ChemicalBook > CAS DataBase List > 4-Thiazolecarboxylic acid

4-Thiazolecarboxylic acid

Product Name
4-Thiazolecarboxylic acid
CAS No.
3973-08-8
Chemical Name
4-Thiazolecarboxylic acid
Synonyms
THIAZOLE-4-CARBOXYLIC ACID;3973/8/8;NSC 195467;AKOS BB-9161;4-CARBOXYTHIAZOLE;TIMTEC-BB SBB010166;4-Carboxy-1,3-thiazole;4-THIAZOLECARBOXYLIC ACID;4-Thiazolecarboxylic acid 97%;1,3-THIAZOLE-4-CARBOXYLIC ACID
CBNumber
CB5769438
Molecular Formula
C4H3NO2S
Formula Weight
129.14
MOL File
3973-08-8.mol
More
Less

4-Thiazolecarboxylic acid Property

Melting point:
195-199 °C (lit.)
Boiling point:
191 °C
Density 
1.525±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
3.57±0.10(Predicted)
color 
White to Off-White
λmax
230nm(EtOH)(lit.)
InChI
InChI=1S/C4H3NO2S/c6-4(7)3-1-8-2-5-3/h1-2H,(H,6,7)
InChIKey
HMVYYTRDXNKRBQ-UHFFFAOYSA-N
SMILES
S1C=C(C(O)=O)N=C1
CAS DataBase Reference
3973-08-8(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
43
Safety Statements 
36/37
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29341000
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
633658
Product name
4-Thiazolecarboxylic acid
Purity
97%
Packaging
1g
Price
$22.61
Updated
2025/07/31
Sigma-Aldrich
Product number
633658
Product name
4-Thiazolecarboxylic acid
Purity
97%
Packaging
5g
Price
$93.8
Updated
2025/07/31
TCI Chemical
Product number
T2494
Product name
Thiazole-4-carboxylic Acid
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$71
Updated
2025/07/31
TCI Chemical
Product number
T2494
Product name
Thiazole-4-carboxylic Acid
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$210
Updated
2025/07/31
TRC
Product number
T344195
Product name
4-Thiazolecarboxylic acid
Packaging
10g
Price
$950
Updated
2021/12/16
More
Less

4-Thiazolecarboxylic acid Chemical Properties,Usage,Production

Chemical Properties

Pale yellow to white solid

Uses

4-Thiazolecarboxylic Acid (cas# 3973-08-8) is a compound useful in organic synthesis.

Synthesis

693-95-8

3973-08-8

The general procedure for the synthesis of thiazole-4-carboxylic acid from 4-methylthiazole was as follows: 4-methylthiazole (19.8 g, 0.2 mol), 200 mL of water, and potassium permanganate (173.8 g, 1.1 mol) were added to a 500 mL three-necked flask, which was heated to 55 °C with stirring and kept for 22 hours. After completion of the reaction, the reaction mixture was cooled and filtered. The filter cake (mainly composed of manganese dioxide) was washed with hot water at 50°C. The filtrate was adjusted to pH 3 with dilute hydrochloric acid, precipitated as a solid and filtered. The filter cake was washed with a small amount of water and dried to give 18.1 g of thiazole-4-carboxylic acid in 70.2% yield, melting point 196-198 °C.

References

[1] Angewandte Chemie, 1992, vol. 104, # 6, p. 748 - 749
[2] Patent: CN104557902, 2018, B. Location in patent: Paragraph 0063; 0076; 0081; 0088; 0089; 0102

4-Thiazolecarboxylic acid Preparation Products And Raw materials

Raw materials

THIOFORMAMIDE Pyruvic acid Methyl Bromopyruvate METHYL 4-THIAZOLECARBOXYLATE 1,2-Dimethoxyethane

