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14,15-LEUKOTRIENE C4

Product Name
14,15-LEUKOTRIENE C4
CAS No.
75290-60-7
Chemical Name
14,15-LEUKOTRIENE C4
Synonyms
EXC4;EOXIN C4;14,15-LTC4;14,15-LEUKOTRIENE C4;OBQVBASHEWLKCQ-PKBWNXTMSA-N;Glycine, L-γ-glutamyl-S-[(1R,2E,4E,6Z,9Z)-13-carboxy-1-[(1S)-1-hydroxyhexyl]-2,4,6,9-tridecatetraen-1-yl]-L-cysteinyl-
CBNumber
CB0196624
Molecular Formula
C30H47N3O9S
Formula Weight
625.77
MOL File
75290-60-7.mol
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14,15-LEUKOTRIENE C4 Property

storage temp. 
Store at -20°C
solubility 
DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 100 μg/ml
form 
Liquid.
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10011360
Product name
14,15-Leukotriene C4
Purity
≥95%
Packaging
25μg
Price
$127
Updated
2024/03/01
Cayman Chemical
Product number
10011360
Product name
14,15-Leukotriene C4
Purity
≥95%
Packaging
50μg
Price
$236
Updated
2024/03/01
Cayman Chemical
Product number
10011360
Product name
14,15-Leukotriene C4
Purity
≥95%
Packaging
100μg
Price
$447
Updated
2024/03/01
TRC
Product number
L330368
Product name
14,15-LeukotrieneC4
Packaging
25μg
Price
$125
Updated
2021/12/16
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14,15-LEUKOTRIENE C4 Chemical Properties,Usage,Production

Description

Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase (5-LO) pathway. 14,15-LTC4 is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-LOs on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. 14,15-LTC4 is classified as an eoxin, because it is formed mostly by eosinophils. However, mast cells and nasal polyps can synthesize 14,15-LTC4 as well. Little is known about the physiological actions of 14,15-LTC4. It has weak contractile activity on both guinea pig ileum and pulmonary parenchyma in contrast to the effects of 5-LO-derived LTs. However, in an in vitro permeability assay, 14,15-LTC4 can increase vascular permeability of human endothelial cell monolayers, with similar potency to that of 5-LO-derived LTs resulting in plasma leakage - a hallmark of inflammation.

Uses

14,15-Leukotriene C4 is an acute inflammatory mediator.

14,15-LEUKOTRIENE C4 Preparation Products And Raw materials

Raw materials

Preparation Products

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75290-60-7, 14,15-LEUKOTRIENE C4Related Search:

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  • 14,15-LEUKOTRIENE C4
  • 14,15-LTC4
  • EOXIN C4
  • EXC4
  • OBQVBASHEWLKCQ-PKBWNXTMSA-N
  • Glycine, L-γ-glutamyl-S-[(1R,2E,4E,6Z,9Z)-13-carboxy-1-[(1S)-1-hydroxyhexyl]-2,4,6,9-tridecatetraen-1-yl]-L-cysteinyl-
  • 75290-60-7