LEUKOTRIENE C4 Property

Boiling point:

974.3±65.0 °C(Predicted)

Density 

1.225±0.06 g/cm3(Predicted)

Flash point:

11 °C

storage temp. 

−20°C

solubility 

50mg/mL in DMSO, or in DMF

form 

Liquid

pka

2.21±0.10(Predicted)

Safety

Hazard Codes 

F,T

Risk Statements 

11-23/24/25-39/23/24/25

Safety Statements 

36/37-45-16-7

RIDADR 

UN 1230 3/PG 2

WGK Germany 

1

RTECS 

MB9143500

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

LEUKOTRIENE C4 Chemical Properties,Usage,Production

Description

Leukotriene C₄ (LTC₄) is the parent cysteinyl leukotriene produced by the LTC₄ synthase catalyzed conjugation of glutathione to LTA₄. LTC₄ is produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC₄-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute allergic hypersensitivity. The concentration of LTC₄ required to produce marked contractions of lung parenchymal strips and isolated tracheal rings is about 1 nM.

Uses

LTC4 (Leukotriene C4) is a potent agonist for contraction of smooth muscle, wtih many important immunomodulatory functions.

Definition

ChEBI: A leukotriene that contains cysteine in their structure.