Boc-o-methyl-D-serine

Product Name: Boc-o-methyl-D-serine
CAS No.: 86123-95-7
Chemical Name: Boc-o-methyl-D-serine
Synonyms: Boc-D-Ser(Me)-OH;BOC-O-METHYL-D-SERINE;Boc-N-D-O-methylserine;N-Boc-(D)-O-Methylserine;Boc-O-Methyl-D-serine 97%;N-Boc-O-Methyl-D-serine, 98%;(R)-N-Boc-2-aMino-3-Methoxypropionic acid;N-(tert-butoxycarbonyl)-O-methyl-D-serine;D-Serine, N-[(1,1-diMethylethoxy)carbonyl]-O-Methyl-;2-(tert-butoxycarbonylamino)-3-methoxypropanoic acid
CBNumber: CB61054969
Molecular Formula: C9H17NO5
Formula Weight: 219.24
MOL File: 86123-95-7.mol

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Boc-o-methyl-D-serine Property

Boiling point:: 355.8±37.0 °C(Predicted)
Density: 1.148±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 3.52±0.10(Predicted)
Appearance: White to light yellow Solid
optical activity: Consistent with structure
InChI: InChI=1S/C9H17NO5/c1-9(2,3)15-8(13)10-6(5-14-4)7(11)12/h6H,5H2,1-4H3,(H,10,13)(H,11,12)/t6-/m1/s1
InChIKey: RFGMSGRWQUMJIR-ZCFIWIBFSA-N
SMILES: C(O)(=O)[C@@H](COC)NC(OC(C)(C)C)=O

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Safety

HS Code: 2924190090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B667905
Product name: Boc-O-methyl-D-serine
Packaging: 50mg
Price: $60
Updated: 2021/12/16

Activate Scientific

Product number: AS26767
Product name: Boc-O-methyl-D-serine
Purity: 97+%
Packaging: 5G
Price: $67
Updated: 2021/12/16

AK Scientific

Product number: X4725
Product name: Boc-O-Methyl-D-serine
Packaging: 1g
Price: $78
Updated: 2021/12/16

Apolloscientific

Product number: OR52578
Product name: Boc-O-Methyl-D-serine
Purity: 97%
Packaging: 10g
Price: $96
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4158-1-R7
Product name: Boc-O-Methyl-D-serine
Packaging: 10g
Price: $106
Updated: 2021/12/16

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Boc-o-methyl-D-serine Chemical Properties,Usage,Production

Uses

Boc-O-methyl-D-serine is used in preparation of acylamino acid heterocyclyl amides and deuterated derivatives for the treatment of BAF complex-related disorders.

Synthesis

3262-72-4

77-78-1

86123-95-7

The general procedure for the synthesis of (R)-2-tert-butoxycarbonylamino-3-methoxypropionic acid from BOC-L-serine and dimethyl sulfate was as follows: N-Boc-L-serine (22 g, 0.107 mol) was dissolved in anhydrous tetrahydrofuran (352 ml), the solution was cooled down to 0°C and the reaction mixture was stirred for 9 hours at 0-5°C. Upon completion of the reaction, the reaction was quenched by the addition of water (110 ml) and the pH was adjusted to 10-13 with 30% sodium hydroxide solution (3 ml). subsequently, the tetrahydrofuran/hexane mixture was removed by vacuum evaporation. The residue was washed with toluene (44 ml) and then acidified with 50% citric acid solution to pH < 3.5. The acidified aqueous phase was extracted with dichloromethane (2 x 91 ml, 1 x 66 ml) and the combined dichloromethane extracts were dried by azeotropic distillation. Eventually, evaporation of the solvent gave 23.7 g of product in 100% yield. The product was analyzed by HPLC showing 90.0% purity and 100% chiral purity.

References

[1] Patent: WO2006/37574, 2006, A1. Location in patent: Page/Page column 17
[2] Patent: WO2006/37574, 2006, A1. Location in patent: Page/Page column 17-18
[3] Patent: CN104030943, 2016, B. Location in patent: Paragraph 0103; 0104
[4] Patent: WO2012/51551, 2012, A1. Location in patent: Page/Page column 36-37
[5] Tetrahedron, 2010, vol. 66, # 29, p. 5384 - 5395

Boc-o-methyl-D-serine Preparation Products And Raw materials

Raw materials

Preparation Products

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Boc-o-methyl-D-serine Suppliers

China 182 Europe 1 India 8 United Kingdom 2 United States 10 Global 203

Sichuan jiayinglai technology CO.,LTD

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Chengdu Dorher Pharmaceutical CO.,Ltd

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Changzhou Huanling Chemical Co., Ltd.

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SiChuang NanBu Honesty Technology Co., Ltd.

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J & K SCIENTIFIC LTD.

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ChemFuture PharmaTech (Jiangsu) Ltd

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Chembest Research Laboratories Limited

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Alfa Aesar

Tel: 400-6106006
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View Lastest Price from Boc-o-methyl-D-serine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Boc-D-Ser(Me)-OH 86123-95-7
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 1000kg
Release date: 2021-08-28

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-D-ser(me)-OH 86123-95-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2023-09-27

Henan Fengda Chemical Co., Ltd

Product: Boc-o-methyl-D-serine 86123-95-7
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-03-22

86123-95-7, Boc-o-methyl-D-serineRelated Search:

BOC-D-TYR(BZL)-OH Boc-D-Serine Boc-O-Benzyl-D-threoninol Boc-o-methyl-D-serine DIMETHYL (BOC-AMINO)MALONATE N-BOC-O-Benzyl-L-serine DIETHYL (BOC-AMINO)MALONATE 4-Boc-3(R)-morpholinecarboxylic acid N-(tert-Butoxycarbonyl)-O-benzyl-D-threonine BOC-D-SER(BZL)-OSU METHYL (R)-(+)-3-(TERT-BUTOXYCARBONYL)-2,2-DIMETHYL-4-OXAZOLIDINECARBOXYLATE (R)-2,2-DIMETHYL-OXAZOLIDINE-3,4-DICARBOXYLIC ACID 3-TERT-BUTYL ESTER BOC-(2R,3R)-2-AMINO-3-ETHOXYBUTANOIC ACID 4-Methyl 2-Tert-Butyloxazolidine-3,4-Dicarboxylate Boc-D-Ser(tBu)-OH BOC-D-THR(TBU)-OH BOC-(2R,3R)-2-AMINO-3-METHYLOXYBUTANOIC ACID BOC-D-MESER(ME)-OH

BOC-O-METHYL-D-SERINE

D-Serine, N-[(1,1-dimethylethoxy)carbonyl]-O-methyl- (9CI)

Boc-O-Methyl-D-serine 97%

(2R)-2-{[(tert-butoxy)carbonyl]amino}-3-methoxypropanoic acid

(R)-N-Boc-2-aMino-3-Methoxypropionic acid

2-(tert-butoxycarbonylamino)-3-methoxypropanoic acid

N-Boc-(D)-O-Methylserine

O-Methyl-N-{[(2-Methyl-2-propanyl)oxy]carbonyl}-D-serine

Boc-D-Ser(Me)-OH

D-Serine, N-[(1,1-diMethylethoxy)carbonyl]-O-Methyl-

N-Boc-O-Methyl-D-serine, 98%

Boc-N-D-O-methylserine

(R)-2-(tert-Butoxycarbonylamino)-3-methoxypropionic acid

N-(tert-butoxycarbonyl)-O-methyl-D-serine

86123-95-7

Pharmaceuticalintermediates

API

N-BOC