ChemicalBook > CAS DataBase List > N-Ethylmaleimide
N-Ethylmaleimide
- Product Name
- N-Ethylmaleimide
- CAS No.
- 128-53-0
- Chemical Name
- N-Ethylmaleimide
- Synonyms
- NEM;1-ETHYL-1H-PYRROLE-2,5-DIONE;N-Ethylmaleinimide;1H-Pyrrole-2,5-dione, 1-ethyl-;NEMI;NSC 7638;N-Ethylm;NEMI/NEM;usafb-121;USAF B-121
- CBNumber
- CB5748314
- Molecular Formula
- C6H7NO2
- Formula Weight
- 125.13
- MOL File
- 128-53-0.mol
More
Less
N-Ethylmaleimide Property
- Melting point:
- 43-46 °C(lit.)
- Boiling point:
- 210 °C(lit.)
- Density
- 1.2500 (rough estimate)
- refractive index
- 1.4430 (estimate)
- Flash point:
- 73 °C
- storage temp.
- 2-8°C
- solubility
- methanol: 1 M at 20 °C, clear, colorless
- pka
- -2.18±0.20(Predicted)
- form
- Crystalline Powder
- color
- White to off-white
- Water Solubility
- 1 g/L (20 ºC)
- Sensitive
- Light Sensitive
- Merck
- 14,3822
- BRN
- 112448
- Stability:
- Stable. Combustible. Incompatible with strong oxidizing agents. Refrigerate.
- InChIKey
- HDFGOPSGAURCEO-UHFFFAOYSA-N
- CAS DataBase Reference
- 128-53-0(CAS DataBase Reference)
- NIST Chemistry Reference
- 1H-pyrrole-2,5-dione, 1-ethyl-(128-53-0)
- EPA Substance Registry System
- N-Ethylmaleimide (128-53-0)
More
Less
Safety
- Hazard Codes
- T+
- Risk Statements
- 21-28-34-43-20/21
- Safety Statements
- 26-28-36/37/39-45-28A
- RIDADR
- UN 2928 6.1/PG 2
- WGK Germany
- 3
- RTECS
- UX9625000
- F
- 19
- TSCA
- Yes
- HazardClass
- 6.1
- PackingGroup
- II
- HS Code
- 29251900
More
Less
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H300Fatal if swallowed
H311Toxic in contact with skin
H314Causes severe skin burns and eye damage
H317May cause an allergic skin reaction
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
More
Less
N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 04260
- Product name
- N-Ethylmaleimide
- Purity
- purum p.a., ≥99.0% (HPLC)
- Packaging
- 5G-F
- Price
- $90.2
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 04260
- Product name
- N-Ethylmaleimide
- Purity
- purum p.a., ≥99.0% (HPLC)
- Packaging
- 25G-F
- Price
- $286
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 04259
- Product name
- N-Ethylmaleimide
- Purity
- BioUltra, ≥99.0% (HPLC)
- Packaging
- 5g
- Price
- $170
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 04259
- Product name
- N-Ethylmaleimide
- Purity
- BioUltra, ≥99.0% (HPLC)
- Packaging
- 25g
- Price
- $661
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 04260
- Product name
- N-Ethylmaleimide
- Purity
- purum p.a., ≥99.0% (HPLC)
- Packaging
- 5G
- Price
- $86.7
- Updated
- 2023/01/07
More
Less
N-Ethylmaleimide Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
Reagent for the covalent modification of cysteine residues in proteins. NEM gives a clear solution in ethanol at 50 mg/ml. NEM dissolves in water (>50 mg in 4 ml); however, aqueous solutions are unstable. The rate of hydrolysis is pseudo-first order and significantly dependent on pH.
Uses
N-Ethylmaleimide is a protein thiol modifier which inhibits apoptotic DNA fragmentation. It is a sulfhydryl reagent and finds application in experimental biochemical studies as well as in enzymology. It is involved in the modification of cysteine residues in proteins and peptides. It acts as a Michael acceptor and reacts with nucelophiles like thiols. It is employed in the inhibition of Mg2+ dependent internucleosomal DNA fragmentation.
Uses
In cancer research (possible antimitotic activity.)
