ChemicalBook > CAS DataBase List > 2-(6-Aminopurin-9-yl)ethanol

2-(6-Aminopurin-9-yl)ethanol

Product Name
2-(6-Aminopurin-9-yl)ethanol
CAS No.
707-99-3
Chemical Name
2-(6-Aminopurin-9-yl)ethanol
Synonyms
Adefovir Impurity 5 CRS;6-AMINO-9H-PURIN-9-ETHANOL;9-(2-hydroxyethyl) adenine;Tenofovir Ethanol Impurity;9-(2-Hydroxyethyl)adenine>2-(6-AMINOPURIN-9-YL)ETHANOL;9H-Purine-9-ethanol, 6-amino-;2-(6-azanylpurin-9-yl)ethanol;Tenofovirdisoproxil Impurity 39;6-Amino-9-(2-hydroxyethyl)purine
CBNumber
CB5947254
Molecular Formula
C7H9N5O
Formula Weight
179.18
MOL File
707-99-3.mol
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2-(6-Aminopurin-9-yl)ethanol Property

Melting point:
240.0 to 244.0 °C
Boiling point:
473.2±55.0 °C(Predicted)
Density 
1.67±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO (Slightly, Sonicated), Methanol (Slightly, Sonicated)
pka
14.35±0.10(Predicted)
form 
Solid
color 
White to Off-White
Water Solubility 
10g/L at 20℃
λmax
261nm(H2O)(lit.)
InChIKey
VAQOTZQDXZDBJK-UHFFFAOYSA-N
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Safety

HS Code 
2933.99.8290
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
H1290
Product name
9-(2-Hydroxyethyl)adenine
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$56
Updated
2025/07/31
TCI Chemical
Product number
H1290
Product name
9-(2-Hydroxyethyl)adenine
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$212
Updated
2025/07/31
TRC
Product number
A628908
Product name
2-(6-Aminopurin-9-yl)ethanol
Packaging
50mg
Price
$50
Updated
2021/12/16
TRC
Product number
A628908
Product name
2-(6-Aminopurin-9-yl)ethanol
Packaging
100mg
Price
$70
Updated
2021/12/16
AK Scientific
Product number
J57185
Product name
9-(2-Hydroxyethyl)adenine
Packaging
1g
Price
$15
Updated
2021/12/16
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2-(6-Aminopurin-9-yl)ethanol Chemical Properties,Usage,Production

Uses

2-(6-Aminopurin-9-yl)ethanol is a useful intermediate in the preparation of aryloxyalkyl derivatives of adenine with antiviral activity.

Synthesis

96-49-1

66224-66-6

707-99-3

Example 5 Preparation of 9-(2-hydroxyethyl)adenine (5) A mechanical stirrer, condenser tube, thermometer and heating jacket were assembled on a 12L three-necked round bottom flask. After the system was replaced by nitrogen, adenine (504 g), vinyl carbonate (343 g), N,N-dimethylformamide (DMF, 3.7 L) and sodium hydroxide (7.80 g) were added sequentially. Stirring was turned on and the mixture was heated to reflux (about 80 min to reach reflux, reactor internal temperature 145°C) and the reflux reaction was maintained for 2 hours. The heating jacket was removed and the yellow reaction solution was allowed to cool naturally to below 100°C. The mixture was then cooled to 5 °C in an ice bath and diluted with the addition of toluene (3.8 L). The temperature of the reaction system was kept below 10 °C and the stirring was continued for 2 hours and then filtered. The filter cake was washed sequentially with toluene (2 x 0.5 L) and pre-cooled ethanol (1.5 L), and finally dried under reduced pressure conditions (-30 inches Hg) at 50 °C for 14 h to constant weight. The resulting product 5 was characterized for purity and structure by HPLC and 1H-NMR (DMSO-d6).

References

[1] Patent: CN106699814, 2017, A. Location in patent: Paragraph 0020-0021
[2] Molecules, 2012, vol. 17, # 11, p. 13290 - 13306
[3] Patent: US2003/225277, 2003, A1. Location in patent: Page 10-11
[4] Tetrahedron Letters, 2006, vol. 47, # 11, p. 1767 - 1770
[5] Patent: CN104387421, 2016, B. Location in patent: Paragraph 0026-0028

2-(6-Aminopurin-9-yl)ethanol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-(6-Aminopurin-9-yl)ethanol manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Tenofovir impurity 39 707-99-3
Price
US $0.00/mg
Min. Order
10mg
Purity
0.98
Supply Ability
5g
Release date
2025-02-13
Xinxiang Hongqi District Houyuan Trading Co.,Ltd
Product
2-(6-Aminopurin-9-yl)ethanol 707-99-3
Price
US $30.00-28.00/Kg
Min. Order
1Kg
Purity
99.0% up
Supply Ability
50 tons per month
Release date
2022-10-21
Career Henan Chemical Co
Product
2-(6-Aminopurin-9-yl)ethanol 707-99-3
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1000KG
Release date
2019-09-04

707-99-3, 2-(6-Aminopurin-9-yl)ethanolRelated Search:

Methyl 2-hydroxyethyl cellulose 2-Hydroxyethanesulphonic acid Ethyl acetate Hydroxyethyl starch Hydroxyethyl Cellulose Sodium isethionate 3-METHYLADENINE 2-Methoxyethanol 6-Benzylaminopurine 2-(2-Aminoethylamino)ethanol Ethanol Diethanolamine Adenine rac-Tenofovir-d7 Chloromethyl isopropyl carbonate ChloroMethyl Propyl Carbonate (S)-Tenofovir 2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[(1R)-2-[6-[[[[9-[(2R)-5-hydroxy-2,11-diMethyl-5-oxido-9-oxo-3,6,8,10-tetraoxa-5-phosphadodec-1-yl]-9H-purin-6-yl]aMino]Methyl]aMino]-9H-purin-9-yl]-1-Methylethoxy]Methyl]-, 1,9-bis(1-Methylethyl) ester, 5-ox

  • 6-Amino-9-(2-hydroxyethyl)-9H-purine
  • 2-(6-azanylpurin-9-yl)ethanol
  • 2-(6-aMino-9H-purin-9-yl)ethan-1-ol
  • 6-Amino-9-(2-hydroxyethyl)purine
  • 9-(2-hydroxyethyl) adenine
  • 6-AMINO-9H-PURIN-9-ETHANOL
  • 2-(6-AMINOPURIN-9-YL)ETHANOL
  • Tenofovirdisoproxil Impurity 39
  • Tenofovir Ethanol Impurity
  • 9-(2-Hydroxyethyl)adenine&gt
  • 9H-Purine-9-ethanol, 6-amino-
  • phenyl hydrogen ((((R)-1-((9H-purin-6-yl)amino)propan-2-yl)oxy)methyl)phosphonate
  • Adefovir Impurity 5 CRS
  • Tenofovir disoproxil Impurity 80
  • 707-99-3