ChemicalBook > CAS DataBase List > Rosmantuzumab
Rosmantuzumab
- Product Name
- Rosmantuzumab
- CAS No.
- 1684393-04-1
- Chemical Name
- Rosmantuzumab
- Synonyms
- OMP-131R10;Rosmantuzumab;Rosmantuzumab (anti-RSPO3);Research Grade Rosmantuzumab;Research Grade Rosmantuzumab (DHJ51101)
- CBNumber
- CB58081006
- Formula Weight
- 0
- MOL File
- Mol file
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Rosmantuzumab Property
- form
- Liquid
- color
- Colorless to light yellow
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Rosmantuzumab Chemical Properties,Usage,Production
Uses
Rosmantuzumab (OMP-131R10) is an anti-R-spondin 3 (RSPO3) humanized monoclonal antibody. Rosmantuzumab can be used for the research of advanced telapsed and refractory solid tumors[1].
in vivo
Rosmantuzumab (25 mg/kg; i.p., once a week for 4 weeks) significantly protects the animals from developing liver fibrosis[1]. Rosmantuzumab (25 mg/kg; i.p., once for two weeks, for total 6 weeks) significantly inhibits skin thickness, collagen deposition, and number of α-SMA positive cells in bleomycin-induced lung fibrosis mouse models[1].
| Animal Model: | Male C57B1/6J CCl4 liver fibrosis mouse models[1] |
| Dosage: | 25 mg/kg |
| Administration: | Intraperitoneal injection; 25 mg/kg, once a week for 4 weeks |
| Result: | Significantly decreased collagen I and collagen III mRNAs, and inhibits β-catenin cytoplasmic and nuclear translocation. |
References
[1] Zhang M, et al. Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs. PLoS One. 2020 Mar 11;15(3):e0229445. DOI:10.1371/journal.pone.0229445
Rosmantuzumab Preparation Products And Raw materials
Raw materials
Preparation Products
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Rosmantuzumab Suppliers
- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
- 57505
- Advantage
- 58
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