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4-[(4-Fluorophenyl)methyl]-2-morpholinemethanamine

Product Name
4-[(4-Fluorophenyl)methyl]-2-morpholinemethanamine
CAS No.
112914-13-3
Chemical Name
4-[(4-Fluorophenyl)methyl]-2-morpholinemethanamine
Synonyms
2-Aminomethy-4-(4-fluorobenzvlmoroholine;2-Aminoethy-4-(4-Fluorobenzyl)-morpholine;2-Aminomethy-4-(4-fluorobenzyl)morpholine;(4-(4-Fluorobenzyl)Morpholin-2-yl)MethanaMine;4-[(4-Fluorophenyl)methyl]-2-morpholinemethamine;2-Aminomethy-4-(4-fluorobenzyl)morpholine, >=98%;4-[(4-Fluorophenyl)methyl]-2-morpholinemethanamine;2-Morpholinemethanamine,4-[(4-fluorophenyl)methyl]-;{4-[(4-fluorophenyl)Methyl]Morpholin-2-yl}MethanaMine;[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methanamine
CBNumber
CB5838259
Molecular Formula
C12H17FN2O
Formula Weight
224.27
MOL File
112914-13-3.mol
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4-[(4-Fluorophenyl)methyl]-2-morpholinemethanamine Property

Boiling point:
317.4±27.0 °C(Predicted)
Density 
1.145±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka
9.37±0.29(Predicted)
form 
Oil
color 
Pale Yellow to Light Yellow
InChI
InChI=1S/C12H17FN2O/c13-11-3-1-10(2-4-11)8-15-5-6-16-12(7-14)9-15/h1-4,12H,5-9,14H2
InChIKey
JHSPPBBJOLKJDH-UHFFFAOYSA-N
SMILES
N1(CC2=CC=C(F)C=C2)CCOC(CN)C1
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Safety

HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC
Product number
A616180
Product name
2-Aminomethyl-4-(4-fluorobenzyl)morpholine
Packaging
1g
Price
$75
Updated
2021/12/16
AK Scientific
Product number
D078
Product name
2-Aminomethyl-4-(4-fluorobenzyl)morpholine
Packaging
1g
Price
$19
Updated
2021/12/16
ChemScene
Product number
CS-W003302
Product name
2-Aminomethyl-4-(4-fluorobenzyl)morpholine
Packaging
10g
Price
$56
Updated
2021/12/16
AK Scientific
Product number
D078
Product name
2-Aminomethyl-4-(4-fluorobenzyl)morpholine
Packaging
5g
Price
$57
Updated
2021/12/16
Matrix Scientific
Product number
072700
Product name
(4-(4-Fluorobenzyl)morpholin-2-yl)methanamine
Purity
95+%
Packaging
1g
Price
$59
Updated
2021/12/16
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4-[(4-Fluorophenyl)methyl]-2-morpholinemethanamine Chemical Properties,Usage,Production

Chemical Properties

Clear Pale Yellow Oil

Uses

Mosapride intermediate.

Synthesis

5455-98-1

22116-33-2

112914-13-3

General procedure for the synthesis of 2-aminomethyl-4-(4-fluorobenzyl)-morpholine from N-(2,3-epoxypropyl)phthalimide and 2-(4-fluorobenzylamino)ethanol: 2-(4-fluorobenzylamino)ethanol (28.7 g, 0.17 mol) and N-(2,3-epoxypropyl)phthalimide (35.0 g, 0.13 mol) were added to the reaction kettle. The reaction was heated to 70-80°C and held for 3 hours. Subsequently, sulfuric acid was slowly added dropwise at 70-90°C and the reaction was continued at 125-145°C for 2.5 hours. Upon completion of the reaction, the mixture was transferred to cold water, cooled to 0°C, crystallized and filtered. The filtrate was neutralized with sodium hydroxide, extracted with chloroform, dried the organic phase and concentrated to dryness to give 4-(4-fluorobenzyl)-2-aminomethylmorpholine as a light yellow oil (yield: 75.1%, purity: 80.2%).