Preparation Products

More
Less

4-Thiazolecarboxylic acid Suppliers

Belgium 1 Canada 1 China 247 France 1 Germany 7 India 7 Japan 4 Russia 1 Slovakia 1 South Korea 1 Switzerland 1 The Netherlands 1 United Kingdom 17 United States 34 Global 324
Cangzhou Huiying Pharmaceutical Technology Co. , Ltd.
Tel
15532866377
Email
294989518@qq.com
Country
China
ProdList
20
Advantage
58
Shanghai Chemical Pharm-Intermediate Tech.Co., Ltd.
Tel
21-54820552 18964669552
Fax
086-21-64964478
Email
188738128@qq.com
Country
China
ProdList
310
Advantage
66
Xishi Chemical (Shanghai) Co., Ltd.
Tel
021-60499358 13661956116
Fax
+86 (21) 5106-9359
Email
info@cs-pharm.com
Country
China
ProdList
223
Advantage
58
Yancheng Schiemann Biological Technology Co.,Ltd
Tel
515-88280676 18921872653
Email
sales@ximanbio.com
Country
China
ProdList
1524
Advantage
56
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
Advantage
55
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
Country
China
ProdList
2572
Advantage
57
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Beijing Ouhe Technology Co., Ltd
Tel
010-010-82967028 13522913783
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12000
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9310
Advantage
66
Yaqee Industrial Corporation Limited
Tel
+86-561-5269788, 5209788
Fax
+86-561-5209268
Country
China
ProdList
40
Advantage
66
ZEROSCHEM.CO.,LTD.
Tel
10-61256048 13810278579
Fax
+86 10 61256049
Email
sales@zeroschem.com
Country
China
ProdList
1371
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
Santai Labs, Inc.
Tel
519-85601385
Fax
+86 519 8560 1389
Email
marketing@santailabs.com
Country
China
ProdList
891
Advantage
62
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Tongchuang Pharma(Suzhou). Co., Ltd.
Tel
0512-63263366 18912765016
Fax
0512-6326 3366
Email
tongtf110@sina.com
Country
China
ProdList
993
Advantage
62
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
6387
Advantage
52
Suzhou Chukai PharmaTech
Tel
0512-88812066 15062531973;
Fax
86-512-63926099
Email
wenlongfcb@qq.com
Country
China
ProdList
111
Advantage
62
Shanghai Topbiochem Technology Co., Ltd
Tel
+86-21-60341587
Fax
+86-21-61294319
Email
sales@topbiochem.com
Country
China
ProdList
6175
Advantage
58
Nanjing Norris-Pharm Technology Co., Ltd
Tel
18652989687
Fax
+86-25-52131256
Email
sales@norris-pharm.com
Country
China
ProdList
8878
Advantage
55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19913
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22514
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9546
Advantage
55
shanghai cooperpharm co.,LTD .
Tel
+86-021-58975553
Fax
+86-021-58975554
Email
sales@cooperpharm.com
Country
China
ProdList
1210
Advantage
56
Shanghai Witofly Chemical Co.,Ltd
Tel
Email
sales@witofly.com
Country
China
ProdList
2864
Advantage
52
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7865
Advantage
55
Shanghai Huikai Chemical Technology Co., Ltd.
Tel
021-61995394 18916691159
Email
chemicalsea@163.com
Country
China
ProdList
1972
Advantage
58
Chimica Laboratories Co., Ltd
Tel
0086-573-82585213
Fax
0086-573-82585233
Email
bai@chimicalabs.com
Country
China
ProdList
861
Advantage
64
Aloespharm Co., Ltd.
Tel
021-20960837
Fax
021-20960837
Email
market@aloespharm.com
Country
China
ProdList
1302
Advantage
55
Nanjing Credit Trading Co.,Ltd
Tel
025-52164950
Fax
025-86800069
Email
Googlexu_0114@sina.com
Country
China
ProdList
644
Advantage
58
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
ShangHai D&B Biological Science and Technology Co.Ltd
Tel
400-008-9730,021-54359730 400-008-9730
Fax
021-54353864
Email
info@chemxyz.com
Country
China
ProdList
3057
Advantage
60
Shanghai Worldyang Chemical Co.,Ltd.
Tel
021-021-56795766
Fax
+86-21-56795266
Email
sales@worldyachem.com
Country
China
ProdList
9476
Advantage
58
Chongqing Xingcan Pharmaceutical Technology Co., Ltd.
Tel
023-13650506873 19923294409
Email
xingcanyaoye@sina.com
Country
China
ProdList
1604
Advantage
58
Modachem Shanghai Co., Ltd
Tel
+86 (0)21 51320687 51371369 1744605818
Fax
+86 (0)21 51371369
Country
China
ProdList
1578
Advantage
58
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10263
Advantage
55
Tianjin Anhao Biological Technology Co., Ltd.
Tel
Email
sales@ahpharmatech.com
Country
China
ProdList
5734
Advantage
55
SHANGHAI BANGCHENG CHEMICAL Co.,Ltd.
Tel
021-69106960 13701823733
Fax
021-69106780
Email
13701823733@163.com
Country
China
ProdList
4641
Advantage
60
Shanghai HuanChuan Industry Co.,Ltd.
Tel
021-61478794
Fax
021-61478794
Email
sales@hcshhai.com
Country
China
ProdList
9793
Advantage
50
Shanghai Jovan Biochemical Technology Co. Ltd.
Tel
+86-021-61654350
Fax
+86-021-61654350
Email
1245958370@qq.com
Country
China
ProdList
2982
Advantage
50
Shanghai Song Yuan Chemical Technology Co., Ltd.
Tel
010-1234567 18521000990
Fax
86-021-33275113
Email
sonyuanchemical@163.com
Country
China
ProdList
6479
Advantage
50
Beijing Xinsavi Chemical Technology Co., Ltd.
Tel
010-56218822 13717722232
Fax
010-56218800
Email
xinsavichem@163.com
Country
China
ProdList
3201
Advantage
56
Beijing Holiyang Chemical Co. Ltd.
Tel
13718199399
Fax
QQ : 206661479
Email
holiyangchem@163.com
Country
China
ProdList
3280
Advantage
56
Shanghai YouPeng Chemical Co. Ltd.
Tel
021-69005955 13701776567
Fax
021-69005775
Email
youpengchem@163.com
Country
China
ProdList
4161
Advantage
56
More
Less

