N-Ethylmaleimide
- Product Name
- N-Ethylmaleimide
- CAS No.
- 128-53-0
- Chemical Name
- N-Ethylmaleimide
- Synonyms
- NEM;1-ETHYL-1H-PYRROLE-2,5-DIONE;N-Ethylmaleinimide;1H-Pyrrole-2,5-dione, 1-ethyl-;NEMI;NSC 7638;N-Ethylm;NEMI/NEM;usafb-121;USAF B-121
- CBNumber
- CB5748314
- Molecular Formula
- C6H7NO2
- Formula Weight
- 125.13
- MOL File
- 128-53-0.mol
N-Ethylmaleimide Property
- Melting point:
- 43-46 °C(lit.)
- Boiling point:
- 210 °C(lit.)
- Density
- 1.2500 (rough estimate)
- refractive index
- 1.4430 (estimate)
- Flash point:
- 73 °C
- storage temp.
- 2-8°C
- solubility
- methanol: 1 M at 20 °C, clear, colorless
- pka
- -2.18±0.20(Predicted)
- form
- Crystalline Powder
- color
- White to off-white
- Water Solubility
- 1 g/L (20 ºC)
- Sensitive
- Light Sensitive
- Merck
- 14,3822
- BRN
- 112448
- Stability:
- Stable. Combustible. Incompatible with strong oxidizing agents. Refrigerate.
- InChIKey
- HDFGOPSGAURCEO-UHFFFAOYSA-N
- CAS DataBase Reference
- 128-53-0(CAS DataBase Reference)
- NIST Chemistry Reference
- 1H-pyrrole-2,5-dione, 1-ethyl-(128-53-0)
- EPA Substance Registry System
- N-Ethylmaleimide (128-53-0)
Safety
- Hazard Codes
- T+
- Risk Statements
- 21-28-34-43-20/21
- Safety Statements
- 26-28-36/37/39-45-28A
- RIDADR
- UN 2928 6.1/PG 2
- WGK Germany
- 3
- RTECS
- UX9625000
- F
- 19
- TSCA
- Yes
- HazardClass
- 6.1
- PackingGroup
- II
- HS Code
- 29251900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H300Fatal if swallowed
H311Toxic in contact with skin
H314Causes severe skin burns and eye damage
H317May cause an allergic skin reaction
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
N-Bromosuccinimide Price
- Product number
- 04260
- Product name
- N-Ethylmaleimide
- Purity
- purum p.a., ≥99.0% (HPLC)
- Packaging
- 5G-F
- Price
- $90.2
- Updated
- 2024/03/01
- Product number
- 04260
- Product name
- N-Ethylmaleimide
- Purity
- purum p.a., ≥99.0% (HPLC)
- Packaging
- 25G-F
- Price
- $286
- Updated
- 2024/03/01
- Product number
- 04259
- Product name
- N-Ethylmaleimide
- Purity
- BioUltra, ≥99.0% (HPLC)
- Packaging
- 5g
- Price
- $170
- Updated
- 2024/03/01
- Product number
- 04259
- Product name
- N-Ethylmaleimide
- Purity
- BioUltra, ≥99.0% (HPLC)
- Packaging
- 25g
- Price
- $661
- Updated
- 2024/03/01
- Product number
- 04260
- Product name
- N-Ethylmaleimide
- Purity
- purum p.a., ≥99.0% (HPLC)
- Packaging
- 5G
- Price
- $86.7
- Updated
- 2023/01/07
N-Ethylmaleimide Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
Reagent for the covalent modification of cysteine residues in proteins. NEM gives a clear solution in ethanol at 50 mg/ml. NEM dissolves in water (>50 mg in 4 ml); however, aqueous solutions are unstable. The rate of hydrolysis is pseudo-first order and significantly dependent on pH.
Uses
N-Ethylmaleimide is a protein thiol modifier which inhibits apoptotic DNA fragmentation. It is a sulfhydryl reagent and finds application in experimental biochemical studies as well as in enzymology. It is involved in the modification of cysteine residues in proteins and peptides. It acts as a Michael acceptor and reacts with nucelophiles like thiols. It is employed in the inhibition of Mg2+ dependent internucleosomal DNA fragmentation.
Uses
In cancer research (possible antimitotic activity.)
Definition
ChEBI: N-ethylmaleimide is a member of the class of maleimides that is the N-ethyl derivative of maleimide. It has a role as an EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor, an EC 2.7.1.1 (hexokinase) inhibitor, an EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor and an anticoronaviral agent. It is functionally related to a maleimide.
Hazard
Lachrymator when liquid, a strong irritant.
Biochem/physiol Actions
Augments currents from native M-channels in sympathetic neurons and acts as an opener for KCNQ2, KCNQ4 and KCNQ5 channels.
Safety Profile
Poison by intraperitoneal route. Human mutation data reported. Vapors are hlghly irritating. When heated to decomposition it emits toxic fumes of NOx.
N-Ethylmaleimide Preparation Products And Raw materials
Raw materials
Preparation Products
N-Ethylmaleimide Suppliers
- Tel
- --
- Fax
- --
- info@acros.com
- Country
- Belgium
- ProdList
- 6772
- Advantage
- 81
View Lastest Price from N-Ethylmaleimide manufacturers
- Product
- N-Ethylmaleimide 128-53-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- N-Ethylmaleimide 128-53-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08
- Product
- N-Ethylmaleimide 128-53-0
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-12-19