ChemicalBook > CAS DataBase List > 2,6-Difluoropyridine-4-boronic acid

2,6-Difluoropyridine-4-boronic acid

Product Name
2,6-Difluoropyridine-4-boronic acid
CAS No.
401816-16-8
Chemical Name
2,6-Difluoropyridine-4-boronic acid
Synonyms
2,6-Difluoropyridine-4-boronicaci;2,6-DIFLUORO-4-PYRIDYLBORONIC ACID;2,6-DIFLUOROPYRIDINE-4-BORONIC ACID;(2,6-DIFLUOROPYRIDIN-4-YL)BORONIC ACID;B-(2,6-Difluoro-pyridin-4-yl)boronic acid;B-(2,6-difluoro-4-pyridinyl)-Boronic acid;Boronic acid, B-(2,6-difluoro-4-pyridinyl)-;Boronic acid, (2,6-difluoro-4-pyridinyl)- (9CI);2,6-Difluoropyridine-4-boronic acid ISO 9001：2015 REACH
CBNumber
CB5738508
Molecular Formula
C5H4BF2NO2
Formula Weight
158.9
MOL File
401816-16-8.mol
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2,6-Difluoropyridine-4-boronic acid Property

Boiling point:
334.0±52.0 °C(Predicted)
Density 
1.44±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
pka
5.46±0.11(Predicted)
form 
powder
color 
White
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Safety

Hazard Codes 
Xi
Risk Statements 
37/38-41
Safety Statements 
26-39
Hazard Note 
Irritant
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
D447493
Product name
2,6-Difluoropyridine-4-boronicacid
Packaging
100mg
Price
$75
Updated
2021/12/16
TRC
Product number
D447493
Product name
2,6-Difluoropyridine-4-boronicacid
Packaging
250mg
Price
$140
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD82513
Product name
2,6-Difluoropyridine-4-boronic acid
Packaging
50mg
Price
$70
Updated
2021/12/16
Apolloscientific
Product number
PC7034
Product name
2,6-Difluoropyridine-4-boronicacid
Packaging
100mg
Price
$95
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD82513
Product name
2,6-Difluoropyridine-4-boronic acid
Packaging
100mg
Price
$110
Updated
2021/12/16
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2,6-Difluoropyridine-4-boronic acid Chemical Properties,Usage,Production

Synthesis

903513-58-6

5419-55-6

401816-16-8

The final step in the synthesis of 2,6-difluoropyridine-4-boronic acid involves the lithiation of 2,6-difluoro-4-hydrazinylpyridine followed by reaction with triisopropyl borate. This was done as follows: tetrahydrofuran (150 mL) and toluene (400 mL) were added to the reaction flask. Triisopropyl borate (47 g, 0.25 mol) and 4-bromo-2,6-difluoropyridine (44 g, 0.22 mol) were added to the reaction vessel under nitrogen protection and the mixture was cooled to -75 °C. The reaction was carried out in the reaction vessel with the help of a dosing funnel. n-Butyllithium (2.6 M hexane solution, 105 mL, 0.27 mol) was added slowly dropwise through the addition funnel, with the rate of dropwise acceleration controlled to keep the reaction temperature from exceeding -70 °C. After dropwise addition, stirring was continued at -75 °C for 30 min, after which the cooling bath was removed and the reaction mixture was allowed to warm up to -20 °C naturally. The reaction was quenched with 2N hydrochloric acid (~120 mL), pH adjusted to 2, and stirred for 30 minutes. The organic phase was separated and the aqueous phase was extracted twice with ether (250 mL x 2). The organic phases were combined, washed sequentially with water (500 mL) and brine (250 mL), dried over anhydrous magnesium sulfate, decolorized by the addition of activated charcoal for 1 h, filtered through diatomaceous earth and concentrated under reduced pressure. Hexane (250 mL) was added to the residue to precipitate the solid product. The mixture was refrigerated overnight, the solid was collected by filtration, washed with cold hexane and dried. Since 1H NMR analysis showed butylboronic acid impurities in the product, the solid was stirred with hexane (250 mL) at 45 °C for 30 min, hot filtered and washed with cold hexane to give 11.8 g (33% yield) of the target product 2,6-difluoropyridine-4-boronic acid.1H NMR (DMSO-d6, 400 MHz): δ 7.31 (s, 2H).

References

[1] Patent: US7087755, 2006, B1. Location in patent: Page/Page column 5

2,6-Difluoropyridine-4-boronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2,6-Difluoropyridine-4-boronic acid Suppliers

China 69 Europe 3 Germany 2 India 1 Japan 1 United Kingdom 2 United States 13 Global 91
Alchem Pharmtech,Inc.
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View Lastest Price from 2,6-Difluoropyridine-4-boronic acid manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2,6-Difluoropyridine-4-boronic acid 401816-16-8
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-26
Career Henan Chemical Co
Product
2,6-Difluoropyridine-4-boronic acid 401816-16-8
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg,5kg,50kg
Release date
2020-01-18
Nanjing jinheyou Trading Co., Ltd.
Product
2,6-Difluoropyridine-4-boronic acid 401816-16-8
Price
US $0.00/g
Min. Order
1g
Purity
95%min
Supply Ability
20kg/month
Release date
2019-12-19

401816-16-8, 2,6-Difluoropyridine-4-boronic acidRelated Search:

Flupirtine 2,6-Lutidine Fluoroboric acid 2-Fluoropyridine-4-boronic acid Ammonium fluoborate Sodium tetrafluoroborate Potassium tetrafluoroborate 2,6-Difluoropyridine Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate 2,6-DIFLUORO-3-(4,4,5,5-TETRAMETHYL-[1,3,2]-DIOXABOROLAN-2-YL)PYRIDINE 2,6-DIFLUOROPYRIDINE-3-BORONIC ACID Pyridine-4-boronic acid 2,6-DIFLUOROPYRIDINE-3-BORONIC ACID HYDRATE 3,5-DIFLUOROPYRIDINE-4-BORONIC ACID 3,5-DIFLUOROPYRIDINE-4-BORONIC ACID HYDRATE 3,5-DIFLUOROPYRIDINE-4-BORONIC ACID PINACOL ESTER 2,3-DIFLUOROPYRIDINE-5-BORONIC ACID PINACOL ESTER 2,6-DIFLUOROPYRIDINE-3-BORONIC ACID, PINACOL ESTER

  • 2,6-DIFLUORO-4-PYRIDYLBORONIC ACID
  • (2,6-DIFLUOROPYRIDIN-4-YL)BORONIC ACID
  • 2,6-DIFLUOROPYRIDINE-4-BORONIC ACID
  • Boronic acid, (2,6-difluoro-4-pyridinyl)- (9CI)
  • B-(2,6-difluoro-4-pyridinyl)-Boronic acid
  • B-(2,6-Difluoro-pyridin-4-yl)boronic acid
  • Boronic acid, B-(2,6-difluoro-4-pyridinyl)-
  • 2,6-Difluoropyridine-4-boronicaci
  • 2,6-Difluoropyridine-4-boronic acid ISO 9001：2015 REACH
  • 401816-16-8
  • C5H4BF2NO2
  • HALIDE
  • BORONICACID
  • Boronic acid
  • Organoborons
  • Pyridine
  • Pyridines