ChemicalBook > CAS DataBase List > LDN-57444

LDN-57444

Product Name
LDN-57444
CAS No.
668467-91-2
Chemical Name
LDN-57444
Synonyms
CS-988;LDN-57444;UCH-L1 Inhibitor;LDN 57444, >=98%;LDN-57444/LDN57444;LDN-57444 USP/EP/BP;UCH-L1 INHIBITOR;LDN57444;UCH-L1 Inhibitor - CAS 668467-91-2 - Calbiochem;3-(Acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one;(Z)-3-(Acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one
CBNumber
CB5804575
Molecular Formula
C17H11Cl3N2O3
Formula Weight
397.64
MOL File
668467-91-2.mol
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LDN-57444 Property

Boiling point:
534.4±60.0 °C(Predicted)
Density 
1.50±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble16mg/mL
form 
solid
pka
-2.57±0.20(Predicted)
color 
Yellow
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
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Safety

Hazard Codes 
N
Risk Statements 
50/53
Safety Statements 
60-61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
L4170
Product name
LDN-57444
Purity
≥98% (HPLC)
Packaging
5mg
Price
$118
Updated
2024/03/01
Sigma-Aldrich
Product number
662086
Product name
UCH-L1 Inhibitor
Packaging
10mg
Price
$172
Updated
2024/03/01
Cayman Chemical
Product number
15396
Product name
LDN-57444
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
15396
Product name
LDN-57444
Purity
≥95%
Packaging
5mg
Price
$78
Updated
2024/03/01
Sigma-Aldrich
Product number
L4170
Product name
LDN-57444
Purity
≥98% (HPLC)
Packaging
25mg
Price
$470
Updated
2024/03/01
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LDN-57444 Chemical Properties,Usage,Production

Description

The ubiquitin C-terminal hydrolase L1 (UCH-L1) is a member of a family of de-ubiquitinating enzymes that can generate free ubiquitin from ubiquitin precursors via its ubiquitin ligase activity. By associating with free ubiquitin, it also prevents its degradation. Neuronal UCH-L1 has been linked to Parkinson’s disease, the development of tumors, and neuropathic pain. LDN-57444 is an inhibitor of UCH-L1 activity (IC50 = 0.88, Ki = 0.4 μM) that demonstrates selectivity for UCH-L1 compared to UCH-L3 (IC50 = 25 μM). Loss of UCH-L1 activity causes cell death through the apoptosis pathway due to an impaired ubiquitin-proteasome pathway. LDN-57444-induced reduction of free ubiquitin has been shown to create dramatic alterations in synaptic structure and function, increasing spine size while decreasing spine density in hippocampal neurons.

Uses

LDN 57444 is an inhibitor of UCH-L1, an enzyme expressed by certain lung tumor-derived cell lines, suggesting that this enzyme plays a role in tumor progression.

Biochem/physiol Actions

LDN-57444 is a potent, reversible, competitive and active site-directed inhibitor of UCHL1

References

1) Liu et al. (2003), Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line; Chem. Biol., 10 837 2) Tan et al. (2008), Endoplasmic reticulum stress contributes to the cell death induced by UCH-L1 inhibitor; Mol. Cell. Biochem., 318 109 3) Cartier et al. (2009), Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1; J. Neurosci., 29 7857

LDN-57444 Preparation Products And Raw materials

Raw materials

Preparation Products

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LDN-57444 Suppliers

China 84 France 1 India 2 United Kingdom 1 United States 21 Global 109
MedChemexpress LLC
Tel
021-58955995
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609-228-5909
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sales@medchemexpress.cn
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United States
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AdooQ BioScience, LLC
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+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
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United States
ProdList
2784
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Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
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60
Alabiotech Inc.
Tel
001-619-354-5251
Fax
001-855-855-6087
Email
sales@alabiotech-e.com
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United States
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972
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Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
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4662
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TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
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United States
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19892
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58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
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sales@invivochem.cn
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United States
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Cckinase, Inc.
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+1 (732)236-3202
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sales@cckinase.com
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Aladdin Scientific
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+1-+1(833)-552-7181
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sales@aladdinsci.com
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United States
ProdList
57511
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58

668467-91-2, LDN-57444Related Search:

CONCANAMYCIN A 2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione SGC-GAK-1 SALUBRINAL GSK1904529A PR-619 TCID Pemetrexed Disodium Clofarabine SKI II

  • LDN-57444
  • 5-Chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione3-(O-acetyloxime)
  • LDN-57444/LDN57444
  • 1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime)
  • 5-Chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione 3-(O-acetyloxime) LDN 57444
  • 3-(O-acetyloxime), 5-chloro-1-[(2,5-dichlorophenyl)methyl]-1H-Indole-2,3-dione
  • UCH-L1 Inhibitor
  • (Z)-3-(Acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one
  • LDN 57444, >=98%
  • UCH-L1 Inhibitor - CAS 668467-91-2 - Calbiochem
  • CS-988
  • UCH-L1 INHIBITOR;LDN57444
  • LDN-57444 USP/EP/BP
  • 3-(Acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one
  • 668467-91-2
  • Inhibitors