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Heptafluorobutyric acid

Product Name
Heptafluorobutyric acid
CAS No.
375-22-4
Chemical Name
Heptafluorobutyric acid
Synonyms
HFBA;Perfluorobutanoic acid;PERFLUOROBUTYRIC ACID;2,2,3,3,4,4,4-Heptafluorobutanoic acid;PERFLUOROBUTYRATE;Perfluorobutanoicaid;heptafluorobutanoicacid;FC-23;H 0024;NSC 820
CBNumber
CB5853573
Molecular Formula
C4HF7O2
Formula Weight
214.04
MOL File
375-22-4.mol
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Heptafluorobutyric acid Property

Melting point:
-17.5 °C
Boiling point:
120 °C755 mm Hg(lit.)
Density 
1.645 g/mL at 25 °C(lit.)
vapor density 
7 (vs air)
vapor pressure 
~10 mm Hg ( 25 °C)
refractive index 
n20/D 1.3(lit.)
Flash point:
120-121°C
storage temp. 
Store below +30°C.
solubility 
Chloroform: soluble; Methanol: soluble
form 
Powder
pka
pK1:0.17 (25°C)
Specific Gravity
approximate 1.6
color 
Clear colorless to faint yellow
PH
1 (H2O, 20℃)
Water Solubility 
miscible
Sensitive 
Light Sensitive
BRN 
1426882
InChIKey
YPJUNDFVDDCYIH-UHFFFAOYSA-N
CAS DataBase Reference
375-22-4(CAS DataBase Reference)
NIST Chemistry Reference
Butanoic acid, heptafluoro-(375-22-4)
EPA Substance Registry System
Heptafluorobutyric acid (375-22-4)
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Safety

Hazard Codes 
C
Risk Statements 
34-35
Safety Statements 
26-36/37/39-45
RIDADR 
UN 3265 8/PG 2
WGK Germany 
3
RTECS 
ET4025000
F 
3-8-10
Hazard Note 
Corrosive
TSCA 
T
HazardClass 
8
PackingGroup 
II
HS Code 
29159000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.43443
Product name
Heptafluorobutyric acid
Purity
for synthesis
Packaging
5ML
Price
$43.8
Updated
2024/03/01
Sigma-Aldrich
Product number
8.43443
Product name
Heptafluorobutyric acid
Purity
for synthesis
Packaging
25ML
Price
$75.9
Updated
2024/03/01
Sigma-Aldrich
Product number
52411
Product name
Heptafluorobutyric acid
Purity
for ion chromatography, ≥99.5% (GC)
Packaging
5ml
Price
$46.6
Updated
2024/03/01
Sigma-Aldrich
Product number
52411
Product name
Heptafluorobutyric acid
Purity
for ion chromatography, ≥99.5% (GC)
Packaging
25mL
Price
$159
Updated
2024/03/01
Sigma-Aldrich
Product number
164194
Product name
Heptafluorobutyric acid
Purity
98%
Packaging
5g
Price
$31.7
Updated
2024/03/01
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Heptafluorobutyric acid Chemical Properties,Usage,Production

Chemical Properties

Clear colorless to faintly yellow liquid

Uses

Heptafluorobutyric acid is an ion pair reagent for reverse-phase HPLC. It is used in the sequencing, synthesis, and solubilizing of proteins and peptides. It is used as mobile phase modifier for enhancement of selectivity in the HPLC analysis of histone proteins. It is an effective additive for zinc electrodeposition.

Uses

Perfluorobutyric acid was used as mobile phase modifier for enhancement of selectivity in the HPLC analysis of histone proteins. It was used as ion pairing reagent in preparative and analytical reserved phase HPLC of underivatised peptides.

Uses

Heptafluorobutyric acid (HBFA) has been used widely for purifying neuropeptides because of its excellent resolution. The use of heptafluorobutyric acid as a volatile ion-pair reagent in the high-performance liquid chromatographic isolation of SB-223070 John K.
Heptafluorobutyric acid is a strong acid and ion-pairing agent that is used in analytical chemistry, notably in HPLC and in gas chromatography/mass spectrometry (GC/MS), in a similar manner to trifluoroacetic acid (TFA). The strong acidity of HFBA ensures that other acidic groups such as carboxylic acid moieties on biomolecules remain protonated, and thus the biomolecule samples are able to interact with organic solvents in such processes as reverse phase chromatography. The longer alkyl chain of HFBA makes it more hydrophobic than TFA, and thus HFBA can be utilized with more hydrophobic samples.
HFBA (0.1%) has been used in the mobile phase of an HPLC/LC-MS protocol for the detection of marine bacterioplankton sideophores.A study of the effects of various acids, including HFBA, on the resolution of intact proteins by reversed-phase LC/ESI-MS has been published.A modified version of the peptide ladder sequencing technique that incorporates allyl isothiocyanate and HFBA has been reported.

Definition

ChEBI: A monocarboxylic acid that is perfluorinated butyric acid.

General Description

Perfluorobutyric acid is an effective additive for zinc electrodeposition.

Hazard

Irritant to tissue.

Purification Methods

Fractionally distil the acid twice in an Oldershaw column (p 10) with an automatic vapour-dividing head, the first distillation being in the presence of conc H2SO4 as a drying agent. (Take care with the hot acid.) [Beilstein 2 IV 810.]

Heptafluorobutyric acid Preparation Products And Raw materials

Raw materials

Preparation Products

N-Heptafluorobutyrylimidazole Heptafluorobutyric anhydride
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Heptafluorobutyric acid Suppliers

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View Lastest Price from Heptafluorobutyric acid manufacturers

Wuhan Silworld Chemical Co.,Ltd
Product
Heptafluorobutyric acid 375-22-4
Price
US $0.00/KG
Min. Order
1KG
Purity
95% ,98%
Supply Ability
10000
Release date
2023-04-29
Career Henan Chemical Co
Product
Heptafluorobutyric acid 375-22-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200KG
Release date
2018-08-15

375-22-4, Heptafluorobutyric acidRelated Search:

Chlorambucil Butyric Acid Glycine Isobutyric acid 2,2,3,3,4,4,4-Heptafluoro-1-butanol Indole-3-butyric acid Ethyl 2-(Chlorosulfonyl)acetate 4-Aminobutyric acid CELLULOSE ACETATE BUTYRATE Hydrocortisone-17-butyrate Citric acid Folic acid Hydroxylamine-O-sulfonic acid Ascoric Acid HEPTAFLUOROBUTYRIC ACID METHYL ESTER N-BUTYL HEPTAFLUOROBUTYRATE SODIUM HEPTAFLUOROBUTYRATE HEPTAFLUOROBUTYRIC ACID, SILVER Perfluorobutanoic Acid

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