2-Chloro-6-methoxypyridine
- Product Name
- 2-Chloro-6-methoxypyridine
- CAS No.
- 17228-64-7
- Chemical Name
- 2-Chloro-6-methoxypyridine
- Synonyms
- Chloro-6-Methoxypyrid;oro-6-methoxypyridine;2-Chlor-6-methoxypyridine;2-CHLORO-6-METHOXYPYRIDINE;6-Chloro-2-methoxypyridine;2-Methoxy-6-chloropyridine;6-Methoxy-2-chloropyridine;Pyridine, 2-chloro-6-methoxy-;2-Chloro-6-methoxypyridine 98%;2-Chloro-6-methoxypyridine,98%
- CBNumber
- CB5729582
- Molecular Formula
- C6H6ClNO
- Formula Weight
- 143.57
- MOL File
- 17228-64-7.mol
2-Chloro-6-methoxypyridine Property
- Boiling point:
- 185-186 °C (lit.)
- Density
- 1.207 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.528(lit.)
- Flash point:
- 169 °F
- storage temp.
- Inert atmosphere,Room Temperature
- form
- clear liquid
- pka
- 0.40±0.10(Predicted)
- color
- Colorless to Almost colorless
- BRN
- 1364500
- InChI
- InChI=1S/C6H6ClNO/c1-9-6-4-2-3-5(7)8-6/h2-4H,1H3
- InChIKey
- VAVGOGHLNAJECD-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC(OC)=CC=C1
- CAS DataBase Reference
- 17228-64-7(CAS DataBase Reference)
- NIST Chemistry Reference
- Pyridine, 2-chloro-6-methoxy-(17228-64-7)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39-37/39
- RIDADR
- 2810
- WGK Germany
- 3
- Hazard Note
- Irritant
- PackingGroup
- III
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 152730
- Product name
- 2-Chloro-6-methoxypyridine
- Purity
- 98%
- Packaging
- 25g
- Price
- $114
- Updated
- 2025/07/31
- Product number
- 152730
- Product name
- 2-Chloro-6-methoxypyridine
- Purity
- 98%
- Packaging
- 5g
- Price
- $27
- Updated
- 2023/06/20
- Product number
- C0197
- Product name
- 2-Chloro-6-methoxypyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $16
- Updated
- 2025/07/31
- Product number
- C0197
- Product name
- 2-Chloro-6-methoxypyridine
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $43
- Updated
- 2025/07/31
- Product number
- C368740
- Product name
- 2-Chloro-6-methoxy-pyridine
- Packaging
- 5g
- Price
- $50
- Updated
- 2021/12/16
2-Chloro-6-methoxypyridine Chemical Properties,Usage,Production
Chemical Properties
Clear colorless to light yellow liquid
Uses
2-Chloro-6-methoxy-pyridine is a reagent used to synthesize imidazo[1,2-a]pyrimidines as functionally selective GABAA ligands. It can also be used to synthesize oxazolidinedione-arylpyridinones as EP3 receptor antagonists.
General Description
The FT-Raman and Fourier transform infrared (FTIR) spectra of 2-Chloro-6-methoxypyridine has been studied.
Synthesis
2402-78-0
67-56-1
17228-64-7
To a stirred solution of 2,6-dichloropyridine (68.9 g, 466 mmol) in methanol (500 mL) was slowly added sodium methanolate (100 g, 1.86 mol) at room temperature. The reaction mixture was stirred continuously at 60°C for 24 hours. After completion of the reaction, the mixture was cooled to room temperature, the reaction was quenched with 2 M aqueous hydrochloric acid and extracted with dichloromethane (CH2Cl2). The organic layers were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to afford 2-chloro-6-methoxypyridine (66.9 g, quantitative yield) as a colorless oil. The product characterization data were as follows: IR (thin film method, cm?1 ): 1599, 1585, 1560, 1468, 1410, 1302, 1265, 1152, 1024, 876, 789; 1H-NMR (CDCl3, 500 MHz) δ: 7.51 (t, J = 7.37 Hz, 1H), 6.90 (d, J = 7.37 Hz, 1H), 6.65 (d, J = 7.37 Hz, 1H), 3.94 (s, 3H); 13C-NMR (CDCl3, 125 MHz) δ: 163.9, 148.4, 140.5, 116.2, 109.1, 54.0; HR-MS (ESI-TOF): the calculated C6H7ClNO [(M + H)+] value was 144.0211 and the measured value was 144.0211.
References
[1] Chemical and Pharmaceutical Bulletin, 2016, vol. 64, # 7, p. 723 - 732
[2] Patent: CN107935922, 2018, A. Location in patent: Paragraph 0036-0038; 0039-0040; 0045-0048; 0059-0061
[3] Patent: CN106905229, 2017, A. Location in patent: Paragraph 0022; 0023
[4] Chemical & Pharmaceutical Bulletin, 1986, vol. 34, # 9, p. 3658 - 3671
[5] Patent: CN107954928, 2018, A. Location in patent: Paragraph 0017; 0018; 0019; 0020; 0021
2-Chloro-6-methoxypyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Chloro-6-methoxypyridine Suppliers
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View Lastest Price from 2-Chloro-6-methoxypyridine manufacturers
- Product
- 2-Chloro-6-methoxypyridine 17228-64-7
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2025-03-13
- Product
- 2-Chloro-6-methoxypyridine 17228-64-7
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2021-10-14
- Product
- 2-Chloro-6-methoxypyridine 17228-64-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-22