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14,15-LEUKOTRIENE C4

Product Name
14,15-LEUKOTRIENE C4
CAS No.
75290-60-7
Chemical Name
14,15-LEUKOTRIENE C4
Synonyms
EXC4;EOXIN C4;14,15-LTC4;14,15-LEUKOTRIENE C4;OBQVBASHEWLKCQ-PKBWNXTMSA-N;Glycine, L-γ-glutamyl-S-[(1R,2E,4E,6Z,9Z)-13-carboxy-1-[(1S)-1-hydroxyhexyl]-2,4,6,9-tridecatetraen-1-yl]-L-cysteinyl-
CBNumber
CB0196624
Molecular Formula
C30H47N3O9S
Formula Weight
625.77
MOL File
75290-60-7.mol
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14,15-LEUKOTRIENE C4 Property

storage temp. 
Store at -20°C
solubility 
DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 100 μg/ml
form 
Liquid.
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10011360
Product name
14,15-Leukotriene C4
Purity
≥95%
Packaging
25μg
Price
$127
Updated
2024/03/01
Cayman Chemical
Product number
10011360
Product name
14,15-Leukotriene C4
Purity
≥95%
Packaging
50μg
Price
$236
Updated
2024/03/01
Cayman Chemical
Product number
10011360
Product name
14,15-Leukotriene C4
Purity
≥95%
Packaging
100μg
Price
$447
Updated
2024/03/01
TRC
Product number
L330368
Product name
14,15-LeukotrieneC4
Packaging
25μg
Price
$125
Updated
2021/12/16
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14,15-LEUKOTRIENE C4 Chemical Properties,Usage,Production

Description

Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase (5-LO) pathway. 14,15-LTC4 is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-LOs on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. 14,15-LTC4 is classified as an eoxin, because it is formed mostly by eosinophils. However, mast cells and nasal polyps can synthesize 14,15-LTC4 as well. Little is known about the physiological actions of 14,15-LTC4. It has weak contractile activity on both guinea pig ileum and pulmonary parenchyma in contrast to the effects of 5-LO-derived LTs. However, in an in vitro permeability assay, 14,15-LTC4 can increase vascular permeability of human endothelial cell monolayers, with similar potency to that of 5-LO-derived LTs resulting in plasma leakage - a hallmark of inflammation.

Uses

14,15-Leukotriene C4 is an acute inflammatory mediator.

References

[1] M LUO  T G B  S Lee. Leukotriene synthesis by epithelial cells.[J]. Histology and histopathology, 2003, 18 2: 587-595. DOI: 10.14670/hh-18.587
[2] C. YOKOYAMA. Arachidonate 12-lipoxygenase purified from porcine leukocytes by immunoaffinity chromatography and its reactivity with hydroperoxyeicosatetraenoic acids.[J]. The Journal of Biological Chemistry, 1986, 61 1: 16714-16721. DOI: 10.1016/s0021-9258(18)66623-2
[3] R. BRYANT. Leukotriene formation by a purified reticulocyte lipoxygenase enzyme. Conversion of arachidonic acid and 15-hydroperoxyeicosatetraenoic acid to 14, 15-leukotriene A4.[J]. The Journal of Biological Chemistry, 1985, 43 1: 3548-3555. DOI: 10.1016/s0021-9258(19)83657-8
[4] STINA FELTENMARK. Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2008: 680-685. DOI: 10.1073/pnas.0710127105
[5] SAILESH S. Sheep Uterus Dual Lipoxygenase in the Synthesis of 14,15-Leukotrienes[J]. Archives of biochemistry and biophysics, 1994, 315 2: Pages 362-368. DOI: 10.1006/abbi.1994.1512
[6] J M DRAZEN. Contractile activities of structural analogs of leukotrienes C and D: necessity of a hydrophobic region.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1981, 78 5: 3195-3198. DOI: 10.1073/pnas.78.5.3195
[7] A SALA. Contractile and binding activities of structural analogues of LTC4 in the longitudinal muscle of guinea-pig ileum.[J]. Eicosanoids, 1990, 3 2: 105-110.

14,15-LEUKOTRIENE C4 Preparation Products And Raw materials

Raw materials

Preparation Products

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14,15-LEUKOTRIENE C4 Suppliers

China 27 Germany 1 United States 3 Global 31
Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
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info@efebio.com
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China
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Shanghai Hongye Biotechnology Co. Ltd
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400-9205774
Email
sales@glpbio.cn
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China
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6777
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767
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QQ 3610331285
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sales@chemegen.com
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China
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11218
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Energy Chemical
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021-58432009 400-005-6266
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021-58436166
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marketing@energy-chemical.com
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China
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Shanghai Yiyan Biotechnology Co. , Ltd.
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021-69985186 13611928337
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3427709316@qq.com
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China
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TargetMol Chemicals Inc.
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15002134094
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marketing@targetmol.cn
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China
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29423
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Cayman Chemical Company
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800-364-9897
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sales@caymanchem.com
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China
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6838
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Enzo Biochem Inc
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Enzo Biochem Inc. 13797054060
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Enzoname@qq.com
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China
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Santa Cruz Biotechnology Inc
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021-60936350
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scbt@scbt.com
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China
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Aladdin Scientific
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tp@aladdinsci.com
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United States
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52923
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58

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  • 14,15-LEUKOTRIENE C4
  • 14,15-LTC4
  • EOXIN C4
  • EXC4
  • OBQVBASHEWLKCQ-PKBWNXTMSA-N
  • Glycine, L-γ-glutamyl-S-[(1R,2E,4E,6Z,9Z)-13-carboxy-1-[(1S)-1-hydroxyhexyl]-2,4,6,9-tridecatetraen-1-yl]-L-cysteinyl-
  • 75290-60-7