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2-Methylpropanedioic acid

Product Name
2-Methylpropanedioic acid
CAS No.
516-05-2
Chemical Name
2-Methylpropanedioic acid
Synonyms
METHYLMALONIC ACID;2-Methylmalonic acid;AI315327;onic acid;NSC 25201;AI3 15327;AI3-15327;Methylmalonic;isosuccinicacid;Isosuccinic acid
CBNumber
CB5713714
Molecular Formula
C4H6O4
Formula Weight
118.09
MOL File
516-05-2.mol
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2-Methylpropanedioic acid Property

Melting point:
128-130 °C (lit.)
Boiling point:
272.71°C (rough estimate)
Density 
1.45
refractive index 
1.4304 (estimate)
Flash point:
2℃
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Crystalline Powder
pka
3.07, 5.76(at 25℃)
color 
White
Specific Gravity
1.455
PH
3.23(1 mM solution);2.6(10 mM solution);2.05(100 mM solution)
Water Solubility 
soluble
BRN 
1756084
CAS DataBase Reference
516-05-2(CAS DataBase Reference)
NIST Chemistry Reference
Methylmalonic acid(516-05-2)
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Safety

Hazard Codes 
Xi,Xn,F
Risk Statements 
36/37/38-36-20/21/22-11
Safety Statements 
26-36/37-16
RIDADR 
UN 1648 3 / PGII
WGK Germany 
3
RTECS 
OO1400000
HS Code 
29171900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M54058
Product name
Methylmalonic acid
Purity
99%
Packaging
5g
Price
$65.8
Updated
2024/03/01
Sigma-Aldrich
Product number
M-080
Product name
Methylmalonic acid solution
Purity
1.0?mg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1mL
Price
$113
Updated
2024/03/01
TCI Chemical
Product number
M0568
Product name
Methylmalonic Acid
Purity
>98.0%(T)
Packaging
25g
Price
$74
Updated
2024/03/01
Cayman Chemical
Product number
14885
Product name
Methylmalonate
Purity
≥95%
Packaging
1g
Price
$20
Updated
2024/03/01
Cayman Chemical
Product number
14885
Product name
Methylmalonate
Purity
≥95%
Packaging
5g
Price
$48
Updated
2024/03/01
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2-Methylpropanedioic acid Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder

Uses

Methylmalonic acid can be used as a substrate in:

  • Esterification reactions by various catalysts.
  • Synthesis of pyrimidinium betaines with formamidine.
  • Synthesis of malonic acid half thioester (MAHT).

Uses

2-Methylpropanedioic acid binds with coenzyme A to form methylmalonyl-CoA, also a metabolic intermediate transformed to succinic acid (SA) by a vitamin B12-dependent catalytic step, and is broadly used as a clinical biomarker of functional vitamin B12 status.

Definition

ChEBI: Methylmalonic acid is a dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group. It has a role as a human metabolite. It is functionally related to a malonic acid. It is a conjugate acid of a methylmalonate(1-).

Biological Functions

Methylmalonic acid is capable of diffusing out of cells in which it is being produced, so it may be detected in excess in the blood, CSF, and urine of patients with these various forms of the disease.

General Description

Methylmalonic acid is an indicator of vitamin B12 deficiency and methylmalonic acidemia. This Certified Spiking Solution? is suitable for use in preparation of calibrators or controls in clinical and diagnostic testing using GC/MS or LC/MS.

storage

Store at RT

Purification Methods

The acid crystallises as the hydrate from water. [Beilstein 2 IV 1932.]

2-Methylpropanedioic acid Preparation Products And Raw materials

Raw materials

Preparation Products

cyclamen aldehyde
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2-Methylpropanedioic acid Suppliers

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View Lastest Price from 2-Methylpropanedioic acid manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
2-Methylpropanedioic acid 516-05-2
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 mt
Release date
2024-11-15
Xiamen Yunfan Biotech Co.,Ltd.
Product
2-Methylpropanedioic acid 516-05-2
Price
US $0.00-0.00/KG
Min. Order
5KG
Purity
99%
Supply Ability
1000 kg/Month
Release date
2024-05-15
Hebei Mojin Biotechnology Co., Ltd
Product
2-Methylpropanedioic acid 516-05-2
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-24

516-05-2, 2-Methylpropanedioic acidRelated Search:

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  • 1,1-Ethanedicarboxylic acid
  • 1,1-ethanedicarboxylicacid
  • 2-Methylmalonic acid
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  • Isosuccinic acid
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  • METHYLMALONIC ACID
  • METHYLPROPANEDIOIC ACID
  • 2-METHYLPROPANEDIOIC ACID
  • PROPANEDIOIC ACID, METHYL-
  • MethylmalonicAcid&gt
  • Propanedioic acid, 2-methyl-
  • Flurbiprofen Impurity 28
  • 516-05-2 2-Methylpropanedioic acid C4H6O4
  • AI3 15327
  • AI315327
  • AI3-15327
  • NSC 25201|||MMA|||Isosuccinic acid|||Methylpropanedioic acid|||Methylmalonate
  • Methylmalonic acid in methanol
  • Methylmalonic Acid in Acetonitrile
  • Methyl Malonic Acid / 2-Methylpropanedioc acid
  • 516-05-2
  • HOOCCHCH3COOH
  • CH3CHCO2H2
  • Carboxylic Acids
  • Carbonyl Compounds
  • C1 to C5
  • Building Blocks
  • Organic Building Blocks
  • Building Blocks
  • C1 to C5
  • Carbonyl Compounds
  • Carboxylic Acids
  • Chemical Synthesis
  • Organic Building Blocks
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
  • API intermediates
  • Aliphatics
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
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