ChemicalBook > CAS DataBase List > 2-Methyl-1H-imidazole-4-carboxylic acid
2-Methyl-1H-imidazole-4-carboxylic acid
- Product Name
- 2-Methyl-1H-imidazole-4-carboxylic acid
- CAS No.
- 1457-58-5
- Chemical Name
- 2-Methyl-1H-imidazole-4-carboxylic acid
- Synonyms
- 2-methyl-1H-imidazole-5-carboxylic acid;2-Methyl-4-carboxyiMidazole;2-Methyl-1H-imidazole-4-car;2-Methyl-1H-imidazol-4-carbonsure;2-MethyliMidazole-4-carboxylic acid;2-Methyl-4-iMidazolecarboxylic Acid;2-methyl-1H-imidazole-5-carboxylicaci;2-Methyl-1H-imidazol-5-carboxylic acid;2-Methyl-1H-imidazol-4-carboxylic acid;2-Methyl-1H-imidazole-4-carboxylic acid
- CBNumber
- CB5905773
- Molecular Formula
- C5H6N2O2
- Formula Weight
- 126.11
- MOL File
- 1457-58-5.mol
More
Less
2-Methyl-1H-imidazole-4-carboxylic acid Property
- Boiling point:
- 475.8±18.0 °C(Predicted)
- Density
- 1.404±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 2.76±0.10(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C5H6N2O2/c1-3-6-2-4(7-3)5(8)9/h2H,1H3,(H,6,7)(H,8,9)
- InChIKey
- DTUIYOVMTFYCBZ-UHFFFAOYSA-N
- SMILES
- C1(C)NC(C(O)=O)=CN=1
More
Less
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
More
Less
N-Bromosuccinimide Price
TRC
- Product number
- M313010
- Product name
- 2-Methyl-1H-imidazole-5-carboxylicAcid
- Packaging
- 500mg
- Price
- $150
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- CHM0149672
- Product name
- 2-METHYL-1H-IMIDAZOLE-4-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $852.55
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- CHM0149672
- Product name
- 2-METHYL-1H-IMIDAZOLE-4-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $1227.82
- Updated
- 2021/12/16
AK Scientific
- Product number
- W3181
- Product name
- 2-Methyl-1H-imidazole-4-carboxylicacid
- Packaging
- 250mg
- Price
- $127
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 134953
- Product name
- 2-Methyl-1H-imidazole-4-carboxylicacid
- Purity
- 95%+
- Packaging
- 5g
- Price
- $1462
- Updated
- 2021/12/16
More
Less
2-Methyl-1H-imidazole-4-carboxylic acid Chemical Properties,Usage,Production
Uses
2-Methyl-1H-imidazole-4-carboxylic acid can be used as an intermediate for the preparation of heteroaryl oxadiazole derivative useful for the treatment of hyperproliferative and angiogenesis disorders.
Synthesis
35034-22-1
1457-58-5
General procedure for the synthesis of 2-methyl-1H-imidazole-5-carboxylic acid from 2-methyl-1H-imidazole-5-carboxaldehyde: To a solution of 2-methyl-1H-imidazole-5-carboxaldehyde (10 g, 91 mmol) in acetonitrile (ACN, 60 mL) was added sulfamic acid (11 g, 120 mmol) at 0 °C and the reaction solution was stirred for 5 min. Subsequently, 2-methyl-2-butene (13 mL, 120 mmol) was added. An aqueous solution of sodium chlorite (11 g, 120 mmol) was slowly added dropwise to the reaction mixture, and after completion of the dropwise addition, the reaction system was brought to room temperature and stirring was continued for 4 hours. After completion of the reaction, acetonitrile (MeCN) was removed by distillation under reduced pressure. The reaction was quenched with 1.5 N hydrochloric acid (HCl) and subsequently extracted with ethyl acetate (EtOAc, 250 mL x 3). The organic phases were combined, washed with brine (200 mL), dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to afford the target product 2-methyl-1H-imidazole-5-carboxylic acid (9.0 g, 71 mmol, 79% yield). The product was characterized by 1H NMR (300 MHz, DMSO-d6): δ 11.94 (brs, 1H), 9.61 (s, 1H), 7.88 (s, 1H), 1.91 (s, 3H).
