ChemicalBook > CAS DataBase List > 2-Bromo-5-thiazolecarboxylic acid

2-Bromo-5-thiazolecarboxylic acid

Product Name
2-Bromo-5-thiazolecarboxylic acid
CAS No.
54045-76-0
Chemical Name
2-Bromo-5-thiazolecarboxylic acid
Synonyms
RARECHEM AL BE 1435;2-BROMOTHIAZOLE-5-CARBOXYLIC ACID;2-BROMO-5-THIAZOLECARBOXYLIC ACID;2-BROMOTHAIZOLE-5-CARBOXYLIC ACID;2-BROMO-5-THLAZOLECARBOXYLIC ACID;5-Thiazolecarboxylicacid, 2-broMo-;2-Bromothiazole-5-carboxylicacid,97%;2-Bromothiazole-5-carboxylic acid 97%;2-Bromothiazole-5-carboxylic Acid >2-BROMO-1,3-THIAZOLE-5-CARBOXYLIC ACID
CBNumber
CB5780794
Molecular Formula
C4H2BrNO2S
Formula Weight
208.03
MOL File
54045-76-0.mol
More
Less

2-Bromo-5-thiazolecarboxylic acid Property

Melting point:
182 °C (dec.)
Boiling point:
350.0±15.0 °C(Predicted)
Density 
2.062±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
2.52±0.10(Predicted)
form 
Crystalline Powder
color 
White to off-white
InChI
InChI=1S/C4H2BrNO2S/c5-4-6-1-2(9-4)3(7)8/h1H,(H,7,8)
InChIKey
BESGTWHUMYHYEQ-UHFFFAOYSA-N
SMILES
S1C(C(O)=O)=CN=C1Br
CAS DataBase Reference
54045-76-0(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
43
Safety Statements 
36/37
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
29341000
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
642487
Product name
2-Bromothiazole-5-carboxylic acid
Purity
97%
Packaging
1g
Price
$75
Updated
2023/06/20
Sigma-Aldrich
Product number
642487
Product name
2-Bromothiazole-5-carboxylic acid
Purity
97%
Packaging
5g
Price
$125
Updated
2023/06/20
TCI Chemical
Product number
B4329
Product name
2-Bromothiazole-5-carboxylic Acid
Purity
>97.0%(GC)(T)
Packaging
1g
Price
$49
Updated
2025/07/31
TCI Chemical
Product number
B4329
Product name
2-Bromothiazole-5-carboxylic Acid
Purity
>97.0%(GC)(T)
Packaging
5g
Price
$196
Updated
2025/07/31
TRC
Product number
B688210
Product name
2-Bromothiazole-5-carboxylic acid
Packaging
1g
Price
$120
Updated
2021/12/16
More
Less

2-Bromo-5-thiazolecarboxylic acid Chemical Properties,Usage,Production

Chemical Properties

White to brown solid

Uses

2-Bromothiazole-5-carboxylic acid is used as a reagent to synthesize azole-based protein kinase B inhibitors, some of which have anti-cancer properties.

Synthesis

41731-83-3

54045-76-0

General procedure for the synthesis of 2-bromothiazole-5-carboxylic acid from ethyl 2-bromothiazole-5-carboxylate: an aqueous solution (100 mL) of sodium hydroxide (4.1 g, 102 mmol) was added slowly and dropwise at 0 °C to a solution of tetrahydrofuran (THF, 100 mL) of ethyl 2-bromothiazole-5-carboxylate (20 g, 84.7 mmol). The reaction mixture was stirred continuously at 10 °C for 1 hour. Subsequently, the reaction mixture was neutralized with 6 M hydrochloric acid and extracted with ethyl acetate (3 x 100 mL). The organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 2-bromothiazole-5-carboxylic acid (17.7 g, 100% yield) as a yellow solid. The product was characterized by 1H NMR (400 MHz, DMSO-d6) with chemical shift δ 8.21 (s, 1H).

