4 with 4 mol/L hydrochloric acid, at which point a solid precipitated. After recovering about 10 mL of solvent ethanol by decompression distillation, the solid was collected by filtration. The solid was washed with a mixture of ethanol and water (2 mL x 2 times) and finally dried to give 0.96 g of 4-hydroxyquinoline-3-carboxylic acid in 92% yield and the product was an off-white solid.

References

[1] Molecular Crystals and Liquid Crystals Science and Technology Section A: Molecular Crystals and Liquid Crystals, 2000, vol. 344, p. 163 - 168
[2] Chemistry of Heterocyclic Compounds (New York, NY, United States), 1995, vol. 31, # 2, p. 167 - 175
[3] Khimiya Geterotsiklicheskikh Soedinenii, 1995, # 2, p. 195 - 203
[4] Patent: CN106187887, 2016, A. Location in patent: Paragraph 0015; 0048; 0049; 0050; 0051; 0052; 0053
[5] Journal of the American Chemical Society, 1946, vol. 68, p. 1264

4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID Suppliers

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View Lastest Price from 4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID manufacturers

Career Henan Chemical Co

Product: 4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID 34785-11-0
Price: US $2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: customise
Release date: 2018-08-09

34785-11-0, 4-HYDROXYQUINOLINE-3-CARBOXYLIC ACIDRelated Search:

4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID

AKOS BBS-00000364

IFLAB-BB F2124-0013

4-hydroxyquinolinone-3-carboxylic acid

3-Quinolinecarboxylic acid, 4-hydroxy-

NSC 4344

4-Hydroxyquinoline-3-carboxylic acid 97%

4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ISO 9001：2015 REACH

Ivacaftor impurities8（Kynurenic Acid Impurity 4）

Sotuletinib Impurity5

34785-11-0

Acids and Derivatives

Heterocycles