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Levocetirizine

Product Name
Levocetirizine
CAS No.
130018-77-8
Chemical Name
Levocetirizine
Synonyms
LEVOCETRIZINE;(R)-2-[2-[4-(4-chlorophenyl)-phenylmethyl]-phenylmethyl-1-]-piperazinyl-]ethoxyl﹞acetic acid dihydrochloride;alerlisin;Cetirizine-d4;LEVOCETIRIZINE;(R)-Cetirizine;Levocetirizine-d4;(R)-Cetirizine-d4;Cetirizine R-Isomer;Levocetirizine-IP/IHS
CBNumber
CB5712207
Molecular Formula
C21H25ClN2O3
Formula Weight
388.89
MOL File
130018-77-8.mol
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Levocetirizine Property

Melting point:
205-208°C (dec.)
Boiling point:
542.1±45.0 °C(Predicted)
Density 
1.237±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO: 78 mg/mL (200.57 mM);Ethanol: 78 mg/mL (200.57 mM)
pka
3.46±0.10(Predicted)
form 
Solid
color 
White to off-white
Water Solubility 
Water: 78 mg/mL (200.57 mM)
BCS Class
3
CAS DataBase Reference
130018-77-8(CAS DataBase Reference)
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Safety

HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
L379253
Product name
Levocetirizine
Packaging
50mg
Price
$125
Updated
2021/12/16
TRC
Product number
L379253
Product name
Levocetirizine
Packaging
500mg
Price
$795
Updated
2021/12/16
TRC
Product number
L379253
Product name
Levocetirizine
Packaging
1g
Price
$1400
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0003160
Product name
LEVOCETIRIZINE HYDROCHLORIDE
Purity
95.00%
Packaging
1G
Price
$644.46
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0003160
Product name
LEVOCETIRIZINE HYDROCHLORIDE
Purity
95.00%
Packaging
5G
Price
$867.48
Updated
2021/12/16
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Levocetirizine Chemical Properties,Usage,Production

Description

The (R)-enantiomer of the second-generation antihistamine cetirizine, levocetirizine, was first introduced in Germany for seasonal allergic rhinitis (including ocular symptoms), perennial allergic rhinitis and chronic idiopathic urticaria. The dihydrochloride salt can be prepared in four steps from optically active 4-chlorobenzhydrylamine obtained by resolution of its racemate with (+)-tartaric acid. Levocetirizine (eutomer) is a 2-fold more potent H1 antagonist than cetirizine whereas the other enantiomer (distomer) is 10-fold less potent compared to levocetirizine. Pharmacodynamic studies on healthy volunteers showed that compared to cetirizine, half the dose of levocetirizine (5 mg) was necessary to obtain similar inhibitory effects in the skin test of histamine-induced wheal and flare as well as on histamine-induced nasal congestion and nasal resistance. There was no evidence of chiral inversion of levocetirizine in vivo in several species including human. The daily dose of drug is rapidly and extensively absorbed in human. Interestingly, its volume of distribution (0.41 kg/L) is smaller than that of the distomer (0.60 kg/L). The low volume of distribution is considered as favorable for an antihistamine both in terms of efficacy and safety. Due to its high metabolic stability and lack of effect on the activities of the major CYP isoenzymes, levocetirizine is unlikely to cause interactions with other administered drugs. No clinically relevant effect on electrocardiograms of healthy volunteers was detected.

Chemical Properties

Off-White Solid

Originator

Sepracor (US)

Uses

A nonsedating type histamine H1-receptor antagonist. A major metabolite of Hydroxyzine. Pharmacological activity resides primarily in the (R)-isomer. Antihystaminic.

Uses

H1 antihistamine, antiallergic

Uses

Labeled cetirizine, intended for use as an internal standard for the quantification of cetirizine by GC- or LC-mass spectrometry.

Definition

ChEBI: 2-[2-[4-[(R)-(4-chlorophenyl)-phenylmethyl]-1-piperazinyl]ethoxy]acetic acid is a diarylmethane.

brand name

Xusal

Clinical Use

Antihistamine:
Symptomatic relief of allergy such as hay fever, urticaria

Levocetirizine Preparation Products And Raw materials

Raw materials

Preparation Products

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Levocetirizine Suppliers

Canada 3 China 110 Europe 2 Germany 2 India 25 United Kingdom 3 United States 25 Global 170
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View Lastest Price from Levocetirizine manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Levocetirizine 130018-77-8
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-11-13
Hebei Mingeng Biotechnology Co., Ltd
Product
Levocetirizine 130018-77-8
Price
US $200.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg/Month
Release date
2022-11-27
Shijiazhuang Gantuo Biotechnology Co., Ltd
Product
Levocetirizine 130018-77-8
Price
US $100.00/mg
Min. Order
10mg
Purity
99%
Supply Ability
10000g
Release date
2023-03-10

130018-77-8, LevocetirizineRelated Search:

1-BENZHYDRYLPIPERAZINE Ethyl 2-(Chlorosulfonyl)acetate 2-Methylphenylacetic acid 1-Methylpiperazine Ethoxymethylenemalononitrile Cetirizine Methanol Methyl acrylate PHENYL VALERATE Dichloromethylphenylsilane Triphenyltin acetate Dimethylbenzylcarbinyl acetate Tribenuron methyl 1,2-Dimethylhydrazine Dihydrochloride Methyl 2,2-dimethylphenylacetate Levamisole (S)-Amlodipine Methyl

  • LEVOCETIRIZINE
  • alerlisin
  • 2-[2-[4-[(R)-(4-chlorophenyl)-phenylmethyl]-1-piperazinyl]ethoxy]acetic acid
  • Cetirizine Impurity 20
  • (R)-2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetic acid
  • LEVOCETRIZINE
  • (R)-2-[2-[4-(4-chlorophenyl)-phenylmethyl]-phenylmethyl-1-]-piperazinyl-]ethoxyl﹞acetic acid dihydrochloride
  • LevocetirizineHydrochloride
  • 2-[2-[4-[(4-Chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid
  • Cetirizine-d4
  • Levocetirizine-d4
  • (R)-Cetirizine
  • (R)-Cetirizine Dihydrochloride
  • 2-[2-[4-[(R)-(4-Chlorophenyl)phenylMethyl]-1-piperazinyl]ethoxy]acetic Acid Dihydrochloride
  • (R)-Cetirizine-d4
  • -2-(2-(4-((4-Chlorophenyl)
  • Cetirizine R-Isomer
  • Acetic acid, 2-[2-[4-[(R)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-
  • Levoce/0/2/7/5/9/8/4/7/2/5/5/-tirizine
  • Levocetirizine-IP/IHS
  • LevocetirizineQ: What is Levocetirizine Q: What is the CAS Number of Levocetirizine Q: What is the storage condition of Levocetirizine
  • Benodanil Impurity 17 (Pyracarbolid)
  • Levocetirizine Hydrochloride IP / USP
  • Levocetirizine (R)-2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1- yl)ethoxy)acetic acid
  • LevocetirizineDihydrochloride(USP)
  • 130018-77-8
  • C21H21ClN2O3D4
  • C21H25ClN2O3
  • XYZAL
  • Aromatics
  • Chiral Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals