ChemicalBook > CAS DataBase List > 2-Pyrimidinemethanol

2-Pyrimidinemethanol

Product Name
2-Pyrimidinemethanol
CAS No.
42839-09-8
Chemical Name
2-Pyrimidinemethanol
Synonyms
2-PYRIMIDINEMETHANOL;PyriMidin-2-ylMetharol;PYRIMIDIN-2-YLMETHANOL;2-(HYDROXYMETHYL)-PYRIMIDINE;2-(Hydroxymethyl)pyrimidi...;2-Pyrimidinemethanol (7CI,9CI);2-Pyrimidinemethanol ISO 9001：2015 REACH;(PYRIMIDIN-2-YL)METHANOL,PURITY:95% MIN(HPLC)
CBNumber
CB5702431
Molecular Formula
C5H6N2O
Formula Weight
110.11
MOL File
42839-09-8.mol
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2-Pyrimidinemethanol Property

Boiling point:
198.2±23.0 °C(Predicted)
Density 
1.227±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 100 mg/ml; PBS (pH 7.2): 10 mg/ml
form 
A crystalline solid
pka
13.61±0.10(Predicted)
color 
Colorless to light yellow
CAS DataBase Reference
42839-09-8(CAS DataBase Reference)
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Safety

RIDADR 
1993
HazardClass 
3
PackingGroup 
Ⅲ
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10007112
Product name
2-(Hydroxymethyl)-Pyrimidine
Purity
≥95%
Packaging
50mg
Price
$36
Updated
2024/03/01
Cayman Chemical
Product number
10007112
Product name
2-(Hydroxymethyl)-Pyrimidine
Purity
≥95%
Packaging
100mg
Price
$50
Updated
2024/03/01
Cayman Chemical
Product number
10007112
Product name
2-(Hydroxymethyl)-Pyrimidine
Purity
≥95%
Packaging
500mg
Price
$179
Updated
2024/03/01
Cayman Chemical
Product number
10007112
Product name
2-(Hydroxymethyl)-Pyrimidine
Purity
≥95%
Packaging
1g
Price
$250
Updated
2024/03/01
Usbiological
Product number
286545
Product name
2-Pyrimidinemethanol
Packaging
250mg
Price
$360
Updated
2021/12/16
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2-Pyrimidinemethanol Chemical Properties,Usage,Production

Uses

2-?Pyrimidinemethanol is a reactant used in the synthesis of avanafil, which is used to treat erectile dysfunction. Also used in the synthesis of

Synthesis

34253-03-7

42839-09-8

Synthesis of pyrimidin-2-ylmethanol (12): ester 11 (0.43 g, 3.09 mmol) was dissolved in EtOH (30 mL), stirred and cooled to 0 °C. NaBH4 (0.114 g, 3.09 mmol) was slowly added under stirring and the reaction mixture continued to stir for 2 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming complete consumption of the raw materials, the reaction was quenched with cold water. Subsequently, the reaction mixture was concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography with MeOH/CH2Cl2 (1:49) as eluent to afford alcohol 12 (0.145 g, 37% yield). The product had an Rf value of 0.3 in 10% MeOH/CHCl3.1H NMR (500 MHz, CDCl3) δ: 8.75 (d, J = 5.5 Hz, 2H), 7.26-7.22 (m, 1H), 4.85 (s, 2H). Mass spectrum (ESI): m/z 111.1 [M+H]+.

References

[1] Patent: WO2013/13238, 2013, A2. Location in patent: Page/Page column 33
[2] Patent: US2010/63066, 2010, A1. Location in patent: Page/Page column 15
[3] Patent: US2007/49603, 2007, A1. Location in patent: Page/Page column 53; 78
[4] Patent: WO2012/40230, 2012, A1. Location in patent: Page/Page column 80-81
[5] Patent: WO2013/142269, 2013, A1. Location in patent: Paragraph 0507; 0508

2-Pyrimidinemethanol Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Pyrimidinemethanol Suppliers

China 146 Czech Republic 1 Europe 1 Germany 2 India 3 United Kingdom 5 United States 19 Global 177
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View Lastest Price from 2-Pyrimidinemethanol manufacturers

Dideu Industries Group Limited
Product
2-Pyrimidinemethanol 42839-09-8
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-12-06
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-Pyrimidinemethanol 42839-09-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-Pyrimidinemethanol 42839-09-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

42839-09-8, 2-PyrimidinemethanolRelated Search:

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  • PyriMidin-2-ylMetharol
  • (PYRIMIDIN-2-YL)METHANOL,PURITY:95% MIN(HPLC)
  • 2-Pyrimidinemethanol ISO 9001：2015 REACH
  • 42839-09-8
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