View Lastest Price from 4-Thiazolecarboxylic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
4-Thiazolecarboxylic acid 3973-08-8
Price
US $9.90/KG
Min. Order
100KG
Purity
99%
Supply Ability
100 mt
Release date
2024-12-03
Shaanxi Dideu Medichem Co. Ltd
Product
4-Thiazolecarboxylic acid 3973-08-8
Price
US $0.00-0.00/KG
Min. Order
1g
Purity
99%
Supply Ability
2000tons
Release date
2019-12-31
Career Henan Chemical Co
Product
4-Thiazolecarboxylic acid 3973-08-8
Price
US $8.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
100KG
Release date
2018-12-15

3973-08-8, 4-Thiazolecarboxylic acidRelated Search:

2-(2-Aminothiazol-4-yl)glyoxylic acid 2-Mercaptobenzothiazole Thiazole Benzothiazole 2,2'-Dithiobis(benzothiazole) Fosthiazate Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) 5-THIAZOLECARBOXYLIC ACID Thiazole-4-carboxaldehyde THIAZOLE-2-CARBOXYLIC ACID THIAZOLE-4-CARBOXAMIDE 4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID Ethyl thiazole-5-carboxylate 2-THIAZOLE-4-BORONIC ACID THIAZOLO[5,4-B]PYRIDIN-2-AMINE Ethyl thiazole-2-carboxylate thiazol-4-ylboronic acid pinacol ester C-THIAZOL-4-YL-METHYLAMINE HYDROCHLORIDE

  • 4-Thiazolecarboxylic acid 3973-8-8
  • 1,3-Thiazole-4-Carboxylic Acid 3973-8-8
  • 1,3-thiazole-4-carboxylic acid(SALTDATA: FREE)
  • 4-Carboxy-1,3-thiazole
  • NSC 195467
  • 4-Thiazolecarboxylic acid 97%
  • 4-Thiazolecarboxylic Acid, 97+%
  • 3973/8/8
  • 1,3-THIAZOLE-4-CARBOXYLIC ACID
  • AKOS BB-9161
  • 4-CARBOXYTHIAZOLE
  • 4-THIAZOLECARBOXYLIC ACID
  • TIMTEC-BB SBB010166
  • THIAZOLE-4-CARBOXYLIC ACID
  • 3973-08-8
  • 3937-08-8
  • 3973-08-6
  • 3973-8-8
  • 3973/8/8
  • 757-36-9
  • C4H3NO2S
  • Building Blocks
  • Thiazoles
  • Heterocyclic Building Blocks
  • Carboxylic Acids
  • Thiazoles, Isothiazoles & Benzothiazoles
  • Thiazoles
  • Sulphur Derivatives
  • Carboxylic Acids
  • Thiazoles, Isothiazoles &Benzothiazoles
  • Heterocycles
  • Miscellaneous Reagents
  • Sulfur & Selenium Compounds
  • Building Blocks
  • Heterocyclic Building Blocks
  • blocks
  • Carboxes
  • bc0001