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Phentolamine mesilate

Product Name
Phentolamine mesilate
CAS No.
65-28-1
Chemical Name
Phentolamine mesilate
Synonyms
PHENTOLAMINE MESYLATE;REGITIN;VASOMAX;PhentoL;FE202158;FE 202158;amine MesyL;Phentolamine me;REGITIN MESYLATE;regitinemesylate
CBNumber
CB5708736
Molecular Formula
C18H23N3O4S
Formula Weight
377.46
MOL File
65-28-1.mol
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Phentolamine mesilate Property

Melting point:
180-182 °C(lit.)
Density 
1.2256 (rough estimate)
refractive index 
1.6320 (estimate)
storage temp. 
2-8°C
solubility 
ethanol: 26 mg/mL
form 
powder
color 
white to off-white
Water Solubility 
50 mg/mL
Merck 
14,7264
Stability:
Aq. Solutions Cannot be Stored
InChI
InChI=1S/C17H19N3O.CH4O3S/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;1-5(2,3)4/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H3,(H,2,3,4)
InChIKey
OGIYDFVHFQEFKQ-UHFFFAOYSA-N
SMILES
N(CC1=NCCN1)(C1C=CC(C)=CC=1)C1C=CC=C(O)C=1.S(=O)(=O)(O)C
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36
RIDADR 
3249
WGK Germany 
3
RTECS 
SL5430000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29332900
Toxicity
LDLo scu-rat: 275 mg/kg NIIRDN 6,667,82
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0001251
Product name
Phentolamine mesilate for system suitability
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
10 mg
Price
$228
Updated
2025/07/31
Sigma-Aldrich
Product number
Y0001127
Product name
Phentolamine mesilate
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
10 mg
Price
$153
Updated
2025/07/31
Sigma-Aldrich
Product number
P7561
Product name
Phentolamine methanesulfonate salt
Purity
≥98% (TLC), powder
Packaging
100mg
Price
$98.6
Updated
2025/07/31
Sigma-Aldrich
Product number
BP520
Product name
Phentolamine mesilate
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$262
Updated
2025/07/31
Sigma-Aldrich
Product number
1530004
Product name
Phentolamine mesylate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$393
Updated
2025/07/31
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Phentolamine mesilate Chemical Properties,Usage,Production

Chemical Properties

Phentolamine mesylate is a white, odourless powder which is soluble in water and alcohol.

Uses

Phentolamine mesilate is an adrenergic blocking agent and antihypertensive. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of raynaud disease and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.

brand name

Regitine (Novartis) [Name previously used: Phentolamine Methanesulfonate.].

General Description

Phentolamine Mesylate belongs to the class of alpha adrenergic antagonist drugs. It is used in the treatment of pheochromocytoma-related hypertension, erectile dysfunction and in the diagnosis of pheochromocytoma and norepinephrine-related dermal necrosis.

Biochem/physiol Actions

α-Adrenergic receptor antagonist; peripheral vasodilator.

Clinical Use

Alpha-adrenoceptor blocker:
Hypertensive crisis

Safety Profile

Poison by intravenous and subcutaneous routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx and NOx.

Drug interactions

Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Antidepressants: additive hypotensive effect with MAOIs - avoid.
Antihypertensives: enhanced hypotensive effect.
Avanafil, vardenafil, sildenafil and tadalafil: enhanced hypotensive effect - avoid concomitant use.
Diuretics: enhanced hypotensive effect.
Linezolid: additive hypotensive effect.
Moxisylyte: possibly severe postural hypotension.

Metabolism

Phentolamine is extensively metabolised.
Only about 10-13% of an intravenous dose is excreted unchanged in the urine, and the fate of the remainder of the drug is unknown.

storage

Store at +4°C

Mode of action

Phentolamine Mesylate is the mesylate salt of a synthetic imidazoline with alpha-adrenergic antagonist activity. As a competitive alpha-adrenergic antagonist, phentolamine binds to alpha-1 and alpha-2 receptors, resulting in a decrease in peripheral vascular resistance and vasodilatation. This agent also may block 5-hydroxytryptamine (5-HT) receptors and stimulate release of histamine from mast cells.

Phentolamine mesilate Preparation Products And Raw materials

Raw materials

Methanesulfonic acid Chloroacetonitrile

Preparation Products

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Phentolamine mesilate Suppliers

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View Lastest Price from Phentolamine mesilate manufacturers

Shaanxi Didu New Materials Co. Ltd
Product
Phentolamine mesilate 65-28-1
Price
US $1.50/g
Min. Order
1g
Purity
99.0% Min
Supply Ability
10 Tons
Release date
2025-06-25
Shaanxi Xianhe Biotech Co., Ltd
Product
Phentolamine mesilate 65-28-1
Price
US $0.00/KG
Min. Order
1KG
Purity
0.99
Supply Ability
1000KG
Release date
2025-05-06
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Phentolamine mesilate 65-28-1
Price
US $0.00/Kg/Bag
Min. Order
1KG
Purity
98%-102%; USP
Supply Ability
1000KGS
Release date
2021-08-10

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