ChemicalBook > CAS DataBase List > AZD-5305

AZD-5305

Product Name: AZD-5305
CAS No.: 2589531-76-8
Chemical Name: AZD-5305
Synonyms: AZD-5305;saruparib;AZD5305 ，S9875;Saruparib (AZD5305);AZD5305, 10 mM in DMSO;5-[4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]-1-piperazinyl]-N-methylpicolinamide;5-(4-((7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl)piperazin-1-yl)-N-methylpicolinamide;5-{4-[(7-ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide;2-Pyridinecarboxamide, 5-[4-[(7-ethyl-5,6-dihydro-6-oxo-1,5-naphthyridin-3-yl)methyl]-1-piperazinyl]-N-methyl-;repair,AZD5305,Inhibitor,poly ADP ribose polymerase,DNA,AZD-5305,PARP,inhibit,pathway,synthetic,AZD 5305,lethality
CBNumber: CB58941287
Molecular Formula: C22H26N6O2
Formula Weight: 406.48
MOL File: 2589531-76-8.mol

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AZD-5305 Property

Boiling point:: 702.6±60.0 °C(Predicted)
Density: 1.246±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 41.67 mg/mL (102.51 mM; Need ultrasonic)
pka: 11.26±0.40(Predicted)
form: Solid
color: Off-white to light yellow
InChIKey: WQAVGRAETZEADU-UHFFFAOYSA-N
SMILES: C1(C(NC)=O)=NC=C(N2CCN(CC3=CC4=C(N=C3)C=C(CC)C(=O)N4)CC2)C=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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AZD-5305 Chemical Properties,Usage,Production

Uses

Saruparib (AZD5305) is a potent, orally active and selective PARP inhibitor and trapper with IC50 values of 3 nM and 1400 nM for PARP1 and PARP2, respectively. Saruparib has anti-proliferative activity and inhibits growth in cells with deficiencies in DNA repair[1][2].

in vivo

Saruparib (AZD5305) (0.01-0.3 mg/kg; p.o.; daily, for 35 d; female Han Wistar rats) demonstrates sustained antitumor activity in BRCAm xenograft and PDX models in vivo^[1].

Animal Model:	Female Han Wistar rats with BRCAm xenograft and PDX models (12-13 weeks of age)^[1]
Dosage:	0.01, 0.03, 0.1, and 0.3 mg/kg
Administration:	Oral administration; daily, for 35 days
Result:	Had antitumor efficacy in a dose-dependent manner.

IC 50

PARP1: 3 nM (IC₅₀); PARP2: 1400 nM (IC₅₀)

References

[1] Illuzzi G, et, al. Preclinical Characterization of AZD5305, A Next-Generation, Highly Selective PARP1 Inhibitor and Trapper. Clin Cancer Res. 2022 Nov 1;28(21):4724-4736. DOI:10.1158/1078-0432.CCR-22-0301
[2] Johannes JW, et, al. Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs. J Med Chem. 2021 Oct 14;64(19):14498-14512. DOI:10.1021/acs.jmedchem.1c01012

AZD-5305 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZD-5305 Suppliers

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2589531-76-8, AZD-5305Related Search:

AZD-5672 AZD0364 CCR1 antagonist AZD-7648 AZD5153 AZD-8055 AZD-0284 AZD 3759 2-Pyridinecarboxamide, 6-fluoro-5-[4-[(5-fluoro-3,4-dihydro-2-methyl-3-oxo-6-quinoxalinyl)methyl]-1-piperazinyl]-N-methyl- AZD3839 hemifuMarate KGZHRAVDXGQUQM-WCQGTBRESA-N (S)-1-(2-(difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine AZD-2858 AZD-0156

2-Pyridinecarboxamide, 5-[4-[(7-ethyl-5,6-dihydro-6-oxo-1,5-naphthyridin-3-yl)methyl]-1-piperazinyl]-N-methyl-

AZD-5305

5-[4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]-1-piperazinyl]-N-methylpicolinamide

repair,AZD5305,Inhibitor,poly ADP ribose polymerase,DNA,AZD-5305,PARP,inhibit,pathway,synthetic,AZD 5305,lethality

5-(4-((7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl)piperazin-1-yl)-N-methylpicolinamide

Saruparib (AZD5305)

saruparib

5-{4-[(7-ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide

AZD5305, 10 mM in DMSO

AZD5305 ，S9875

2589531-76-8

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