5-Methylnicotinic acid
- Product Name
- 5-Methylnicotinic acid
- CAS No.
- 3222-49-9
- Chemical Name
- 5-Methylnicotinic acid
- Synonyms
- RARECHEM AL BO 2392;Methomyl Impurity 3;5-Methylnicotic acid;5-METHYLNICOTINIC ACID;5-Methylnicohinic acid;5-Methylnicotinicacid,97%;Nicotinic Acid Impurity 28;5-Methylnicotinic acid 98%;Nicotine Related Compound 4;5-Methylnicotinic acid, 95+%
- CBNumber
- CB5714690
- Molecular Formula
- C7H7NO2
- Formula Weight
- 137.14
- MOL File
- 3222-49-9.mol
5-Methylnicotinic acid Property
- Melting point:
- 210-212°C
- Boiling point:
- 303.9±22.0 °C(Predicted)
- Density
- 1.230±0.06 g/cm3(Predicted)
- vapor pressure
- 0.328Pa at 25℃
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Sparingly soluble (0.083 g/L at 25°C).
- pka
- 2.27±0.10(Predicted)
- form
- Solid:particulate/powder
- Appearance
- White to off-white Solid
- BRN
- 112288
- InChI
- InChI=1S/C7H7NO2/c1-5-2-6(7(9)10)4-8-3-5/h2-4H,1H3,(H,9,10)
- InChIKey
- DJDHHXDFKSLEQY-UHFFFAOYSA-N
- SMILES
- C1=NC=C(C)C=C1C(O)=O
- LogP
- 1.23
- CAS DataBase Reference
- 3222-49-9(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 681237
- Product name
- 5-Methylpyridine-3-carboxylic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $77.5
- Updated
- 2023/06/20
- Product number
- M218850
- Product name
- 5-MethylnicotinicAcid
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 281572
- Product name
- 5-Methylnicotinic acid
- Packaging
- 10g
- Price
- $322
- Updated
- 2021/12/16
- Product number
- CHM0034626
- Product name
- 5-METHYL NICOTINIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $613.88
- Updated
- 2021/12/16
- Product number
- CHM0034626
- Product name
- 5-METHYL NICOTINIC ACID
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $867.17
- Updated
- 2021/12/16
5-Methylnicotinic acid Chemical Properties,Usage,Production
Chemical Properties
Solid
Uses
5-Methylnicotinic acid is an important raw material and intermediate used in organic synthesis, pharmaceuticals and agrochemicals.
Synthesis
5-Methylnicotinic acid can be prepared by a one-step reaction under the condition of aqueous solvent, using 3,5-dimethylpyridine as the starting material and potassium permanganate as the oxidising agent, and reacted under mild conditions. The specific preparation method is as follows:
A, to 1200L running water is added in 2000L enamel reaction stills, then squeeze into 3,5- lutidines 120kg, stir, Between 25-35°C of temperature control, and 300kg potassium permanganate is added with 4.5h, be then incubated 30°C of reaction 16h；
B, filter core filter by-product manganese dioxide, and filtrate adjusts pH0.5 with concentrated hydrochloric acid；
C, centrifugation filter by-product 3, and 5- pyridinedicarboxylic acids, filtrate continuation adjusts PH3.0, crude product is collected by centrifugation with concentrated hydrochloric acid；
D, drying, crude product 1200L ethanol are heated to 80°C of dissolvings, heat filtering, and filtrate is cooled to 0-5°C of stirring 2h, from The heart, in drying 8.5h at 65°C, you can.The purity of final product is 99.5%.
References
[1] Patent: US2009/54395, 2009, A1. Location in patent: Page/Page column 42
[2] Patent: EP1193265, 2002, A2. Location in patent: Page 72
[3] Journal of Medicinal Chemistry, 1994, vol. 37, # 17, p. 2697 - 2703
[4] Journal of Chemical Research, Miniprint, 1987, # 9, p. 2360 - 2384
5-Methylnicotinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Methylnicotinic acid manufacturers
- Product
- 5-Methylnicotinic acid 3222-49-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-02-06
- Product
- 5-Methylnicotinic acid 3222-49-9
- Price
- US $10.00-8.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-12-06
- Product
- 5-Methylnicotinic acid 3222-49-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-19