References
[1] Patent: WO2014/144037, 2014, A1. Location in patent: Page/Page column 185
[2] Journal of the American Chemical Society, 2002, vol. 124, # 38, p. 11272 - 11273
2-Methyl-1H-imidazole-4-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
2-Methyl-1H-imidazole-4-carboxylic acid Suppliers
- Tel
- 22-58627059 13920586291
- Fax
- 022-58620305
- zdcomcon@126.com
- Country
- China
- ProdList
- 3829
- Advantage
- 50
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9309
- Advantage
- 66
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 16077
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 15402
- Advantage
- 60
- Tel
- +86-25-68710855, +86-25-68710897
- Fax
- 025-68710856
- sales@springpharma.net
- Country
- China
- ProdList
- 1261
- Advantage
- 62
- Tel
- 025-58395930
- Fax
- 025-5861-9182
- sales@acornpharma.com
- Country
- China
- ProdList
- 982
- Advantage
- 60
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9510
- Advantage
- 58
- Tel
- 150-2103-5486 18017383231
- Fax
- qq：2817624287
- 983544897@qq.com
- Country
- China
- ProdList
- 9342
- Advantage
- 55
- Tel
- 021-68712331 39130253
- Fax
- 18621350903
- aokchem@gmail.com
- Country
- China
- ProdList
- 332
- Advantage
- 58
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 400-8592883
- Fax
- 0731-82251112
- sales@huatengsci.com
- Country
- China
- ProdList
- 5872
- Advantage
- 58
- Tel
- 13120367189
- Fax
- 021-50315529
- mychess007@163.com
- Country
- China
- ProdList
- 1994
- Advantage
- 55
- Tel
- 021-61478794
- Fax
- 021-61478794
- sales@hcshhai.com
- Country
- China
- ProdList
- 9793
- Advantage
- 50
- Tel
- +86-0579-86846643 18072368515
- Fax
- +86-0579-86846643
- sales@honsentech.com.cn
- Country
- China
- ProdList
- 124
- Advantage
- 55
- Tel
- 021-60455363 18019463053
- Fax
- 50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 12346
- Advantage
- 58
- Tel
- 86-(0)21-31261262 373522135
- Fax
- 86-(0)21-33250524
- sales@novochemy.com
- Country
- China
- ProdList
- 6498
- Advantage
- 58
- Tel
- 0431-0431-80514535 19917294565
- et@chemextension.com
- Country
- China
- ProdList
- 3935
- Advantage
- 55
- Tel
- 18114022054; 18114022054
- Fax
- +86-25-58857385
- 3317707757@qq.com
- Country
- China
- ProdList
- 301
- Advantage
- 55
- Tel
- 027-65388397 18164111589
- Fax
- 027-65388397
- 3321478047@qq.com
- Country
- China
- ProdList
- 2007
- Advantage
- 55
- Tel
- 025-83453382-8005
- Fax
- 025-83453382
- sale@parabiochem.com
- Country
- China
- ProdList
- 9595
- Advantage
- 55
- Tel
- 0371-0371-55629727 13323845623
- Fax
- 037155629727
- 2885676761@qq.com
- Country
- China
- ProdList
- 10109
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 微信 17321281695 18019252918
- Fax
- 021-31261685
- sale@amkchem.com
- Country
- China
- ProdList
- 9519
- Advantage
- 55
- Tel
- 0371-55900031 18137872243
- Fax
- QQ：2853979815
- 2853979815@qq.com
- Country
- China
- ProdList
- 9984
- Advantage
- 55
- Tel
- 13761310616
- Fax
- QQ: 39324283
- 39324283@qq.com
- Country
- China
- ProdList
- 1628
- Advantage
- 58
- Tel
- 13127280945
- 285424065@qq.com
- Country
- China
- ProdList
- 9976
- Advantage
- 55
- Tel
- 0371-65829290
- Fax
- 0371-65829290
- 2602793954@qq.com
- Country
- China
- ProdList
- 41
- Advantage
- 58
- Tel
