2-(6-Aminopurin-9-yl)ethanol

Product Name: 2-(6-Aminopurin-9-yl)ethanol
CAS No.: 707-99-3
Chemical Name: 2-(6-Aminopurin-9-yl)ethanol
Synonyms: Adefovir Impurity 5 CRS;6-AMINO-9H-PURIN-9-ETHANOL;9-(2-hydroxyethyl) adenine;Tenofovir Ethanol Impurity;9-(2-Hydroxyethyl)adenine>2-(6-AMINOPURIN-9-YL)ETHANOL;9H-Purine-9-ethanol, 6-amino-;2-(6-azanylpurin-9-yl)ethanol;Tenofovirdisoproxil Impurity 39;6-Amino-9-(2-hydroxyethyl)purine
CBNumber: CB5947254
Molecular Formula: C7H9N5O
Formula Weight: 179.18
MOL File: 707-99-3.mol

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2-(6-Aminopurin-9-yl)ethanol Property

Melting point:: 240.0 to 244.0 °C
Boiling point:: 473.2±55.0 °C(Predicted)
Density: 1.67±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO (Slightly, Sonicated), Methanol (Slightly, Sonicated)
pka: 14.35±0.10(Predicted)
form: Solid
color: White to Off-White
Water Solubility: 10g/L at 20℃
λmax: 261nm(H2O)(lit.)
InChIKey: VAQOTZQDXZDBJK-UHFFFAOYSA-N

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Safety

HS Code: 2933.99.8290

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: H1290
Product name: 9-(2-Hydroxyethyl)adenine
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $56
Updated: 2025/07/31

TCI Chemical

Product number: H1290
Product name: 9-(2-Hydroxyethyl)adenine
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $212
Updated: 2025/07/31

TRC

Product number: A628908
Product name: 2-(6-Aminopurin-9-yl)ethanol
Packaging: 50mg
Price: $50
Updated: 2021/12/16

TRC

Product number: A628908
Product name: 2-(6-Aminopurin-9-yl)ethanol
Packaging: 100mg
Price: $70
Updated: 2021/12/16

AK Scientific

Product number: J57185
Product name: 9-(2-Hydroxyethyl)adenine
Packaging: 1g
Price: $15
Updated: 2021/12/16

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2-(6-Aminopurin-9-yl)ethanol Chemical Properties,Usage,Production

Uses

2-(6-Aminopurin-9-yl)ethanol is a useful intermediate in the preparation of aryloxyalkyl derivatives of adenine with antiviral activity.

Synthesis

96-49-1

66224-66-6

707-99-3

Example 5 Preparation of 9-(2-hydroxyethyl)adenine (5) A mechanical stirrer, condenser tube, thermometer and heating jacket were assembled on a 12L three-necked round bottom flask. After the system was replaced by nitrogen, adenine (504 g), vinyl carbonate (343 g), N,N-dimethylformamide (DMF, 3.7 L) and sodium hydroxide (7.80 g) were added sequentially. Stirring was turned on and the mixture was heated to reflux (about 80 min to reach reflux, reactor internal temperature 145°C) and the reflux reaction was maintained for 2 hours. The heating jacket was removed and the yellow reaction solution was allowed to cool naturally to below 100°C. The mixture was then cooled to 5 °C in an ice bath and diluted with the addition of toluene (3.8 L). The temperature of the reaction system was kept below 10 °C and the stirring was continued for 2 hours and then filtered. The filter cake was washed sequentially with toluene (2 x 0.5 L) and pre-cooled ethanol (1.5 L), and finally dried under reduced pressure conditions (-30 inches Hg) at 50 °C for 14 h to constant weight. The resulting product 5 was characterized for purity and structure by HPLC and 1H-NMR (DMSO-d6).

References

[1] Patent: CN106699814, 2017, A. Location in patent: Paragraph 0020-0021
[2] Molecules, 2012, vol. 17, # 11, p. 13290 - 13306
[3] Patent: US2003/225277, 2003, A1. Location in patent: Page 10-11
[4] Tetrahedron Letters, 2006, vol. 47, # 11, p. 1767 - 1770
[5] Patent: CN104387421, 2016, B. Location in patent: Paragraph 0026-0028

2-(6-Aminopurin-9-yl)ethanol Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(6-Aminopurin-9-yl)ethanol Suppliers

Americas 1 China 129 Europe 1 Germany 1 India 3 Japan 1 Switzerland 1 United Kingdom 1 United States 9 Global 147

INTATRADE GmbH

Tel: +49 3493/605464
Fax: +49 3493/605470
Email: sales@intatrade.de
Country: Germany
ProdList: 3572
Advantage: 66

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View Lastest Price from 2-(6-Aminopurin-9-yl)ethanol manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Tenofovir impurity 39 707-99-3
Price: US $0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 5g
Release date: 2025-02-13

Xinxiang Hongqi District Houyuan Trading Co.,Ltd

Product: 2-(6-Aminopurin-9-yl)ethanol 707-99-3
Price: US $30.00-28.00/Kg
Min. Order: 1Kg
Purity: 99.0% up
Supply Ability: 50 tons per month
Release date: 2022-10-21

Career Henan Chemical Co

Product: 2-(6-Aminopurin-9-yl)ethanol 707-99-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1000KG
Release date: 2019-09-04

707-99-3, 2-(6-Aminopurin-9-yl)ethanolRelated Search:

Methyl 2-hydroxyethyl cellulose 2-Hydroxyethanesulphonic acid Ethyl acetate Hydroxyethyl starch Hydroxyethyl Cellulose Sodium isethionate 3-METHYLADENINE 2-Methoxyethanol 6-Benzylaminopurine 2-(2-Aminoethylamino)ethanol Ethanol Diethanolamine Adenine rac-Tenofovir-d7 Chloromethyl isopropyl carbonate ChloroMethyl Propyl Carbonate (S)-Tenofovir 2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[(1R)-2-[6-[[[[9-[(2R)-5-hydroxy-2,11-diMethyl-5-oxido-9-oxo-3,6,8,10-tetraoxa-5-phosphadodec-1-yl]-9H-purin-6-yl]aMino]Methyl]aMino]-9H-purin-9-yl]-1-Methylethoxy]Methyl]-, 1,9-bis(1-Methylethyl) ester, 5-ox

6-Amino-9-(2-hydroxyethyl)-9H-purine

2-(6-azanylpurin-9-yl)ethanol

2-(6-aMino-9H-purin-9-yl)ethan-1-ol

6-Amino-9-(2-hydroxyethyl)purine

9-(2-hydroxyethyl) adenine

6-AMINO-9H-PURIN-9-ETHANOL

2-(6-AMINOPURIN-9-YL)ETHANOL

Tenofovirdisoproxil Impurity 39

Tenofovir Ethanol Impurity

9-(2-Hydroxyethyl)adenine&gt

9H-Purine-9-ethanol, 6-amino-

phenyl hydrogen ((((R)-1-((9H-purin-6-yl)amino)propan-2-yl)oxy)methyl)phosphonate

Adefovir Impurity 5 CRS

Tenofovir disoproxil Impurity 80

707-99-3