Definition
ChEBI: N-ethylmaleimide is a member of the class of maleimides that is the N-ethyl derivative of maleimide. It has a role as an EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor, an EC 2.7.1.1 (hexokinase) inhibitor, an EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor and an anticoronaviral agent. It is functionally related to a maleimide.
Hazard
Lachrymator when liquid, a strong irritant.
Biochem/physiol Actions
Augments currents from native M-channels in sympathetic neurons and acts as an opener for KCNQ2, KCNQ4 and KCNQ5 channels.
Safety Profile
Poison by intraperitoneal route. Human mutation data reported. Vapors are hlghly irritating. When heated to decomposition it emits toxic fumes of NOx.
N-Ethylmaleimide Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
N-Ethylmaleimide Suppliers
- Tel
- 0512-68417696 18306209966
- linda@highfine.com
- Country
- China
- ProdList
- 1407
- Advantage
- 58
- Tel
- 010-82387566 18001021521;
- Fax
- 82387566-801
- sales@mreda.com.cn
- Country
- China
- ProdList
- 10789
- Advantage
- 58
- Tel
- 17753923223
- Fax
- 0539-6222546
- 2805221329@qq.com
- Country
- China
- ProdList
- 1474
- Advantage
- 58
- Tel
- 13417589054 13417589054
- trendseenbio@gmail.com
- Country
- China
- ProdList
- 9470
- Advantage
- 58
- Tel
- 022-83946278 13820503911
- Fax
- 022-83945176
- sales@creasyn.com
- Country
- China
- ProdList
- 993
- Advantage
- 68
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-61259108 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44688
- Advantage
- 61
- Tel
- 010-82967028 13552068683
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 12390
- Advantage
- 60
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14103
- Advantage
- 59
- Tel
- 021-58099652-8005 13585536065
- Fax
- 021-58099609
- bin.wu@shlschem.com
- Country
- China
- ProdList
- 9810
- Advantage
- 59
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 4009903999 13355009207
- Fax
- 0539-6365991
- 3007715519@qq.com
- Country
- China
- ProdList
- 18738
- Advantage
- 57
- Tel
- Fax
- E-Mail Inquiry
- info@syntechem.com
- Country
- China
- ProdList
- 12984
- Advantage
- 57
- Tel
- 400-1166-196 18981987031
- Fax
- 028-84555506 800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 11707
- Advantage
- 57
- Tel
- 400 638 7771
- sales@heowns.com
- Country
- China
- ProdList
- 14435
- Advantage
- 57
- Tel
- 86-21-63210123
- Fax
- 86-21-63290778 86-21-63218885
- sj_scrc@sinopharm.com
- Country
- China
- ProdList
- 9815
- Advantage
- 79
- Tel
- 0731-85526065 13308475853
- ivy@hnhbsj.com
- Country
- China
- ProdList
- 4554
- Advantage
- 62
- Tel
- 0571-82693216
- Fax
- +86-571-82880190
- info@yuhaochemical.com
- Country
- China
- ProdList
- 9387
- Advantage
- 52
- Tel
- 021-021-021-67601398-809-809-809 15221380277
- Fax
- 021-57711696
- marketing_china@spectrumchemical.com
- Country
- China
- ProdList
- 9658
- Advantage
- 60
- Tel
- 0411-62910999 13889544652
- sales@meilune.com
- Country
- China
- ProdList
- 4727
- Advantage
- 58
- Tel
- 4008-755-333 18080918076
- Fax
- 028-86757656
- 800078821@qq.com
- Country
- China
- ProdList
- 9718
- Advantage
- 55
- Tel
- 86-21-34053660
- Fax
- 86-21-34053661
- sale@labgogo.com
- Country
- China
- ProdList
- 9865
- Advantage
- 52
- Tel
- 800-810-5118
- Fax
- +86-10-84193589
- cnchemical@thermofisher.com
- Country
- China
- ProdList
- 17770
- Advantage
- 75
- Tel
- 010-56205725
- Fax
- 010-65763397
- waley188@sohu.com
- Country
- China
- ProdList
- 12335
- Advantage
- 58
