2-Pyrimidinemethanol
- Product Name
- 2-Pyrimidinemethanol
- CAS No.
- 42839-09-8
- Chemical Name
- 2-Pyrimidinemethanol
- Synonyms
- 2-PYRIMIDINEMETHANOL;PyriMidin-2-ylMetharol;PYRIMIDIN-2-YLMETHANOL;2-(HYDROXYMETHYL)-PYRIMIDINE;2-(Hydroxymethyl)pyrimidi...;2-Pyrimidinemethanol (7CI,9CI);2-Pyrimidinemethanol ISO 9001：2015 REACH;(PYRIMIDIN-2-YL)METHANOL,PURITY:95% MIN(HPLC)
- CBNumber
- CB5702431
- Molecular Formula
- C5H6N2O
- Formula Weight
- 110.11
- MOL File
- 42839-09-8.mol
2-Pyrimidinemethanol Property
- Boiling point:
- 198.2±23.0 °C(Predicted)
- Density
- 1.227±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 100 mg/ml; PBS (pH 7.2): 10 mg/ml
- form
- A crystalline solid
- pka
- 13.61±0.10(Predicted)
- color
- Colorless to light yellow
- CAS DataBase Reference
- 42839-09-8(CAS DataBase Reference)
Safety
- RIDADR
- 1993
- HazardClass
- 3
- PackingGroup
- Ⅲ
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 10007112
- Product name
- 2-(Hydroxymethyl)-Pyrimidine
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 10007112
- Product name
- 2-(Hydroxymethyl)-Pyrimidine
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $50
- Updated
- 2024/03/01
- Product number
- 10007112
- Product name
- 2-(Hydroxymethyl)-Pyrimidine
- Purity
- ≥95%
- Packaging
- 500mg
- Price
- $179
- Updated
- 2024/03/01
- Product number
- 10007112
- Product name
- 2-(Hydroxymethyl)-Pyrimidine
- Purity
- ≥95%
- Packaging
- 1g
- Price
- $250
- Updated
- 2024/03/01
- Product number
- 286545
- Product name
- 2-Pyrimidinemethanol
- Packaging
- 250mg
- Price
- $360
- Updated
- 2021/12/16
2-Pyrimidinemethanol Chemical Properties,Usage,Production
Uses
2-?Pyrimidinemethanol is a reactant used in the synthesis of avanafil, which is used to treat erectile dysfunction. Also used in the synthesis of
Synthesis
34253-03-7
42839-09-8
Synthesis of pyrimidin-2-ylmethanol (12): ester 11 (0.43 g, 3.09 mmol) was dissolved in EtOH (30 mL), stirred and cooled to 0 °C. NaBH4 (0.114 g, 3.09 mmol) was slowly added under stirring and the reaction mixture continued to stir for 2 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming complete consumption of the raw materials, the reaction was quenched with cold water. Subsequently, the reaction mixture was concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography with MeOH/CH2Cl2 (1:49) as eluent to afford alcohol 12 (0.145 g, 37% yield). The product had an Rf value of 0.3 in 10% MeOH/CHCl3.1H NMR (500 MHz, CDCl3) δ: 8.75 (d, J = 5.5 Hz, 2H), 7.26-7.22 (m, 1H), 4.85 (s, 2H). Mass spectrum (ESI): m/z 111.1 [M+H]+.
References
[1] Patent: WO2013/13238, 2013, A2. Location in patent: Page/Page column 33
[2] Patent: US2010/63066, 2010, A1. Location in patent: Page/Page column 15
[3] Patent: US2007/49603, 2007, A1. Location in patent: Page/Page column 53; 78
[4] Patent: WO2012/40230, 2012, A1. Location in patent: Page/Page column 80-81
[5] Patent: WO2013/142269, 2013, A1. Location in patent: Paragraph 0507; 0508
2-Pyrimidinemethanol Preparation Products And Raw materials
Raw materials
Preparation Products
2-Pyrimidinemethanol Suppliers
- Tel
- --
- Fax
- --
- info@chemsworth.com
- Country
- India
- ProdList
- 6700
- Advantage
- 30
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from 2-Pyrimidinemethanol manufacturers
- Product
- 2-Pyrimidinemethanol 42839-09-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-06
- Product
- 2-Pyrimidinemethanol 42839-09-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 2-Pyrimidinemethanol 42839-09-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08