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Atractylenolide-1

Product Name
Atractylenolide-1
CAS No.
73069-13-3
Chemical Name
Atractylenolide-1
Synonyms
Extracted oil;Dictyolactone I;Atracylenolide I;Atractylenolide Ⅰ;ATRACTYLENOLIDE-1;Atractylenolide I-RM;8,9-Dehydroasterolide;Atractylenolide I, >99%;Eudesma-4(15),7(11),8-trien-12-olide;Methyl 4-ethyl-6,7-dimethoxy-9H-b-carboline-3-carboxylate
CBNumber
CB5847745
Molecular Formula
C15H18O2
Formula Weight
230.3
MOL File
73069-13-3.mol
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Atractylenolide-1 Property

Melting point:
121-123 °C(Solv: ligroine (8032-32-4))
Boiling point:
405.0±44.0 °C(Predicted)
Density 
1.12
Flash point:
170℃
storage temp. 
2-8°C
solubility 
methanol: soluble1mg/mL, clear, colorless
form 
powder
color 
White
InChIKey
ZTVSGQPHMUYCRS-SWLSCSKDSA-N
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A2737
Product name
Atractylenolide I
Purity
≥98% (HPLC)
Packaging
10mg
Price
$371
Updated
2024/03/01
Sigma-Aldrich
Product number
A2737
Product name
Atractylenolide I
Purity
≥98% (HPLC)
Packaging
50mg
Price
$1080
Updated
2023/06/20
Cayman Chemical
Product number
25061
Product name
Atractylenolide I
Purity
≥98%
Packaging
5mg
Price
$141
Updated
2024/03/01
Cayman Chemical
Product number
25061
Product name
Atractylenolide I
Purity
≥98%
Packaging
10mg
Price
$267
Updated
2024/03/01
Cayman Chemical
Product number
25061
Product name
Atractylenolide I
Purity
≥98%
Packaging
25mg
Price
$455
Updated
2024/03/01
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Atractylenolide-1 Chemical Properties,Usage,Production

Description

Atractylenolide I is a sesquiterpene that has been found in the rhizomes of A. macrocephala and has diverse biological activities, including anti-inflammatory, anti-angiogenic, anti-tumor, and antidepressant properties. It inhibits LPS-induced increases in TNF-α and nitric oxide (NO) production, as well as inducible nitric oxide synthase (iNOS) activity, in murine peritoneal macrophages (IC50s = 23.1, 41, and 67.3 μM, respectively). Atractylenolide I reduces pouch fluid weight, inflammatory cell count, granuloma weight, and vascular index (ID50s = 24.18, 19.46, 14.44, and 15.15 mg/kg, respectively) in a mouse air pouch granuloma model induced by Freund''s complete adjuvant (FCA). It also reduces the number of microvessels in the air pouch wall by 58.27% when administered at a dose of 20 mg/kg and reduces the blood levels of TNF-α, IL-1β, IL-6, VEGF, placenta growth factor (PlGF), and bFGF in a dose-dependent manner in a mouse model of FCA-induced granuloma. Atractylenolide I inhibits the growth of T-24, 5637, RT4, and 253J bladder cancer cells in vitro (IC50s = 12.8-63.7 μM) and reduces tumor growth in T-24 and 253J mouse xenograft models in a dose-dependent manner. In a mouse model of depression induced by chronic unpredictable mild stress, atractylenolide I reverses stress-induced decreases in hippocampal levels of serotonin (5-HT; ) and norepinephrine and reduces immobility time in the forced swim and tail suspension tests in a dose-dependent manner, indicating antidepressant-like activity.

Atractylenolide-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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Atractylenolide-1 Suppliers

China 204 Germany 1 United Kingdom 1 United States 17 Global 223
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
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View Lastest Price from Atractylenolide-1 manufacturers

Changsha Staherb Natural Ingredients Co., Ltd.
Product
Atractylenolide-1 73069-13-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
≥98% HPLC
Supply Ability
1000kg
Release date
2022-10-18
Shaanxi Haibo Biotechnology Co., Ltd
Product
Atractylenolide I 73069-13-3
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
2000ton
Release date
2023-08-21
Shanghai Standard Technology Co., Ltd.
Product
Atractylenolide I 73069-13-3
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-11-29

73069-13-3, Atractylenolide-1Related Search:

Yellow white oil Artemisia argyi oil LITSEA CUBEBA OIL Thyme Oil Rose Oil Fennel Oil Spikenard extract Costus oil Anise oil shechuangzhiyou Daurian Rhododendron Oil Tea tree oil Cassia oil Anise Oil ATRACTYLENOLIDE Ⅲ 2-ATRACTYLENOLIDE Atractylenolide III Atractylenolide-1

  • Atractylenolide I, >99%
  • ATRACTYLENOLIDE-1
  • 3,8aβ-Dimethyl-5-methylene-2,4,4aα,5,6,7,8,8a-octahydronaphtho[2,3-b]furan-2-one
  • Eudesma-4(15),7(11),8-trien-12-olide
  • 8,9-Dehydroasterolide
  • (4aS,8aS)-4a,5,6,7,8,8a-Hexahydro-3,8a-dimethyl-5-methylenenaphtho[2,3-b]furan-2(4H)-one
  • Atractylenolide Ⅰ
  • Naphtho[2,3-b]furan-2(4H)-one,4a,5,6,7,8,8a-hexahydro-3,8a-dimethyl-5-methylene-, (4aS,8aS)-
  • Atracylenolide I
  • Extracted oil
  • Methyl 4-ethyl-6,7-dimethoxy-9H-b-carboline-3-carboxylate
  • STAT,Atractylenolide I,Janus kinase,Inhibitor,JAK,Toll-like Receptor (TLR),inhibit
  • Dictyolactone I
  • (4aS,8aS)-3,8a-Dimethyl-5-methylene-4a,5,6,7,8,8a-hexahydronaphtho[2,3-b]furan-2(4H)-one
  • Atractylenolide I-RM
  • 73069-13-3