Phentolamine mesilate

Product Name: Phentolamine mesilate
CAS No.: 65-28-1
Chemical Name: Phentolamine mesilate
Synonyms: PHENTOLAMINE MESYLATE;REGITIN;VASOMAX;PhentoL;FE202158;FE 202158;amine MesyL;Phentolamine me;REGITIN MESYLATE;regitinemesylate
CBNumber: CB5708736
Molecular Formula: C18H23N3O4S
Formula Weight: 377.46
MOL File: 65-28-1.mol

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Phentolamine mesilate Property

Melting point:: 180-182 °C(lit.)
Density: 1.2256 (rough estimate)
refractive index: 1.6320 (estimate)
storage temp.: 2-8°C
solubility: ethanol: 26 mg/mL
form: powder
color: white to off-white
Water Solubility: 50 mg/mL
Merck: 14,7264
Stability:: Aq. Solutions Cannot be Stored
InChI: InChI=1S/C17H19N3O.CH4O3S/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;1-5(2,3)4/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H3,(H,2,3,4)
InChIKey: OGIYDFVHFQEFKQ-UHFFFAOYSA-N
SMILES: N(CC1=NCCN1)(C1C=CC(C)=CC=1)C1C=CC=C(O)C=1.S(=O)(=O)(O)C

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 20/21/22-36/37/38
Safety Statements: 26-36
RIDADR: 3249
WGK Germany: 3
RTECS: SL5430000
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 29332900
Toxicity: LDLo scu-rat: 275 mg/kg NIIRDN 6,667,82

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P7561
Product name: Phentolamine methanesulfonate salt
Purity: ≥98% (TLC), powder
Packaging: 100mg
Price: $45.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1530004
Product name: Phentolamine mesylate
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $436
Updated: 2024/03/01

Sigma-Aldrich

Product number: BP520
Product name: Phentolamine mesilate
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 100MG
Price: $253
Updated: 2023/06/20

TCI Chemical

Product number: P1985
Product name: Phentolamine Mesylate
Purity: >98.0%(HPLC)(T)
Packaging: 100mg
Price: $57
Updated: 2024/03/01

TCI Chemical

Product number: P1985
Product name: Phentolamine Mesylate
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $278
Updated: 2024/03/01

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Phentolamine mesilate Chemical Properties,Usage,Production

Chemical Properties

Phentolamine mesylate is a white, odourless powder which is soluble in water and alcohol.

Uses

Phentolamine mesilate is an adrenergic blocking agent and antihypertensive. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of raynaud disease and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.

brand name

Regitine (Novartis) [Name previously used: Phentolamine Methanesulfonate.].

General Description

Phentolamine Mesylate belongs to the class of alpha adrenergic antagonist drugs. It is used in the treatment of pheochromocytoma-related hypertension, erectile dysfunction and in the diagnosis of pheochromocytoma and norepinephrine-related dermal necrosis.

Biochem/physiol Actions

α-Adrenergic receptor antagonist; peripheral vasodilator.

Clinical Use

Alpha-adrenoceptor blocker:
Hypertensive crisis

Safety Profile

Poison by intravenous and subcutaneous routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx and NOx.

Drug interactions

Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Antidepressants: additive hypotensive effect with MAOIs - avoid.
Antihypertensives: enhanced hypotensive effect.
Avanafil, vardenafil, sildenafil and tadalafil: enhanced hypotensive effect - avoid concomitant use.
Diuretics: enhanced hypotensive effect.
Linezolid: additive hypotensive effect.
Moxisylyte: possibly severe postural hypotension.

Metabolism

Phentolamine is extensively metabolised.
Only about 10-13% of an intravenous dose is excreted unchanged in the urine, and the fate of the remainder of the drug is unknown.

storage

Store at +4°C

Mode of action

Phentolamine Mesylate is the mesylate salt of a synthetic imidazoline with alpha-adrenergic antagonist activity. As a competitive alpha-adrenergic antagonist, phentolamine binds to alpha-1 and alpha-2 receptors, resulting in a decrease in peripheral vascular resistance and vasodilatation. This agent also may block 5-hydroxytryptamine (5-HT) receptors and stimulate release of histamine from mast cells.

Phentolamine mesilate Preparation Products And Raw materials

Raw materials

Methanesulfonic acid Chloroacetonitrile

Preparation Products

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Phentolamine mesilate Suppliers

Belgium 1 Brazil 1 Canada 2 China 304 Egypt 1 Europe 2 Germany 6 India 14 Italy 2 Japan 1 Mexico 1 Poland 1 Switzerland 1 United Kingdom 11 United States 49 Global 397

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Taizhou Creating Bio-pharm Co.,Ltd.

