ChemicalBook > CAS DataBase List > 1,3-Propanediol

1,3-Propanediol

Product Name
1,3-Propanediol
CAS No.
504-63-2
Chemical Name
1,3-Propanediol
Synonyms
PDO;PROPANE-1,3-DIOL;1,3-PROPANDIOL;TRIMETHYLENE GLYCOL;1,3-PROPYLENE GLYCOL;PROPAN-1,3-DIOL;Dihydroxypropane;1,3-PROPANEDIOL FOR SYNTHESIS;1.3-PDO;nsc65426
CBNumber
CB5853689
Molecular Formula
C3H8O2
Formula Weight
76.09
MOL File
504-63-2.mol
More
Less

1,3-Propanediol Property

Melting point:
-27 °C (lit.)
Boiling point:
214 °C/760 mmHg (lit.)
Density 
1.053 g/mL at 25 °C (lit.)
vapor pressure 
0.8 mm Hg ( 20 °C)
refractive index 
n20/D 1.440(lit.)
FEMA 
4753 | 1,3-PROPANEDIOL
Flash point:
>230 °F
storage temp. 
Store below +30°C.
solubility 
H2O: soluble
pka
14.46±0.10(Predicted)
form 
Oily Liquid
color 
Clear
PH
4.5-7.0 (100g/l, H2O, 20℃)
explosive limit
2.5%(V)
Water Solubility 
100 g/L
Merck 
14,9714
BRN 
969155
Dielectric constant
35.0（20℃）
InChIKey
YPFDHNVEDLHUCE-UHFFFAOYSA-N
LogP
-0.71 at 20℃
CAS DataBase Reference
504-63-2(CAS DataBase Reference)
NIST Chemistry Reference
1,3-Propanediol(504-63-2)
EPA Substance Registry System
1,3-Propanediol (504-63-2)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
38
Safety Statements 
23-24/25
WGK Germany 
1
RTECS 
TY2010000
Autoignition Temperature
405 °C
TSCA 
Yes
HS Code 
29053980
Hazardous Substances Data
504-63-2(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: 15670 mg/kg LD50 dermal Rabbit > 20000 mg/kg
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

H315Causes skin irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P50404
Product name
1,3-Propanediol
Purity
98%
Packaging
100g
Price
$96.3
Updated
2025/07/31
Sigma-Aldrich
Product number
PHR3167
Product name
1,3-Propanediol
Purity
pharmaceutical secondary standard, certified reference material
Packaging
1ML
Price
$200
Updated
2025/07/31
Sigma-Aldrich
Product number
8.07481
Product name
1,3-Propanediol
Purity
for synthesis
Packaging
250ML
Price
$93.6
Updated
2025/07/31
Sigma-Aldrich
Product number
8.07481
Product name
1,3-Propanediol
Purity
for synthesis
Packaging
1L
Price
$316
Updated
2025/07/31
Sigma-Aldrich
Product number
1570483
Product name
1,3-Propanediol
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
1ml
Price
$506
Updated
2025/07/31
More
Less

1,3-Propanediol Chemical Properties,Usage,Production

Chemical Properties

1,3-Propanediol, an isomer of propylene glycol, is a viscous, colorless, odorless, hygroscopic liquid that has a brackish irritating taste. miscible with various solvents such as water, ethanol, acetone, chloroform (chloroform) and ether, and is insoluble in benzene. Combustible.

Uses

1,3-Propanediol is used as a solvent for thin film preparations, in the production of polymers such as polytrimethylene terephthalate, adhesives, laminates, coatings, moldings, aliphatic polyesters, as an antifreeze and in wood paint. It also acts as a reagent for vinyl epoxide synthon, for epoxide ring-opening, for polymerization reactions and for natural product syntheses.

Definition

ChEBI: Propane-1,3-diol is the simplest member of the class of propane-1,3-diols, consisting of propane in which one hydrogen from each methyl group is substituted by a hydroxy group. A colourless, viscous, water-miscible liquid with a high (210℃) boiling point, it is used in the synthesis of certain polymers and as a solvent and antifreeze. It has a role as a protic solvent and a metabolite.