References

[1] Patent: CN108341788, 2018, A. Location in patent: Paragraph 0074; 0075; 0076
[2] Chemical and Pharmaceutical Bulletin, 1996, vol. 44, # 8, p. 1484 - 1492
[3] Patent: CN108129414, 2018, A. Location in patent: Paragraph 0050; 0053; 0054

4-[(4-Fluorophenyl)methyl]-2-morpholinemethanamine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[(4-Fluorophenyl)methyl]-2-morpholinemethanamine Suppliers

Canada 1 China 146 Europe 2 India 4 United Kingdom 3 United States 9 Global 165
ecochem international chemical broker
Tel
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Fax
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Email
export@ecochem.dk
Country
Europe
ProdList
6371
Advantage
66
kemikalieimport
Tel
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Fax
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Email
Sales@kemikalieimport.dk
Country
Europe
ProdList
6685
Advantage
47
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View Lastest Price from 4-[(4-Fluorophenyl)methyl]-2-morpholinemethanamine manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
4-[(4-Fluorophenyl)methyl]-2-morpholinemethanamine 112914-13-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-19
Career Henan Chemical Co
Product
4-[(4-Fluorophenyl)methyl]-2-morpholinemethanamine 112914-13-3
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
Customized
Release date
2018-12-22

112914-13-3, 4-[(4-Fluorophenyl)methyl]-2-morpholinemethanamineRelated Search:

2-BROMO-3,3,3-TRIFLUOROPROPENE METHYL 4-FLUORO-2-HYDROXYBENZOATE 5-NITRO-3-BROMOINDAZOLE Mono-methyl isophthalate 6(5H)-Phenanthridone 1H-indazole-6-carboxylic acid 2-FLUORO-5-NITROPHENOL Butyl 2-methylbutyrate FEMA 2200 2,8-DICHLORO-QUINOLINE-3-CARBALDEHYDE 2-Chloro-5-fluorobenzonitrile N-PHENYLETHYLENEDIAMINE Isoquinoline, 6-chloro- (6CI,9CI) Norethindrone 4-[(4-fluorophenyl)methyl]-3-morpholinemethanamine Mosapride Mosapride citrate 4-[(4-Fluorophenyl)methyl]-2-morpholinemethanamine

  • C-[4-(4-FLUORO-BENZYL)-MORPHOLIN-2-YL]-METHYLAMINE DIHYDROCHLORIDE
  • 2-Aminoethy-4-(4-Fluorobenzyl)-morpholine
  • 2-(AminoMethyl)-4-(4-FluoroBenzyl)Morpholine,Mosapride
  • 2-Aminomethy-4-(4-fluorobenzyl)morpholine
  • 4-[(4-Fluorophenyl)methyl]-2-morpholinemethanamine
  • {4-[(4-fluorophenyl)Methyl]Morpholin-2-yl}MethanaMine
  • (4-(4-Fluorobenzyl)Morpholin-2-yl)MethanaMine
  • 2-(Aminomethyl)-4-(4-fluorobenzyl)morpholine, 1-{[2-(Aminomethyl)morpholin-4-yl]methyl}-4-fluorobenzene
  • 2-Aminomethy-4-(4-fluorobenzyl)morpholine, >=98%
  • 4-[(4-Fluorophenyl)methyl]-2-morpholinemethamine
  • 2-Morpholinemethanamine,4-[(4-fluorophenyl)methyl]-
  • [4-[(4-fluorophenyl)methyl]-2-morpholinyl]methanamine
  • 4-[(4-Fluorophenyl)methyl]-2-morpholinemethanamineQ: What is 4-[(4-Fluorophenyl)methyl]-2-morpholinemethanamine Q: What is the CAS Number of 4-[(4-Fluorophenyl)methyl]-2-morpholinemethanamine Q: What is the storage condition of 4-[(4-Fluorophenyl)methyl]-2-morpholinemethanamine Q: What are the applications of 4-[(4-Fluorophenyl)methyl]-2-morpholinemethanamine
  • (4-(4-fluorobenzyl)morpholin-2-yl)methanamine dihydrochloride
  • 2-Aminomethy-4-(4-fluorobenzvlmoroholine
  • 112914-13-3
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