References

[1] Patent: WO2015/116663, 2015, A1. Location in patent: Paragraph 0103
[2] Patent: US2011/92475, 2011, A1. Location in patent: Page/Page column 14
[3] Helvetica Chimica Acta, 1954, vol. 37, p. 2057,2064
[4] Patent: US6066639, 2000, A

2-Bromo-5-thiazolecarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2-Bromo-5-thiazolecarboxylic acid Suppliers

Americas 1 China 199 Europe 1 Germany 5 India 5 Japan 1 Slovakia 2 Switzerland 3 The Netherlands 2 Ukraine 1 United Kingdom 15 United States 46 Global 281
Changzhou Anchor Biological Technology Co., Ltd
Tel
0519-85519868 18915088878
Fax
0519-85512868
Email
sales@ankerbio.com
Country
China
ProdList
261
Advantage
58
Tianjin Scaxchem Limited Compnay
Tel
18020011318 18630949181
Email
sales@cosychem.com
Country
China
ProdList
642
Advantage
55
Changzhou Xinda Biotechnology Co., Ltd
Tel
0519-85519868 18915088878
Email
xiaoweng106108@163.com
Country
China
ProdList
99
Advantage
58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2338
Advantage
56
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
Shanghai Chemical Pharm-Intermediate Tech.Co., Ltd.
Tel
21-54820552 18964669552
Fax
086-21-64964478
Email
188738128@qq.com
Country
China
ProdList
310
Advantage
66
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9309
Advantage
66
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
16077
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
Shanghai Ennopharm Co., Ltd.
Tel
+86 (21) 6435-5022
Country
China
ProdList
4267
Advantage
65
ChangZhou SIDU chemical Co., Ltd.
Tel
0519-81291281 18015082300
Fax
0519-81291281
Email
siduchem@hotmail.com
Country
China
ProdList
274
Advantage
62
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
Chengdu Green Young Biomedical Technology Co., Ltd.
Tel
86+28-85337952 18081025021
Fax
86+28-85337952
Email
greenyoung@glykj.com
Country
China
ProdList
94
Advantage
62
Shanghai ZaiQi Bio-Tech Co., Ltd.
Tel
021-54824098, 021-37212705 021-37212706, 13391256916
Fax
021-54824069
Email
sales@chemzq.com
Country
China
ProdList
570
Advantage
55
Shanghai Xiannuo Biotechnology Co., Ltd.
Tel
021-50718719 13918719472
Fax
021-50718719
Country
China
ProdList
979
Advantage
58
Suzhou Sibian Chemical Technology Co.,Ltd.
Tel
0512-65617459 18915409046
Fax
0512-65617459
Email
sales@sibian-chem.com
Country
China
ProdList
1922
Advantage
55
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Nanjing Norris-Pharm Technology Co., Ltd
Tel
18652989687
Fax
+86-25-52131256
Email
sales@norris-pharm.com
Country
China
ProdList
8878
Advantage
55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19913
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18209
Advantage
56
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9546
Advantage
55
Cantotech Chemicals, Ltd.
Tel
86-0755-86635001
Fax
86-0755-22642228
Email
cantotech@126.com
Country
China
ProdList
4566
Advantage
55
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7865
Advantage
55
Chengdu Ying Xi Technology Co., Ltd.
Tel
+86-28-87361500 13880902127
Fax
+86-28-87361500
Email
arcche@163.com
Country
China
ProdList
46
Advantage
56
Wuxi Zhangkun Biochemical Technology Co., Ltd.
Tel
+86 0510-85629785
Fax
+86 0510-85625359
Country
China
ProdList
2327
Advantage
58
Chimica Laboratories Co., Ltd
Tel
0086-573-82585213
Fax
0086-573-82585233
Email
bai@chimicalabs.com
Country
China
ProdList
861
Advantage
64
Amatek Scientific Co. Ltd.
Tel
0512-56316828 4008675858
Fax
+86-512-56316826
Email
sales@amateksci.com
Country
China
ProdList
9874
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
ShangHai D&B Biological Science and Technology Co.Ltd
Tel
400-008-9730,021-54359730 400-008-9730
Fax
021-54353864
Email
info@chemxyz.com
Country
China
ProdList
3057
Advantage
60
Chemfun Medical Technology(Shanghai) Co., Ltd.
Tel
021-67220633 021-54824098
Fax
+86-21-54824069
Email
chemfun@chemfun.net
Country
China
ProdList
491
Advantage
58
Hunan HuaTeng Pharmaceutical Co., Ltd.,
Tel
400-8592883
Fax
0731-82251112
Email
sales@huatengsci.com
Country
China
ProdList
5872
Advantage
58
Jiaxing Novartis Chemical Co., Ltd.
Tel
18957373295
Fax
-
Country
China
ProdList
1580
Advantage
58
Credit-Chem Co., Ltd.
Tel
400-821-5857 021-64326257
Fax
021-64393586 QQ;2798200800
Email
credit-chem@foxmail.com
Country
China
ProdList
5219
Advantage
58
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10263
Advantage
55
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
14912
Advantage
59
Credit Asia Chemical Co., Ltd.
Tel
+86 (21) 61124340
Fax
+86 (21) 6129-4103
Country
China
ProdList
9756
Advantage
58
Cool Pharm, Ltd
Tel
021-60455363 18019463053
Fax
50966098
Email
sales@coolpharm.com
Country
China
ProdList
12346
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
Tianjing Geneston Bio-tech Co.,Ltd.
Tel
022-60131465 18920720807
Fax
022-58558581
Email
zishan_1986@163.com
Country
China
ProdList
743
Advantage
58
Quzhou Rundong Chemical (Technology) Co.
Tel
0570-8789886 18892685668
Fax
0570-8789985
Email
info@rundongchemical.com
Country
China
ProdList
4053
Advantage
60
NovoChemy Ltd.
Tel
86-(0)21-31261262 373522135
Fax
86-(0)21-33250524
Email
sales@novochemy.com
Country
China
ProdList
6498
Advantage
58
More
Less