Application

1,3-Propanediol /PDO/ is mainly used for making polytrimethylene terephthalate polymer, which is used in fibers and fabrics, for example, carpets, textiles, engineering thermoplastics, nonwovens, films, and monofilaments. PDO finds also use as chain extender in thermoplastic polyurethanes, where it contributes to improved thermal, hydrolytic and dimensional stability. In adipate polyesters with other diols these diols are partly substituted by 1,3-propanediol to break crystallinity in order to obtain liquid polyester polyols. In polyesters for powder coatings PDO improves the flexibility but lowers the glass transition temperature somewhat. PDO finds also uses in cosmetics and personal care products, engine coolants, and solvents for ink-jet and screen inks.

Biosynthesis

1,3-Propanediol (1,3-PDO) can be produced by fermentation from glycerol, with different strains such as Klebsiella pneumoniae, Clostridium butyricum, Clostridium pasteurianum, and Citrobacter freundii. Drawbacks of industrial fermentation using these strains are strong inhibition of 1,3-PDO production and by-products during fermentation.

Flammability and Explosibility

Non flammable

Synthesis

1,3-Propanediol is produced commercially by Degussa starting from acrolein.
CH2CHCHO + H2O → HOHCH2CH2CHO
HOHCH2CH2CHO + H2 → HOHCH2CH2CH2OH
The addition of water under mild acidic conditions gives 3-hydroxypropionaldehyde with high selectivity. Preferentially buffer solutions with a pH 4-5 or weak acidic ion exchange resins are used as catalysts. Further hydrogenation of this aqueous solutions gives 1,3-propanediol. There is an alternative route via hydroformylation of ethylene oxide and subsequent hydrogenation of the intermediate 3-hydroxypropionaldehyde.

Purification Methods

Dry this diol with K2CO3 and distil it under reduced pressure. More extensive purification involves conversion with benzaldehyde to 2-phenyl-1,3-dioxane (m 47-48o) which is subsequently decomposed by shaking with 0.5M HCl (3mL/g) for 15minutes and standing overnight at room temperature. After neutralisation with K2CO3, the benzaldehyde is removed by steam distillation and the diol is recovered from the remaining aqueous solution by continuous extraction with CHCl3 for 1day. The extract is dried with K2CO3, the CHCl3 is evaporated and the diol is distilled. [Foster et al. Tetrahedron 6 177 1961, Beilstein 1 IV 2493.]

1,3-Propanediol Preparation Products And Raw materials

Raw materials

Preparation Products

2-Oxetanone 1,3-Propanesultone Cyclopropylamine Fenitropane 1,3-Dichloropropane 1R-cis-Permethrinic acid (1R-cis)-3-(2,2-dibromoethenyl)-2,2-dimethylcyclopropane carboxylic acid (4S)-HYDROXY-3-METHYL-2-(2-PROPENYL)-2-CYCLOPENTENE-1-ONE 1,3-Dibromopropane 1R-trans-methyl caronaldehydate Felbamate 1R，3R-chrysanthemic acid Glutaric acid Bronopol
More
Less

