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4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID

Product Name
4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID
CAS No.
34785-11-0
Chemical Name
4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID
Synonyms
NSC 4344;AKOS BBS-00000364;IFLAB-BB F2124-0013;Sotuletinib Impurity5;4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID;3-Quinolinecarboxylic acid, 4-hydroxy-;4-hydroxyquinolinone-3-carboxylic acid;4-Hydroxyquinoline-3-carboxylic acid 97%;Ivacaftor impurities8（Kynurenic Acid Impurity 4）;4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ISO 9001：2015 REACH
CBNumber
CB5697111
Molecular Formula
C10H7NO3
Formula Weight
189.17
MOL File
34785-11-0.mol
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4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID Property

Melting point:
268-273°C
Boiling point:
384.7±32.0 °C(Predicted)
Density 
1.480
storage temp. 
2-8°C, stored under nitrogen
pka
0.81±0.30(Predicted)
form 
solid
Appearance
Off-white to light brown Solid
InChI
InChI=1S/C10H7NO3/c12-9-6-3-1-2-4-8(6)11-5-7(9)10(13)14/h1-5H,(H,11,12)(H,13,14)
InChIKey
ILNJBIQQAIIMEY-UHFFFAOYSA-N
SMILES
N1C2C(=CC=CC=2)C(O)=C(C(O)=O)C=1
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
HS Code 
2933499090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
750360
Product name
4-Hydroxyquinoline-3-carboxylic acid
Purity
97%
Packaging
5g
Price
$72.5
Updated
2025/07/31
TRC
Product number
H953448
Product name
4-Hydroxyquinoline-3-carboxylic acid
Packaging
250mg
Price
$55
Updated
2021/12/16
Usbiological
Product number
280140
Product name
4-Hydroxyquinoline-3-carboxylic acid
Packaging
1g
Price
$366
Updated
2021/12/16
AK Scientific
Product number
4232AB
Product name
4-Hydroxyquinoline-3-carboxylic acid
Packaging
1g
Price
$27
Updated
2021/12/16
SynQuest Laboratories
Product number
4H58-1-LJ
Product name
4-Hydroxyquinoline-3-carboxylic acid
Packaging
1g
Price
$160
Updated
2021/12/16
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4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis

26892-90-0

34785-11-0

The general procedure for the synthesis of 4-hydroxyquinoline-3-carboxylic acid from ethyl 4-hydroxyquinoline-3-carboxylate was as follows: ethyl 4-hydroxyquinoline-3-carboxylate (1.2 g, 5.5 mmol) was dissolved in 20 mL of ethanol, followed by the addition of 0.1 g/mL of aqueous sodium hydroxide (6.6 mL, 16.5 mmol). The reaction was carried out under reflux conditions for 3 hours. Upon completion of the reaction, the reaction solution was cooled to 20 °C and the pH was adjusted to 4 with 4 mol/L hydrochloric acid, at which point a solid precipitated. After recovering about 10 mL of solvent ethanol by decompression distillation, the solid was collected by filtration. The solid was washed with a mixture of ethanol and water (2 mL x 2 times) and finally dried to give 0.96 g of 4-hydroxyquinoline-3-carboxylic acid in 92% yield and the product was an off-white solid.

References

[1] Molecular Crystals and Liquid Crystals Science and Technology Section A: Molecular Crystals and Liquid Crystals, 2000, vol. 344, p. 163 - 168
[2] Chemistry of Heterocyclic Compounds (New York, NY, United States), 1995, vol. 31, # 2, p. 167 - 175
[3] Khimiya Geterotsiklicheskikh Soedinenii, 1995, # 2, p. 195 - 203
[4] Patent: CN106187887, 2016, A. Location in patent: Paragraph 0015; 0048; 0049; 0050; 0051; 0052; 0053
[5] Journal of the American Chemical Society, 1946, vol. 68, p. 1264

4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID Suppliers

Canada 1 China 74 Europe 2 Germany 3 India 5 United Kingdom 4 United States 13 Global 102
A.J Chemicals
Tel
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Fax
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Email
sales@ajchem.in
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India
ProdList
6100
Advantage
58
CHEMSWORTH
Tel
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Fax
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info@chemsworth.com
Country
India
ProdList
6700
Advantage
30
Dr. Jagath Reddy's Heterocyclics
Tel
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Fax
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Email
jagathreddy@usa.net
Country
India
ProdList
3886
Advantage
42
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View Lastest Price from 4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID manufacturers

Career Henan Chemical Co
Product
4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID 34785-11-0
Price
US $2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
customise
Release date
2018-08-09

34785-11-0, 4-HYDROXYQUINOLINE-3-CARBOXYLIC ACIDRelated Search:

4-Hydroxyquinoline-3-carbonitrile 4-HYDROXYQUINOLINE-3-CARBOXALDEHYDE 4-HYDROXY-8-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLIC ACID 6-CHLORO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID 6-FLUORO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 4-HYDROXY-7-METHOXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLIC ACID ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE XANTHURENIC ACID ETHYL 4-HYDROXY-2-QUINOLINECARBOXYLATE METHYL 6-BROMO-4-HYDROXYQUINOLINE-2-CARBOXYLATE 7-BROMO-4-HYDROXYQUINOLINE 4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER, 95+%,4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 6-FLUORO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID 6-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID 8-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID 3-HYDROXYQUINOLINE-2-CARBOXYLIC ACID 4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID

  • 4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID
  • AKOS BBS-00000364
  • IFLAB-BB F2124-0013
  • 4-hydroxyquinolinone-3-carboxylic acid
  • 3-Quinolinecarboxylic acid, 4-hydroxy-
  • NSC 4344
  • 4-Hydroxyquinoline-3-carboxylic acid 97%
  • 4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ISO 9001：2015 REACH
  • Ivacaftor impurities8（Kynurenic Acid Impurity 4）
  • Sotuletinib Impurity5
  • 34785-11-0
  • Acids and Derivatives
  • Heterocycles