Tel: +86-0576-88827176 +86-18906581668
Email: post@creatingchemical.com
Country: China
ProdList: 229
Advantage: 58

Hubei Kailong Biotechnology Co.,Ltd.

Tel: 19526384105
Email: 3671394075@qq.com
Country: China
ProdList: 2864
Advantage: 58

Jiangxi ravel Biotechnology Co.,Ltd

Tel: 400-880-2824 18107960669
Fax: 18140514863
Email: 79046690@qq.com
Country: China
ProdList: 1267
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 021-61259108 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44688
Advantage: 61

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

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View Lastest Price from Phentolamine mesilate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Phentolamine mesilate 65-28-1
Price: US $0.00/Kg/Bag
Min. Order: 1KG
Purity: 98%-102%; USP
Supply Ability: 1000KGS
Release date: 2021-08-10

Baoji Guokang Bio-Technology Co., Ltd.

Product: Phentolamine mesilate 65-28-1
Price: US $645.00/KG
Min. Order: 500g
Purity: 99%
Supply Ability: 1000KG
Release date: 2021-06-04

Wuhan Senwayer Century Chemical Co.,Ltd

Product: Phentolamine mesilate 65-28-1
Price: US $1300.00/kg
Min. Order: 1kg
Purity: 99% min
Supply Ability: 20 tons
Release date: 2022-10-14

65-28-1, Phentolamine mesilateRelated Search:

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REGITIN

REGITIN MESYLATE

PHENTOLAMINE MESILATE

PHENTOLAMINE MESYLATE

PHENTOLAMINE METHANESULFONATE

PHENTOLAMINE METHANESULFONATE SALT

VASOMAX

m-(n-(2-imidazolin-2-ylmethyl)-p-toluidino)-phenomonomethanesulfonate(sal

amine MesyL

PhentoL

phentolaminemethanesulphonate

3-[4,5-Dihydro-1H-imidazol-2-ylmethyl-(4-methylphenyl)-amino]phenol methanesulfonate

Phentolamine·methanesulfonic acid

Regitine methanesulfonate

Phentolamine mesilat

Phentolamine Mesylate (200 mg)

2-[N-(m-Hydroxyphenyl)-p-toluidinomethyl]imidazoline Methanesulfonate Phentolamine Methanesulfonate

3-[[(4,5-dihydro-1H-imidazol-2-yl)methyl](4-methylphenyl)amino]-phenol, methanesulfonate (1:1)

Phentolamine mesilate for system suitability

Phentolamine mesylate, >=99%

Phentolamine mesilate(Regitine)

regitinemesylate

Phentolamine mesylate, ≥98.0%(TLC)

regitinmethanesulphonate

2-[N-(M-HYDROXYPHENYL)-P-TOLUIDINOMETHYL]IMIDAZOLINE, METHANESULFONATE

2-(N-[M-HYDROXYPHENYL]-P-TOLUIDINOMETHYL)IMIDAZOLINE METHANESULFONATE SALT

2-[N-(M-HYDROXYPHENYL)-P-TOLUIDINOMETHYL]IMIDAZOLIN METHANESULFONATE SALT

3-[[(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)METHYL](4-METHYLPHENYL)-AMINO]PHENOL MESYLATE

3-[n-(2-imidazolin-2-ylmethyl)-p-toluidino]phenol methanesulphonate

PHENOL, 3-(((4,5-DIHYDRO-1H-IMIDAZOL-2-YL)METHYL)(4-METHYLPHENYL)AMINO)-, MONOMETHANESULFONATE (SALT)

PhentolamineMesylateCp2000/Usp26Gmp

Phentolaminemethanesulfonate,99%

PHENTOLAMINEMESYLATE,USP

PHENTOLAMINE METHANESULFONATE (PHENTOLAMINE MESYLATE)

Phentolamine methanesulfonate salt, 98%, a nonselective alpha-adrenergic antagonist

Phentolamine mesilate CRS

PhentolamineMesylate&gt

Phentolamine for system suitability CRS

Phentolaminmesilat

Phentolamine mesilate USP/EP/BP

Phentolamine Mesylate (1530004)

FE 202158

FE202158

3-(((4,5-Dihydro-1H-imidazol-2-yl)methyl)(p-tolyl)amino)phenol methanesulfonate

(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid (benzylpenicillin)

Phentolamine me

65-28-1

C17H19N3OCH4O3SC18H23

C17H19N3OCH3SO3H

C17H19N3OCH4O3SC18H23N3O4S

C17H19N3O.CH4O3S

Analytical Standards

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