1,3-Propanediol Suppliers

Americas 1 Australia 1 Belgium 4 China 530 Czech 1 Czech Republic 1 Europe 3 France 2 Germany 17 India 23 Italy 1 Japan 6 Malaysia 2 South Africa 1 South Korea 2 Switzerland 3 The Netherlands 1 Ukraine 2 United Kingdom 16 United States 60 USA 1 Global 678
Dezhou Mengxuan Chemical Co., Ltd
Tel
19163510851
Email
207451738@QQ.com
Country
China
ProdList
154
Advantage
58
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Zhejiang Invertin Biotechnology Co.,Ltd.td.
Tel
0572-2165030 17369571355
Fax
QQ:1169435659
Email
17369571355@163.com
Country
China
ProdList
58
Advantage
58
JinJin Le Chemical Co., Ltd
Tel
18001959627(微信同号) 18001959627
Email
jjlchem2@163.com
Country
China
ProdList
9981
Advantage
58
Nantong Runfeng Petrochemical Co., Ltd
Tel
0513-66017690 19952660367
Fax
0513-55085866
Email
2143087160@qq.com
Country
China
ProdList
2939
Advantage
58
Zouping Mingxing Chemical Co.,Ltd.
Tel
86-13605431940 13605431940
Fax
0086-0543-2240079
Email
zpmxchemical@126.com
Country
China
ProdList
1490
Advantage
62
Shanghai Yanze Chemical Co., Ltd.
Tel
021-021-13773155751 19975051755
Email
260924549@qq.com
Country
China
ProdList
10524
Advantage
58
Nanjing Xinzeyue Chemical Co., Ltd.
Tel
025-15298392496 15298392496
Email
1017019739@qq.com
Country
China
ProdList
40
Advantage
58
Shanghai Pearlk Chemicals Co.,Ltd.
Tel
18817334030
Email
sales@chinapearlk.com
Country
China
ProdList
13
Advantage
58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Beijing dtftchem Technology Co., Ltd.
Tel
010-60275820 13031183356
Fax
010-60270825
Email
elainezt@sina.com
Country
China
ProdList
1390
Advantage
62
Beijing HwrkChemical Technology Co., Ltd
Tel
18515581800 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
9400
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Beijing Ouhe Technology Co., Ltd
Tel
010-010-82967028 13522913783
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12000
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
16075
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18729
Advantage
57
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11705
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
7247
Advantage
62
Nanjing Vital Chemical Co., Ltd.
Tel
Please Send Email 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
4378
Advantage
65
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11707
Advantage
57
ZhengZhou HuaWen Chemical Co.Ltd
Tel
0370-2785118 17550508557
Fax
QQ：3470079902
Email
675141927@qq.com
Country
China
ProdList
3199
Advantage
55
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9658
Advantage
60
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
Advantage
55
T&W GROUP
Tel
021-61551611 13296011611
Fax
＋86 21-50676805
Email
contact@trustwe.com
Country
China
ProdList
9895
Advantage
58
Yangzhou Hopechem Co., Ltd.
Tel
15062859468
Fax
QQ:1719657062，MSN:quality.kate@hotmail.com
Country
China
ProdList
100
Advantage
58
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Beijing innoChem Science & Technology Co.,Ltd.
Tel
400-810-7969 010-59572699
Fax
010-59572688
Email
ningzi.li@inno-chem.com.cn
Country
China
ProdList
6134
Advantage
55
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19913
Advantage
55
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
150-2103-5486 18017383231
Fax
qq：2817624287
Email
983544897@qq.com
Country
China
ProdList
9342
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18209
Advantage
56
Shanghai chuqing Organosilane technology ltd
Tel
021-61530618; 18721685818
Fax
86-21-51714575
Email
sales@chuqingtech.com
Country
China
ProdList
274
Advantage
55
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9546
Advantage
55
Cantotech Chemicals, Ltd.
Tel
86-0755-86635001
Fax
86-0755-22642228
Email
cantotech@126.com
Country
China
ProdList
4566
Advantage
55
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.
Tel
+86-28-85122536 85324413
Fax
+86-28-85326443
Email
market@astatech.cn
Country
China
ProdList
8026
Advantage
55
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Shanghai BeiZhuo Biotech Co., Ltd.
Tel
021-61119791,13386096464
Fax
021-50190009
Email
bzswkf@foxmail.com
Country
China
ProdList
3921
Advantage
50
Hubei XinyuanShun Chemical Co., Ltd.
Tel
13971561712, 13995564702, 027-50664929
Fax
027-50664927
Email
hbeixys2001@163.com
Country
China
ProdList
3120
Advantage
55
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9979
Advantage
55
More
Less