- 86-0573-85866609 13325730825
- Fax
- 0573-85866609
- 945717149@qq.com
- Country
- China
- ProdList
- 8595
- Advantage
- 58
- Tel
- 025-58859352 18068836627
- Fax
- (5)02557626880
- dt3@aikonchem.com
- Country
- China
- ProdList
- 15493
- Advantage
- 58
- Tel
- 021-61469567 13482353728
- Fax
- 021-61161605
- sales@fdc-chemical.com
- Country
- China
- ProdList
- 9734
- Advantage
- 58
- Tel
- 400-8210725 400821072
- Fax
- 021-58955996
- malulu@leyan.com
- Country
- China
- ProdList
- 25000
- Advantage
- 58
- Tel
- 4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52687
- Advantage
- 58
- Tel
- 021-50822001
- marketing@medicilon.com.cn
- Country
- China
- ProdList
- 1152
- Advantage
- 58
- Tel
- 15995785122
- 3003020078@qq.com
- Country
- China
- ProdList
- 1198
- Advantage
- 58
- Tel
- +86-400-002-6226 +86-13028896684;
- sales@rrkchem.com
- Country
- China
- ProdList
- 57422
- Advantage
- 58
- Tel
- 010-010-50927516 15646540276
- 2420081476@qq.com
- Country
- China
- ProdList
- 81
- Advantage
- 58
- Tel
- 021-50676523 18019098996
- info@acelybio.com
- Country
- China
- ProdList
- 3960
- Advantage
- 58
- Tel
- +86-27-50766799 +8618062016861
- contact@labnetwork.com
- Country
- China
- ProdList
- 19987
- Advantage
- 58
- Tel
- +8613367258412
- Fax
- 18062427325
- ada@ipurechemical.com
- Country
- China
- ProdList
- 10237
- Advantage
- 58
- Tel
- +8615986615575
- Fax
- 0086-13651442114
- info@codchem.com
- Country
- China
- ProdList
- 20342
- Advantage
- 58
- Tel
- 86-21-51086038
- Fax
- 86-21-51861608
- chemwill_asia@126.com
- Country
- CHINA
- ProdList
- 23912
- Advantage
- 58
- Tel
- 0371-63357898
- Fax
- 1280786222
- 1280786222@qq.com
- Country
- China
- ProdList
- 3712
- Advantage
- 58
- Tel
- 037188900765 18037465274
- Fax
- QQ3430974218
- enyawanglei@sina.cn
- Country
- China
- ProdList
- 13966
- Advantage
- 58
- Tel
- +86-023-6139-8061 +86-86-13650506873
- sales@chemdad.com
- Country
- China
- ProdList
- 39927
- Advantage
- 58
- Tel
- +8618523575427
- sales@conier.com
- Country
- China
- ProdList
- 49975
- Advantage
- 58
- Tel
- 021-58461859 15821823057
- service@aiviche.com
- Country
- China
- ProdList
- 49312
- Advantage
- 58
- Tel
- 18584079237
- 312074905@qq.com
- Country
- China
- ProdList
- 2513
- Advantage
- 58
More
Less
View Lastest Price from 2-Methyl-1H-imidazole-4-carboxylic acid manufacturers
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- 2-Methyl-1H-imidazole-4-carboxylic acid 1457-58-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
Career Henan Chemical Co
- Product
- 2-Methyl-1H-imidazole-4-carboxylic acid 1457-58-5
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- customise
- Release date
- 2018-08-09
1457-58-5, 2-Methyl-1H-imidazole-4-carboxylic acidRelated Search:
1-Methylimidazole
2-Methylimidazole
Imidazole
Methyl salicylate
1H-Imidazole-4-carboxylic acid
METSULFURON METHYL
p-Toluic acid
Tribenuron methyl
Kresoxim-methyl
o-Toluic acid
4-(Chloromethyl)benzoic acid
Thiophanate-methyl
Methyl
Methyl bromide
ETHYL 2,7-DIMETHYLIMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLATE
2-METHYL-IMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER
1-METHYL-1H-IMIDAZOLE-4-CARBOXYLIC ACID
ETHYL 7-METHYL-2-PHENYLIMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLATE