Neferine

Product Name: Neferine
CAS No.: 2292-16-2
Chemical Name: Neferine
Synonyms: Neferin;NEFERINE;Methylliensinine;Neferine USP/EP/BP;4''-O-Methylliensinine;Neferine, 10 mM in DMSO;4-[[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-[[(1R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenol;4-[(1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methylisoquinolin-1-yl)methyl]-2-[[1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methylisoquinolin-7-yl]oxy]phenol;4-(((S)-6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-2-(((R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)oxy)phenol;4-[[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-[[(1R)-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenol
CBNumber: CB5706015
Molecular Formula: C38H44N2O6
Formula Weight: 624.77
MOL File: 2292-16-2.mol

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Neferine Property

Melting point:: 59-61 °C
Boiling point:: 710.9±60.0 °C(Predicted)
Density: 1.185±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: >15mg/mL
form: powder
pka: 9.28±0.45(Predicted)
color: white to beige
optical activity: [α]/D -34 to -44° (c=0 3. CHCl3)
InChIKey: MIBATSHDJRIUJK-ROJLCIKYSA-N

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Safety

WGK Germany: 3
RTECS: SM9495000

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0349
Product name: Neferine
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $113
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0349
Product name: Neferine
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $441
Updated: 2024/03/01

Usbiological

Product number: 300672
Product name: Neferine
Packaging: 20mg
Price: $490
Updated: 2021/12/16

TRC

Product number: N389200
Product name: Neferine
Packaging: 5mg
Price: $220
Updated: 2021/12/16

ChemScene

Product number: CS-5848
Product name: Neferine
Purity: 99.92%
Packaging: 25mg
Price: $170
Updated: 2021/12/16

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Neferine Chemical Properties,Usage,Production

Description

A bisbenzylisoquinoline alkaloid from Nelumbo nucifera, the structure of this base has been shown to be that represented above based upon chemical degrada_x0002_tive studies and spectroscopic data. Four methoxyl groups, one hydroxyl and two methylimino groups are present.

Uses

Neferine is an isoquinoline alkaloid which enhances the antitumor effect of Mitomycin-C in hela cells through activation of p38-MAPK. Useful in the treatment of cervical cancers.

Definition

ChEBI: Neferine is a member of isoquinolines.

Biochem/physiol Actions

Neferine is a bis-benzylisoquinoline alkaloid isolated from the green seed embryos Nelumbo Nucifera Gaertn (Lotus) that displays multiple pharmacological activities including anti-tumor, antidepressant-like and antiarrhythmic actions. Recent studies shown that neferine potently inhibits proliferation of human osteosarcoma cells while is low-toxic on non-neoplastic human osteoblast cells. Apparently in U2OS cells, neferine stabilizes p21 through the activation of p38 MAPK, which leads to G1 cell cycle arrest. Also, neferine inhibits Ang II-induced HUVSMC proliferation by upregulation of HO-1.

References

Yang, Chen.,J. Chin. Chem. Soc., 17,235 (1970)

Neferine Preparation Products And Raw materials

Raw materials

Preparation Products

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Neferine Suppliers

China 182 Germany 1 India 1 United Kingdom 1 United States 18 USA 1 Global 204

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View Lastest Price from Neferine manufacturers

Shaanxi Haibo Biotechnology Co., Ltd

Product: Neferine 2292-16-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-08-24

Shanghai Standard Technology Co., Ltd.

Product: Neferine 2292-16-2
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-10-28

Career Henan Chemical Co

Product: Neferine 2292-16-2
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg,5kg,50kg
Release date: 2020-01-18

2292-16-2, NeferineRelated Search:

Vincristine 13,14-Didehydromatridin-15-one Hydroxytyrosol Vincristine sulfate Aloe emodin Kresoxim-methyl Liensinine Thiophanate-methyl Bensulfuron methyl Methyl acetate Methylparaben METSULFURON METHYL Methyl acrylate Methyl Parathion-methyl Methyl bromide Isoliensinine Neferine

Phenol,4-[[(1S)-1,2,3,4-tetrahydro-6,7-diMethoxy-2-Methyl-1-isoquinolinyl]Methyl]-2-[[(1R)-1,2,3,4-tetrahydro-6-Methoxy-1-[(4-Methoxyphenyl)Methyl]-2-Methyl-7-isoquinolinyl]oxy]-

4-[[(1S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]-2-[[(1R)-1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-7-isoquinolinyl]oxy]-phenol

4-[(1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methylisoquinolin-1-yl)methyl]-2-[[1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methylisoquinolin-7-yl]oxy]phenol

4-[[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-[[(1R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenol

Neferin

NEFERINE

4''-O-Methylliensinine

Methylliensinine

4-[[(1r)-6,7-dimethoxy-2-methyl-3,4-dihydro-1h-isoquinolin-1-yl]methyl]-2-[[(1r)-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-3,4-dihydro-1h-isoquinolin-7-yl]oxy]phenol

Neferine USP/EP/BP

4-[[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-[[(1R)-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenol

4-(((S)-6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-2-(((R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)oxy)phenol

Neferine, 10 mM in DMSO

2292-16-2

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

chemical reagent

pharmaceutical intermediate

phytochemical