View Lastest Price from 1,3-Propanediol manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
1,3-Propanediol 504-63-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98
Supply Ability
10000KGS
Release date
2025-12-03
Zouping mingyuan import & export trading co., ltd
Product
1,3-Propanediol 504-63-2
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
200 tons
Release date
2025-08-05
Shaanxi Dideu Medichem Co. Ltd
Product
1,3-Propanediol 504-63-2
Price
US $300.00-13.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20000KG
Release date
2025-04-29

504-63-2, 1,3-PropanediolRelated Search:

1-Hydroxyethylidene-1,1-diphosphonic acid Glycerol 1,4-Butanediol 3-Diethylaminophenol DI(PROPYLENE GLYCOL) BUTYL ETHER BIS-Tris Propane 2-Butoxyethanol 2-Methyl-2,4-pentanediol Butylated Hydroxytoluene Diethylene glycol Dipropylene glycol 1-Phenoxy-2-propanol 1-Methoxy-2-propanol Chrysin Ethylene glycol Triclosan 1,3-Dihydroxyacetone C8E3

  • RiceBran Ferment(Saccharomyes/Rice Bran Ferment&Aspergillu Ferment&Propanediol)
  • 1,3-PROPANEDIOL, 98%1,3-PROPANEDIOL, 98%1,3-PROPANEDIOL, 98%1,3-PROPANEDIOL, 98%
  • 1 3 -PROPANEDIOL (PROPANDIOL )
  • 1,3-Propanediol Vetec(TM) reagent grade, 98%
  • KARL FISCHER WATER STANDARD 100 Μ
  • 1,3-Propanediol, Standard for GC,>=99.5%(GC)
  • 1,3-prpanediol
  • 1,3-PROPANEDIOL FOR SYNTHESIS
  • 1,3-Propylenediol
  • 2-(Hydroxymethyl)ethanol
  • 2-Deoxyglycerol
  • beta-Propylene glycol
  • beta-propyleneglycol
  • I,3-Propandiol
  • NSC 65426
  • nsc65426
  • omega-Propanediol
  • propane diol-1,3
  • Propanediol-(1,3)-(1,3-propylene glycol)
  • 1,3-PROPYLENE GLYCOL
  • 1,3-PROPANEDIOL
  • 1,3-PROPANDIOL
  • 1,3-DIHYDROXYPROPANE
  • AKOS 90317
  • AKOS BBS-00004418
  • 1,3-Dihydroxypropane Trimethylene glycol Propane-1,3-diol
  • PDO
  • PROPANE-1,3-DIOL
  • TRIMETHYLENE GLYCOL
  • PROPAN-1,3-DIOL
  • 1,3-PROPANEDIOL 99%
  • Dihydroxypropane
  • 1,3-Propandeiol
  • 1,3-PROPANEDIOL, 99.6+%
  • 1,3-Propanediol,Certified
  • 1,3-Propenediol
  • 1,3-Propanediol,typically98%,
  • 1,3-Propanediol,99%
  • 1,3-Propanediol, min. 99,7%,
  • 1,3-Dihydroxypropane, Trimethylene glycol
  • 1,3-Propanediol,98%
  • 1,3-Propanediol,1,3-Dihydroxypropane, Trimethylene glycol
  • 1,3-Propanediol (1 mL)
  • 1,3-Propanediol, 98% 1LT
  • 1,3-Propanediol, 98% 250ML
  • 1,3-Prop1,3-Propylene Glycolylene Glycol
  • 1,3-Propanediol Standard
  • Propanediol Propanediol
  • 1,3-Propanediol&gt
  • 1,3-Propanediol, Standard for
  • CAS 504-63-2 Cosemtic Grade 1, 3 Propanediol with Best Price
  • Propanediol / 1,3-Propanediol
  • Propane-1,3-Diol, Pure, Fisher Chemical
  • 1.3-PDO
  • 1,3-Propanediol (8CI, 9CI, ACI)
  • Tirofiban Impurity 112
  • C16405300 1,3-Propanediol
  • Colesevelam Impurity 15