3,4-DIHYDROQUINOLIN-2(1H)-ONE

Product Name: 3,4-DIHYDROQUINOLIN-2(1H)-ONE
CAS No.: 553-03-7
Chemical Name: 3,4-DIHYDROQUINOLIN-2(1H)-ONE
Synonyms: 3,4-DIHYDRO-1H-QUINOLIN-2-ONE;HYDROCARBOSTYRIL;3,4-DIHYDRO-2(1H)-QUINOLINONE;inone;DIHYDROCARBOSTYRIL;dihydro-α-quinolone;3,4-Dihydrocarbostyril;3,4-Dihydro-2-quinolone;3,4-Dihydro-2(1H)-quinoL;3,4-Dihydro-2-quinolinone
CBNumber: CB5772351
Molecular Formula: C9H9NO
Formula Weight: 147.17
MOL File: 553-03-7.mol

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3,4-DIHYDROQUINOLIN-2(1H)-ONE Property

Melting point:: 165-167 °C (lit.)
Boiling point:: 267.28°C (rough estimate)
Density: 1.1135 (rough estimate)
refractive index: 1.5200 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml
form: Crystalline Powder
pka: 14.76±0.20(Predicted)
color: Off-white
Water Solubility: Slightly soluble in water.
Sensitive: Light Sensitive
Merck: 13,4800
CAS DataBase Reference: 553-03-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38-43
Safety Statements: 26-36/37
RIDADR: 2811
WGK Germany: 2
Hazard Note: Irritant
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 29337900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H301Toxic if swalloed

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 415936
Product name: 3,4-Dihydro-2(1H)-quinolinone
Purity: 98%
Packaging: 10g
Price: $171
Updated: 2023/06/20

Sigma-Aldrich

Product number: 415936
Product name: 3,4-Dihydro-2(1H)-quinolinone
Purity: 98%
Packaging: 1g
Price: $39.4
Updated: 2023/01/07

Alfa Aesar

Product number: H36638
Product name: 3,4-Dihydro-2-(1H)-quinolinone, 98%
Packaging: 1g
Price: $42.65
Updated: 2024/03/01

Alfa Aesar

Product number: H36638
Product name: 3,4-Dihydro-2-(1H)-quinolinone, 98%
Packaging: 5g
Price: $128.65
Updated: 2024/03/01

Alfa Aesar

Product number: H36638
Product name: 3,4-Dihydro-2-(1H)-quinolinone
Purity: 98%
Packaging: 25g
Price: $440
Updated: 2021/12/16

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3,4-DIHYDROQUINOLIN-2(1H)-ONE Chemical Properties,Usage,Production

Chemical Properties

Off-white crystalline powder

Uses

3,4-Dihydro-2-(1H)-quinolinone may be employed as medium supplement in the culture medium of Pseudomonas ayucida during enrichment culture experiments. It is used to prepare potent bicyclic peptide deformylase inhibitors with antibacterial effects. It is also used to synthesize substituted iminopiperidines as inhibitors of human nitric oxide synthase isoforms.

Uses

3,4-Dihydro-2(1H)-quinolinone may be employed as medium supplement in the culture medium of Pseudomonas ayucida during enrichment culture experiments.

Definition

ChEBI: 3,4-Dihydro-2(1H)-quinolinone is a member of quinolines.

Synthesis Reference(s)

Journal of the American Chemical Society, 89, p. 7131, 1967 DOI: 10.1021/ja01002a061
Tetrahedron Letters, 36, p. 125, 1995 DOI: 10.1016/0040-4039(94)02191-D

General Description

Series of 3,4-dihydro-2(1H)-quinolinone derivatives having sigma-1 receptor (σ1R) antagonist activity have been synthesized. 3,4-dihydro-2((1)H)-quinolinones have been synthesized using N-(1′-alkoxy)cyclopropyl-2-haloanilines as starting reagent. Cyclopropane ring expansion in the presence of palladium catalyst is the major step involved in the synthesis. Library of 3,4-dihydro-2(1H)-quinolinones have been synthesized through the rearrangement of β-lactam intermediates on the solid-phase

