Travoprost
- Product Name
- Travoprost
- CAS No.
- 157283-68-6
- Chemical Name
- Travoprost
- Synonyms
- Trovoprost;Trivo;FLU-IPR;AL 6221;Travatan;ravopros;Trivoprost;Travaprost;TRAVOPROST;Travoprostt
- CBNumber
- CB5703458
- Molecular Formula
- C26H35F3O6
- Formula Weight
- 500.55
- MOL File
- 157283-68-6.mol
Travoprost Property
- alpha
- D20 +14.6° (c = 1.0 in methylene chloride)
- Boiling point:
- 584.8±50.0 °C(Predicted)
- Density
- 1.245±0.06 g/cm3(Predicted)
- Flash point:
- 17 °C
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Dichloromethane (Sparingly, Sonicated), Chloroform (Sparingy), Methanol (Sparing
- form
- ethanol solution
- pka
- 13.43±0.20(Predicted)
- color
- Colourless to Light Beige
- BCS Class
- 2
- Stability:
- Light Sensitive
- InChIKey
- MKPLKVHSHYCHOC-AHTXBMBWSA-N
- CAS DataBase Reference
- 157283-68-6(CAS DataBase Reference)
Safety
- Hazard Codes
- F,Xi
- Risk Statements
- 11-36/37/38
- Safety Statements
- 16-26-36-7
- RIDADR
- UN 1170 3/PG 2
- WGK Germany
- 1
- HS Code
- 2937500000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- PHR1622
- Product name
- Travoprost
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 3mL
- Price
- $173
- Updated
- 2024/03/01
- Product number
- 1673001
- Product name
- Travoprost
- Packaging
- 3ml
- Price
- $436
- Updated
- 2024/03/01
- Product number
- 16769
- Product name
- Fluprostenol isopropyl ester
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $70
- Updated
- 2024/03/01
- Product number
- 16769
- Product name
- Fluprostenol isopropyl ester
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $308
- Updated
- 2024/03/01
- Product number
- 16769
- Product name
- Fluprostenol isopropyl ester
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $545
- Updated
- 2024/03/01
Travoprost Chemical Properties,Usage,Production
Description
Travoprost was launched in the US as Travatan?, an ophthalmic solution (0.004%) administered topically for the treatment of elevated intraocular hypertension (lOP) through open-angle glaucoma, a common optic neuropathy and a leading cause of blindness. Travoprost is the isopropyl ester of (+)-fluprostenol, a new prostaglandin derivative belonging to the PGF2α, analog class. This compound can be prepared in 8 steps from a bicyclic lactone aldehyde by a Wittig alkylidenation followed, after 2 ketonic reductions, by a lactol opening to prostenoic acid while protecting and deprotecting appropriately. Travoprost is a full agonist of FP receptors with a greater affinity than PGF2α, (K1 = 52 nM). Pharmacologic studies in rabbits treated daily for a week demonstrated a significant increase of the microvascular optic nerve head blood flow without significant alterations in the systemic flow. In several placebo-controlled clinical studies with hundreds of patients suffering from open-angle glaucoma or ocular hypertension, travoprost (1 to 4 pm daily) dose-dependently reduced lOP (by about 30% at 4 pm); it was shown equal or superior to latanoprost, another prostaglandin analog (5 pm daily) or the adrenergic ~-blocker timolol (500 pm bid). In addition, travoprost was safe and well tolerated with a low incidence of conjunctival hyperaemia.
Chemical Properties
Colorless Oil
Originator
Alcon (US)
Uses
Travoprost is a selective FP prostaglandin receptor agonist used to treat glaucoma (1,2).
Uses
treatment conditions arising from excess uric acid, eg chronic gout
Uses
Selective FP prostaglandin receptor agonist. Isopropyl ester of (+)-fluprostenol. Antiglaucoma
Definition
ChEBI: The isopropyl ester of prostaglandin F2alpha in which the pentyl group is replaced by a 3-(trifluoromethyl)phenoxymethyl group. A synthetic analogue of prostaglandin F2alpha, ophth lmic solutions of travoprost are used as a topical medication for controlling the progression of open-angle glaucoma and ocular hypertension, by reducing intraocular pressure. It is a pro-drug; the isopropyl ester group is hydrolysed by esterases in the co nea to the biologically active free acid, fluprostenol.
brand name
Travatan
General Description
Travoprost (Travatan and Travatan-Z) is supplied asa 2.5- or 5.0-mL sterile 0.004% ophthalmic solution in a4.0- or 7.5-mL size container. Travoprost is claimed to bethe most potent and FP-specific analog in this product category. Cautions and side effects are similar to those givenpreviously.
Travoprost Preparation Products And Raw materials
Raw materials
Preparation Products
Travoprost Suppliers
- Tel
- 0576-84613060 13093829633
- Fax
- 0576-84613060
- sales@kedechemical.com
- Country
- China
- ProdList
- 298
- Advantage
- 60
- Tel
- 21-13482015261-883 13482015261
- Fax
- +86-21-37782903
- info@genriverpharm.com
- Country
- China
- ProdList
- 444
- Advantage
- 58
- Tel
- 021-021-00000000 18221039705
- Fax
- QQ:17263424
- finetechpharm@126.com
- Country
- China
- ProdList
- 208
- Advantage
- 58
- Tel
- 27-027-83314682 13554138826
- Fax
- +86 (27) 8331-4682
- whsrtech@vip.163.com
- Country
- China
- ProdList
- 229
- Advantage
- 62
- Tel
- +86-0576-88813233 +86-13396860566
- sales@pharm-intermediates.com
- Country
- China
- ProdList
- 1991
- Advantage
- 58
- Tel
- Fax
- 86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2922
- Advantage
- 55
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-50790412
- Fax
- +86-21-50790419
- info@chemvon.com
- Country
- China
- ProdList
- 371
- Advantage
- 57
- Tel
- +86-21-20908456
- Fax
- 021-58180499
- sales@BioChemBest.com
- Country
- China
- ProdList
- 6005
- Advantage
- 61
- Tel
- 1-(800)-881-8210
- Fax
- 615-250-9817
- inquiries@lgmpharma.com
- Country
- United States
- ProdList
- 2123
- Advantage
- 70
View Lastest Price from Travoprost manufacturers
- Product
- Travoprost 157283-68-6
- Price
- US $0.00/Kg/Bag
- Min. Order
- 2Kg/Bag
- Purity
- USP32
- Supply Ability
- 20 tons
- Release date
- 2021-07-13
- Product
- Travoprost 157283-68-6
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 96%-102%
- Supply Ability
- 100G
- Release date
- 2021-07-07
- Product
- Travaprost 157283-68-6
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 20tons
- Release date
- 2024-04-11