- Tel
- 400-810-7969 010-59572699
- Fax
- 010-59572688
- ningzi.li@inno-chem.com.cn
- Country
- China
- ProdList
- 6134
- Advantage
- 55
- Tel
- 025-66099280 17798518460
- Fax
- (1)02557626880
- cfzhang@aikonchem.com
- Country
- China
- ProdList
- 19915
- Advantage
- 55
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 22514
- Advantage
- 55
- Tel
- 400-400-6206333 18521732826
- Fax
- 021-50323701
- market@aladdin-e.com
- Country
- China
- ProdList
- 25003
- Advantage
- 65
- Tel
- 028-87578473
- Fax
- +86 (28) 8757-8473
- ellnn@163.com
- Country
- China
- ProdList
- 50
- Advantage
- 60
- Tel
- 025-84699383-8003 18013301590
- Fax
- 025-84699383-8003
- njduly@126.com
- Country
- China
- ProdList
- 971
- Advantage
- 55
- Tel
- 020-39119399 18927568969
- Fax
- 020-39119999
- isunpharm@qq.com
- Country
- China
- ProdList
- 4674
- Advantage
- 55
- Tel
- 021-021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7783
- Advantage
- 58
- Tel
- 0554-2106669
- Fax
- 0554-2666215
- sales1@kedichem.com
- Country
- China
- ProdList
- 4924
- Advantage
- 55
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 41462
- Advantage
- 60
- Tel
- 86-21-51086038
- Fax
- 86-21-51861608
- Country
- China
- ProdList
- 2930
- Advantage
- 58
- Tel
- 400-1166-196 13458535857
- Fax
- QQ：800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 13350
- Advantage
- 58
- Tel
- 0512-87182056 18013166090
- Fax
- 0512-87182056
- lingling.qi@yacoo.com.cn
- Country
- China
- ProdList
- 7295
- Advantage
- 60
- Tel
- 021-24206007 13764915196
- Fax
- 86-021-23027023
- sales@balmxy.com
- Country
- China
- ProdList
- 6773
- Advantage
- 55
- Tel
- 400-821-5857 021-64326257
- Fax
- 021-64393586 QQ;2798200800
- credit-chem@foxmail.com
- Country
- China
- ProdList
- 5219
- Advantage
- 58
- Tel
- 021-60345187 13671753212
- Fax
- 021-34702061
- lzz841106@aliyun.com
- Country
- China
- ProdList
- 10274
- Advantage
- 55
- Tel
- sales@ahpharmatech.com
- Country
- China
- ProdList
- 5734
- Advantage
- 55
- Tel
- 15221275939 15221275939
- Fax
- 021-50706099
- shenlinxing@macklin.cn
- Country
- China
- ProdList
- 16166
- Advantage
- 55
- Tel
- 0571-+86-571-87396432
- Fax
- 0571-87396431
- sales@jhechem.com
- Country
- China
- ProdList
- 11578
- Advantage
- 59
- Tel
- 13096311329 028-88469284 616445927
- Fax
- 028-88469284
- 616445927@qq.com
- Country
- China
- ProdList
- 2874
- Advantage
- 50
- Tel
- 021-58581007 18019463053
- Fax
- 50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 12346
- Advantage
- 58
- Tel
- 027-59599241 18871490274
- Fax
- 027-59599241
- 1400878000@qq.com
- Country
- China
- ProdList
- 9958
- Advantage
- 58
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51456
- Advantage
- 80
More
Less
View Lastest Price from N-Ethylmaleimide manufacturers
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- N-Ethylmaleimide 128-53-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- N-Ethylmaleimide 128-53-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08
Career Henan Chemical Co
- Product
- N-Ethylmaleimide 128-53-0
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-12-19
128-53-0, N-EthylmaleimideRelated Search:
O-Phthalimide
Bismaleimide
Succinimide
Maleimide
N-Benzylmaleimide
N,N'-1,3-Phenylene bismaleimide
N-Phenylmaleimide
DIALIFOS
N-Succinimidyl 3-maleimidopropionate
3-MALEIMIDOPROPIONIC ACID
4-MALEIMIDOBUTYRIC ACID
3-Maleimidopropionic acid
GMBS
N-PROPYLMALEIMIDE
N-Succinimidyl 6-maleimidohexanoate
N-Butylmaleimide
6-Maleimidocaproic acid
4-MALEIMIDO-TEMPO