View Lastest Price from 2-Bromo-5-thiazolecarboxylic acid manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2-Bromo-5-thiazolecarboxylic acid 54045-76-0
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-02-26
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-Bromo-5-thiazolecarboxylic acid 54045-76-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-Bromo-5-thiazolecarboxylic acid 54045-76-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

54045-76-0, 2-Bromo-5-thiazolecarboxylic acidRelated Search:

2-Methyl-4-isothiazolin-3-one 4-Bromobenzoic acid 2,2'-Dithiobis(benzothiazole) Methyl 2-bromobenzoate Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) Benzothiazole Ethyl 2-(Chlorosulfonyl)acetate 4-Bromomethylbenzoic acid 2-Bromothiazole Fosthiazate 2-BROMO-4-THIAZOLECARBOXYLIC ACID Ascoric Acid Bromine CARBOXYLIC ACID 2-Bromo-5-thiazolecarboxylic acid

  • 2-Bromo-1,3-thiazole-5-carboxylic acid 97%
  • 2-BROMO-1,3-THIAZOLE-5-CARBOXYLIC ACID
  • 2-BROMO-5-THIAZOLECARBOXYLIC ACID
  • 2-BROMOTHIAZOLE-5-CARBOXYLIC ACID
  • RARECHEM AL BE 1435
  • 2-BROMO-5-THLAZOLECARBOXYLIC ACID
  • 2-BROMOTHAIZOLE-5-CARBOXYLIC ACID
  • 2-Bromothiazole-5-carboxylicacid,97%
  • 2-Bromothiazole-5-carboxylic acid 97%
  • 2-Bromo-1,3-thiazole-5-carboxylicacid97%
  • 5-Thiazolecarboxylicacid, 2-broMo-
  • 2-Bromothiazole-5-carboxylic Acid &gt
  • 54045-76-0
  • 54045-79-0
  • 4045-76-0
  • C4HBrNO2S
  • Thiazoles
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Building Blocks
  • Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • ThiazolesHeterocyclic Building Blocks
  • Carboxylic Acids
  • Thiazoles, Isothiazoles & Benzothiazoles
  • Carboxylic Acids
  • Thiazoles, Isothiazoles &Benzothiazoles
  • Organic acids
  • Building Blocks
  • Thiazole
  • blocks
  • Bromides
  • Carboxes
  • Thiazoles