3,4-DIHYDROQUINOLIN-2(1H)-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

Cilostazol VESNARINONE

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3,4-DIHYDROQUINOLIN-2(1H)-ONE Suppliers

China 134 Czech Republic 1 France 1 Germany 1 India 3 Japan 2 Slovakia 1 Switzerland 1 Ukraine 1 United Kingdom 13 United States 30 Global 188

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View Lastest Price from 3,4-DIHYDROQUINOLIN-2(1H)-ONE manufacturers

Hebei Zhanyao Biotechnology Co. Ltd

Product: 1,2,3,4-Tetrahydroquinolin-2-one 553-03-7
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 tons
Release date: 2021-10-14

Career Henan Chemical Co

Product: 1,2,3,4-Tetrahydroquinolin-2-one 553-03-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kgs
Release date: 2020-02-13

553-03-7, 3,4-DIHYDROQUINOLIN-2(1H)-ONERelated Search:

Tetrahydro-4H-pyran-4-one Naringin dihydrochalcone Isoquinoline Quinhydrone 6-Hydroxy-2(1H)-3,4-dihydroquinolinone Epiandrosterone acetate Dehydroepiandrosterone Dihydromyrcenol Quinclorac 3,4-Dihydro-7-(4-bromobutoxy)-2(1H)-quinolinone 7-HYDROXY-1,2,3,4-TETRAHYDROQUINOLIN-2-ONE 3,4-DIHYDROQUINOLIN-2(1H)-ONE AURORA KA-3413 AURORA KA-6039 AURORA KA-5523 1-BUTYL-3-CHLORO-3-METHYL-1,2,3,4-TETRAHYDROQUINOLINE-2,4-DIONE 3-BENZYL-1-BUTYL-3-CHLORO-1,2,3,4-TETRAHYDROQUINOLINE-2,4-DIONE AURORA KA-3185

HYDROCARBOSTYRIL

DIHYDROCARBOSTYRIL

3,4-DIHYDRO-2(H)-QUINOLINE

3,4-DIHYDRO-2(1H)-QUINOLINONE

3,4-DIHYDRO-2(1H)-QUINOLONE

3,4-DIHYDRO-1H-QUINOLIN-2-ONE

1,2,3,4-Tetrahydroquinolin-2-one

2-OXO-1,2,3,4-TETRAHYDROQUINOLINE

2-OXO-1,3,4-TRIHYDROQUINOLINE

dihydro-α-quinolone

o-aminohydrocinnamic acid lactam

3,4-Dihydrocarbostyril

3,4-DIHYDRO-1H-QUINOLIN-2-ONE, 99+%

2-Oxo-1,2,3,4-tetrahydroquinoline, 3,4-Dihydrocarbostyril

3,4-Dihydroquinolin-2(1H)-one 97%

4-Dihydro-2(1H)-quinolinone

3,4-Dihydro-2-quinolone

1,2,3,4-Tetrahydro-2(1H)-quinolinone

1,2,3,4-Tetrahydro-2-oxoquinoline

3,4-Dihydro-2-quinolinone

1,2,3,4-Tetrahydroquinoline-2-one

3,4-Dihydro-2(1H)-quinolinone,98%

3,4-Dihydro-2(1H)-quinolinoneHydrocarbostyril

2(1H)-Quinolinone, 3,4-dihydro-

3,4-Dihydro-2(1H)-quinolinone, 97+%

3,4-Dihydro-2(1H)-quinolinone 98%

3,4-Dihydro-2(1H)-quinoL

inone

1,2,3,4-Tetrahydroquinolin-2-one ISO 9001：2015 REACH

4-Tetrahydroquinolin-2-one

3,4-DIHYDROQUINOLIN-2(1H)-ONE

553-03-7

C6H4CH2CH2CONH

Building Blocks

Quinolines

Heterocyclic Building Blocks

Quinolines, Isoquinolines & Quinoxalines

Heterocycles

pharmacetical

API intermediates