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2-Chloro-6-methoxypyridine

Product Name
2-Chloro-6-methoxypyridine
CAS No.
17228-64-7
Chemical Name
2-Chloro-6-methoxypyridine
Synonyms
Chloro-6-Methoxypyrid;oro-6-methoxypyridine;2-Chlor-6-methoxypyridine;2-CHLORO-6-METHOXYPYRIDINE;6-Chloro-2-methoxypyridine;2-Methoxy-6-chloropyridine;6-Methoxy-2-chloropyridine;Pyridine, 2-chloro-6-methoxy-;2-Chloro-6-methoxypyridine 98%;2-Chloro-6-methoxypyridine,98%
CBNumber
CB5729582
Molecular Formula
C6H6ClNO
Formula Weight
143.57
MOL File
17228-64-7.mol
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2-Chloro-6-methoxypyridine Property

Boiling point:
185-186 °C (lit.)
Density 
1.207 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.528(lit.)
Flash point:
169 °F
storage temp. 
Inert atmosphere,Room Temperature
form 
clear liquid
pka
0.40±0.10(Predicted)
color 
Colorless to Almost colorless
BRN 
1364500
InChI
InChI=1S/C6H6ClNO/c1-9-6-4-2-3-5(7)8-6/h2-4H,1H3
InChIKey
VAVGOGHLNAJECD-UHFFFAOYSA-N
SMILES
C1(Cl)=NC(OC)=CC=C1
CAS DataBase Reference
17228-64-7(CAS DataBase Reference)
NIST Chemistry Reference
Pyridine, 2-chloro-6-methoxy-(17228-64-7)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39-37/39
RIDADR 
2810
WGK Germany 
3
Hazard Note 
Irritant
PackingGroup 
III
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
152730
Product name
2-Chloro-6-methoxypyridine
Purity
98%
Packaging
25g
Price
$114
Updated
2025/07/31
Sigma-Aldrich
Product number
152730
Product name
2-Chloro-6-methoxypyridine
Purity
98%
Packaging
5g
Price
$27
Updated
2023/06/20
TCI Chemical
Product number
C0197
Product name
2-Chloro-6-methoxypyridine
Purity
>98.0%(GC)
Packaging
5g
Price
$16
Updated
2025/07/31
TCI Chemical
Product number
C0197
Product name
2-Chloro-6-methoxypyridine
Purity
>98.0%(GC)
Packaging
25g
Price
$43
Updated
2025/07/31
TRC
Product number
C368740
Product name
2-Chloro-6-methoxy-pyridine
Packaging
5g
Price
$50
Updated
2021/12/16
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2-Chloro-6-methoxypyridine Chemical Properties,Usage,Production

Chemical Properties

Clear colorless to light yellow liquid

Uses

2-Chloro-6-methoxy-pyridine is a reagent used to synthesize imidazo[1,2-a]pyrimidines as functionally selective GABAA ligands. It can also be used to synthesize oxazolidinedione-arylpyridinones as EP3 receptor antagonists.

General Description

The FT-Raman and Fourier transform infrared (FTIR) spectra of 2-Chloro-6-methoxypyridine has been studied.

Synthesis

2402-78-0

67-56-1

17228-64-7

To a stirred solution of 2,6-dichloropyridine (68.9 g, 466 mmol) in methanol (500 mL) was slowly added sodium methanolate (100 g, 1.86 mol) at room temperature. The reaction mixture was stirred continuously at 60°C for 24 hours. After completion of the reaction, the mixture was cooled to room temperature, the reaction was quenched with 2 M aqueous hydrochloric acid and extracted with dichloromethane (CH2Cl2). The organic layers were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to afford 2-chloro-6-methoxypyridine (66.9 g, quantitative yield) as a colorless oil. The product characterization data were as follows: IR (thin film method, cm?1 ): 1599, 1585, 1560, 1468, 1410, 1302, 1265, 1152, 1024, 876, 789; 1H-NMR (CDCl3, 500 MHz) δ: 7.51 (t, J = 7.37 Hz, 1H), 6.90 (d, J = 7.37 Hz, 1H), 6.65 (d, J = 7.37 Hz, 1H), 3.94 (s, 3H); 13C-NMR (CDCl3, 125 MHz) δ: 163.9, 148.4, 140.5, 116.2, 109.1, 54.0; HR-MS (ESI-TOF): the calculated C6H7ClNO [(M + H)+] value was 144.0211 and the measured value was 144.0211.

References

[1] Chemical and Pharmaceutical Bulletin, 2016, vol. 64, # 7, p. 723 - 732
[2] Patent: CN107935922, 2018, A. Location in patent: Paragraph 0036-0038; 0039-0040; 0045-0048; 0059-0061
[3] Patent: CN106905229, 2017, A. Location in patent: Paragraph 0022; 0023
[4] Chemical & Pharmaceutical Bulletin, 1986, vol. 34, # 9, p. 3658 - 3671
[5] Patent: CN107954928, 2018, A. Location in patent: Paragraph 0017; 0018; 0019; 0020; 0021

2-Chloro-6-methoxypyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-6-methoxypyridine Suppliers

Americas 1 Belgium 4 Canada 1 China 232 Czech Republic 1 Europe 3 France 3 Germany 11 India 29 Ireland 1 Japan 2 Slovakia 1 Switzerland 2 The Netherlands 1 United Kingdom 18 United States 54 Global 364
INTATRADE GmbH
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NovoChemy Ltd.
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CHEMOS GmbH & Co. KG
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View Lastest Price from 2-Chloro-6-methoxypyridine manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
2-Chloro-6-methoxypyridine 17228-64-7
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2025-03-13
Hebei Zhanyao Biotechnology Co. Ltd
Product
2-Chloro-6-methoxypyridine 17228-64-7
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 tons
Release date
2021-10-14
Dideu Industries Group Limited
Product
2-Chloro-6-methoxypyridine 17228-64-7
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-10-22

17228-64-7, 2-Chloro-6-methoxypyridineRelated Search:

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