ChemicalBook > CAS DataBase List > 5-Methylnicotinic acid

5-Methylnicotinic acid

Product Name: 5-Methylnicotinic acid
CAS No.: 3222-49-9
Chemical Name: 5-Methylnicotinic acid
Synonyms: RARECHEM AL BO 2392;Methomyl Impurity 3;5-Methylnicotic acid;5-METHYLNICOTINIC ACID;5-Methylnicohinic acid;5-Methylnicotinicacid,97%;Nicotinic Acid Impurity 28;5-Methylnicotinic acid 98%;Nicotine Related Compound 4;5-Methylnicotinic acid, 95+%
CBNumber: CB5714690
Molecular Formula: C7H7NO2
Formula Weight: 137.14
MOL File: 3222-49-9.mol

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5-Methylnicotinic acid Property

Melting point:: 210-212°C
Boiling point:: 303.9±22.0 °C(Predicted)
Density: 1.230±0.06 g/cm3(Predicted)
vapor pressure: 0.328Pa at 25℃
storage temp.: Inert atmosphere,Room Temperature
solubility: Sparingly soluble (0.083 g/L at 25°C).
pka: 2.27±0.10(Predicted)
form: Solid:particulate/powder
Appearance: White to off-white Solid
BRN: 112288
InChI: InChI=1S/C7H7NO2/c1-5-2-6(7(9)10)4-8-3-5/h2-4H,1H3,(H,9,10)
InChIKey: DJDHHXDFKSLEQY-UHFFFAOYSA-N
SMILES: C1=NC=C(C)C=C1C(O)=O
LogP: 1.23
CAS DataBase Reference: 3222-49-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 681237
Product name: 5-Methylpyridine-3-carboxylic acid
Purity: 97%
Packaging: 1g
Price: $77.5
Updated: 2023/06/20

TRC

Product number: M218850
Product name: 5-MethylnicotinicAcid
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Usbiological

Product number: 281572
Product name: 5-Methylnicotinic acid
Packaging: 10g
Price: $322
Updated: 2021/12/16

Oakwood

Product number: 024697
Product name: 5-Methylnicotinicacid
Purity: 97%
Packaging: 1g
Price: $9
Updated: 2021/12/16

Oakwood

Product number: 024697
Product name: 5-Methylnicotinicacid
Purity: 97%
Packaging: 5g
Price: $10
Updated: 2021/12/16

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5-Methylnicotinic acid Chemical Properties,Usage,Production

Chemical Properties

Solid

Uses

5-Methylnicotinic acid is an important raw material and intermediate used in organic synthesis, pharmaceuticals and agrochemicals.

Synthesis

5-Methylnicotinic acid can be prepared by a one-step reaction under the condition of aqueous solvent, using 3,5-dimethylpyridine as the starting material and potassium permanganate as the oxidising agent, and reacted under mild conditions. The specific preparation method is as follows:
A, to 1200L running water is added in 2000L enamel reaction stills, then squeeze into 3,5- lutidines 120kg, stir, Between 25-35°C of temperature control, and 300kg potassium permanganate is added with 4.5h, be then incubated 30°C of reaction 16h；
B, filter core filter by-product manganese dioxide, and filtrate adjusts pH0.5 with concentrated hydrochloric acid；
C, centrifugation filter by-product 3, and 5- pyridinedicarboxylic acids, filtrate continuation adjusts PH3.0, crude product is collected by centrifugation with concentrated hydrochloric acid；
D, drying, crude product 1200L ethanol are heated to 80°C of dissolvings, heat filtering, and filtrate is cooled to 0-5°C of stirring 2h, from The heart, in drying 8.5h at 65°C, you can.The purity of final product is 99.5%.

References

[1] Patent: US2009/54395, 2009, A1. Location in patent: Page/Page column 42
[2] Patent: EP1193265, 2002, A2. Location in patent: Page 72
[3] Journal of Medicinal Chemistry, 1994, vol. 37, # 17, p. 2697 - 2703
[4] Journal of Chemical Research, Miniprint, 1987, # 9, p. 2360 - 2384

5-Methylnicotinic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-Methylnicotinic acid manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 5-Methylnicotinic acid 3222-49-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-06

Hebei Chuanghai Biotechnology Co., Ltd

Product: 5-Methylnicotinic acid 3222-49-9
Price: US $10.00-8.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-12-06

Henan Aochuang Chemical Co.,Ltd.

Product: 5-Methylnicotinic acid 3222-49-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-19

3222-49-9, 5-Methylnicotinic acidRelated Search:

EPA Folic acid Xanthinol nicotinate Isonicotinic acid Citric acid Ascoric Acid Diethyl pyridine-3,5-dicarboxylate DIETHYL 2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLATE 5-ETHYLPYRIDINE-2,3-DICARBOXYLIC ACID Imazameth DIMETHYL 4-(4-METHOXYPHENYL)-2,6-DIMETHYLPYRIDINE-3,5-DICARBOXYLATE 3,5-PYRIDINEDICARBOXYLIC ACID 2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID CARBOXYLIC ACID 5-Methylnicotinic acid METHYL 2-ETHYL-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXYLATE ETHYL 5-CYANO-6-(METHYLSULFANYL)-2-PHENYLNICOTINATE ETHYL 2-[2-(3,5-DICHLOROANILINO)VINYL]-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXYLATE

5-METHYLNICOTINIC ACID

5-METHYPYRIDINE-3-CARBOXYLIC ACID

5-METHYLPYRIDINE-3-CARBOXYLIC ACID

RARECHEM AL BO 2392

5-Methylnicotinicacid,97%

5-METHYL-3-PYRIDINECARBOXYLICACID

5-Methylnicotinic acid, tech

5-Methylnicotic acid

5-Methylnicotinic acid, 95+%

5-Methylpyridine-3-carboxylic acid 97%

5-methylpyridine-3-carboxylic acid(5-methylnicotinic acid)

5-Methylnicotinic acid≥ 98% (HPLC)

5-Methylnicotinic Acid(WX614246)

Nicotine Related Compound 4

3-Pyridinecarboxylic acid, 5-methyl-

5-Methylnicohinic acid

5-Methylnicotinic acid ISO 9001：2015 REACH

Nicotinic Acid Impurity 28

Methomyl Impurity 3

5-Methylnicotinic acid 98%

5-methylpyridine-3-carboxylicaci

3222-49-9

3222-49-4

C7H7O2N

Building Blocks

Pyridine

Pyridines

pharmacetical

Nitrogen cyclic compounds

Pyridine Series

bc0001

3222-49-9