tert-Butyl diethylphosphonoacetate

Product Name: tert-Butyl diethylphosphonoacetate
CAS No.: 27784-76-5
Chemical Name: tert-Butyl diethylphosphonoacetate
Synonyms: tert-butyl 2-(diethoxyphosphoryl)acetate;tert-Butyl diethylph;DIETHYL (BOC-METHYL)PHOSPHONATE;T-BUTYL DIETHYL PHOSPHONOACETATE;Tert-buty diethylphosphonoacetate;tert-Butyl diethylphosponoacetate;Tert-butyl diethylphosphonoactate;TERT-BUTYL DIETHYLPHOSPHONOACETATE;Tert-butyl diehylphosphonoacetate;Tert-butyl diethyl phosphonylacetate
CBNumber: CB5708211
Molecular Formula: C10H21O5P
Formula Weight: 252.24
MOL File: 27784-76-5.mol

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tert-Butyl diethylphosphonoacetate Property

Boiling point:: 100-103 °C/1.5 mmHg (lit.)
Density: 1.074 g/mL at 25 °C (lit.)
refractive index: n20/D 1.431(lit.)
Flash point:: >230 °F
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
form: Liquid
Specific Gravity: 1.074
color: Clear colorless
Water Solubility: Not miscible or difficult to mix in water.
BRN: 2050126
InChI: InChI=1S/C10H21O5P/c1-6-13-16(12,14-7-2)8-9(11)15-10(3,4)5/h6-8H2,1-5H3
InChIKey: NFEGNISFSSLEGU-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)CP(OCC)(OCC)=O
CAS DataBase Reference: 27784-76-5(CAS DataBase Reference)

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Safety

Risk Statements: 36/38
Safety Statements: 26-36-24/25
WGK Germany: 3
HS Code: 29319090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 348333
Product name: tert-Butyl diethylphosphonoacetate
Purity: 95%
Packaging: 5g
Price: $114
Updated: 2023/01/07

TCI Chemical

Product number: B2814
Product name: tert-Butyl Diethylphosphonoacetate
Purity: >97.0%(GC)
Packaging: 1g
Price: $28
Updated: 2024/03/01

TCI Chemical

Product number: B2814
Product name: tert-Butyl Diethylphosphonoacetate
Purity: >97.0%(GC)
Packaging: 5g
Price: $80
Updated: 2024/03/01

Alfa Aesar

Product number: L17651
Product name: tert-Butyl diethylphosphonoacetate, 95%
Packaging: 5g
Price: $90.65
Updated: 2024/03/01

Alfa Aesar

Product number: L17651
Product name: tert-Butyl diethylphosphonoacetate, 95%
Packaging: 1g
Price: $29.7
Updated: 2021/12/16

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tert-Butyl diethylphosphonoacetate Chemical Properties,Usage,Production

Chemical Properties

Clear colorless liquid

Uses

tert-Butyl diethylphosphonoacetate is used as a reactant for preparation of hydroxymethylated dihydroxyvitamin D3 analogs via Wittig-Horner approach, as potential antitumor agents, synthesis of phosphopeptide mimetic prodrugs targeted to Src homology 2 (SH2) domain of signal transducer and activator of transcription 3 (Stat 3) and bicyclic triaminophosphine-promoted stereoselective synthesis of a,?-unsaturated esters, fluorides, and nitriles from aldehydes and ketones using Wadsworth-Emmons phosphonates

reaction suitability

reaction type: C-C Bond Formation

Synthesis

Triethyl phosphite (485 g) is warmed up to 90°C under N2 atmosphere in a three-necked round-bottomed flask, and /-butyl bromoacetate (541 g) is added dropwise into the system within 2 h. Then, the mixture is stirred at 90°C for around 4 hours and cooled to room temperature. The obtained mixture is distilled under vacuo to remove compounds with low boiling points, and the residue is collected as a colorless liquid tert-butyl diethylphosphonoacetate in 97 percent yield (680 g).

tert-Butyl diethylphosphonoacetate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from tert-Butyl diethylphosphonoacetate manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: tert-Butyl diethylphosphonoacetate 27784-76-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-30

Shaanxi Dideu Medichem Co. Ltd

Product: tert-Butyl diethylphosphonoacetate 27784-76-5
Price: US $1.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 Tons
Release date: 2020-01-14

Hangzhou ICH Biofarm Co., Ltd

Product: tert-Butyl diethylphosphonoacetate 27784-76-5
Price: US $0.00-0.00/kg
Min. Order: 0.10000000149011612kg
Purity: 99.0%min
Supply Ability: 200kg
Release date: 2023-07-03

27784-76-5, tert-Butyl diethylphosphonoacetateRelated Search:

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DIETHYL(2-TERT-BUTOXYCARBONYLMETHYL)PHOSPHONATE

(DIETHOXYPHOSPHORYL)ACETIC ACID TERT-BUTYL ESTER

DIETHYL (BOC-METHYL)PHOSPHONATE

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ACETIC ACID, 2-(DIETHOXYPHOSPHINYL)-, 1,1-DIMETHYLETHYL ESTER

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Diethyl(2-tert-butoxycarbonylmethyl)phosphonate 98%

tert-Butyl diethylph

tert-butyl 2-(diethoxyphosphoryl)acetate

(Diethoxyphosphinyl)acetic acid 1,1-dimethylethyl ester

Diethyl tert-butoxycarbonylmethanephosphonate

tert-Butyl (diethoxyphosphinyl)acetate

<i>tert</i>-Butyl diethylphosphonoacetate

Diethyl (Boc-methyl)phosphonate Diethyl (tert-Butoxycarbonylmethyl)phosphonate Diethylphosphonoacetic Acid tert-Butyl Ester

tert-Butyl diethylphosponoacetate

Tert-butyl diethylphosphonoactate

tert-Butyl Diethylphosphonoacetate &gt

Tert-butyl diethyl phosphonylacetate

TERT-BUTYL DIETHYLPHOSPHONOACETATE (27784-76-5)

1,1-Dimethylethyl 2-(diethoxyphosphinyl)acetate

ert-butyl2-diethoxyphosphorylacetate

Diethyl phosphonoyl acetate tert butyl ester

27784-76-5

C2H5O2POCH2CO2CCH33

Horner-Wadsworth-Emmons Reagents

Olefination

Synthetic Reagents

C-C Bond Formation

Horner-Wadsworth-Emmons Reagents

Olefination

27784-76-5