ChemicalBook > CAS DataBase List > Boc-o-methyl-D-serine

Boc-o-methyl-D-serine

Product Name
Boc-o-methyl-D-serine
CAS No.
86123-95-7
Chemical Name
Boc-o-methyl-D-serine
Synonyms
Boc-D-Ser(Me)-OH;BOC-O-METHYL-D-SERINE;Boc-N-D-O-methylserine;N-Boc-(D)-O-Methylserine;Boc-O-Methyl-D-serine 97%;N-Boc-O-Methyl-D-serine, 98%;(R)-N-Boc-2-aMino-3-Methoxypropionic acid;N-(tert-butoxycarbonyl)-O-methyl-D-serine;D-Serine, N-[(1,1-diMethylethoxy)carbonyl]-O-Methyl-;2-(tert-butoxycarbonylamino)-3-methoxypropanoic acid
CBNumber
CB61054969
Molecular Formula
C9H17NO5
Formula Weight
219.24
MOL File
86123-95-7.mol
More
Less

Boc-o-methyl-D-serine Property

Boiling point:
355.8±37.0 °C(Predicted)
Density 
1.148±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
3.52±0.10(Predicted)
Appearance
White to light yellow Solid
optical activity
Consistent with structure
InChI
InChI=1S/C9H17NO5/c1-9(2,3)15-8(13)10-6(5-14-4)7(11)12/h6H,5H2,1-4H3,(H,10,13)(H,11,12)/t6-/m1/s1
InChIKey
RFGMSGRWQUMJIR-ZCFIWIBFSA-N
SMILES
C(O)(=O)[C@@H](COC)NC(OC(C)(C)C)=O
More
Less

Safety

HS Code 
2924190090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TRC
Product number
B667905
Product name
Boc-O-methyl-D-serine
Packaging
50mg
Price
$60
Updated
2021/12/16
Activate Scientific
Product number
AS26767
Product name
Boc-O-methyl-D-serine
Purity
97+%
Packaging
1g
Price
$23
Updated
2021/12/16
ChemScene
Product number
CS-D0906
Product name
D-Serine,N-[(1,1-dimethylethoxy)carbonyl]-O-methyl-
Packaging
10g
Price
$59
Updated
2021/12/16
Activate Scientific
Product number
AS26767
Product name
Boc-O-methyl-D-serine
Purity
97+%
Packaging
5G
Price
$67
Updated
2021/12/16
AK Scientific
Product number
X4725
Product name
Boc-O-Methyl-D-serine
Packaging
1g
Price
$78
Updated
2021/12/16
More
Less

Boc-o-methyl-D-serine Chemical Properties,Usage,Production

Uses

Boc-O-methyl-D-serine is used in preparation of acylamino acid heterocyclyl amides and deuterated derivatives for the treatment of BAF complex-related disorders.

Synthesis

3262-72-4

77-78-1

86123-95-7

The general procedure for the synthesis of (R)-2-tert-butoxycarbonylamino-3-methoxypropionic acid from BOC-L-serine and dimethyl sulfate was as follows: N-Boc-L-serine (22 g, 0.107 mol) was dissolved in anhydrous tetrahydrofuran (352 ml), the solution was cooled down to 0°C and the reaction mixture was stirred for 9 hours at 0-5°C. Upon completion of the reaction, the reaction was quenched by the addition of water (110 ml) and the pH was adjusted to 10-13 with 30% sodium hydroxide solution (3 ml). subsequently, the tetrahydrofuran/hexane mixture was removed by vacuum evaporation. The residue was washed with toluene (44 ml) and then acidified with 50% citric acid solution to pH < 3.5. The acidified aqueous phase was extracted with dichloromethane (2 x 91 ml, 1 x 66 ml) and the combined dichloromethane extracts were dried by azeotropic distillation. Eventually, evaporation of the solvent gave 23.7 g of product in 100% yield. The product was analyzed by HPLC showing 90.0% purity and 100% chiral purity.

References

[1] Patent: WO2006/37574, 2006, A1. Location in patent: Page/Page column 17
[2] Patent: WO2006/37574, 2006, A1. Location in patent: Page/Page column 17-18
[3] Patent: CN104030943, 2016, B. Location in patent: Paragraph 0103; 0104
[4] Patent: WO2012/51551, 2012, A1. Location in patent: Page/Page column 36-37
[5] Tetrahedron, 2010, vol. 66, # 29, p. 5384 - 5395

Boc-o-methyl-D-serine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Boc-o-methyl-D-serine Suppliers

China 181 Europe 1 India 8 United Kingdom 2 United States 10 Global 202
Sichuan jiayinglai technology CO.,LTD
Tel
028-028-88457210 18190964009
Fax
QQ3213375147
Email
3054240163@qq.com
Country
China
ProdList
2293
Advantage
55
Chengdu Novel Biomedical Co., Ltd.
Tel
028-85255396 18302801538
Fax
028-85255396
Email
cdnovell@163.com
Country
China
ProdList
2390
Advantage
58
Chengdu Dorher Pharmaceutical CO.,Ltd
Tel
028-64259743; 19983537320
Email
bd-focus@focuspharm.com
Country
China
ProdList
682
Advantage
58
Changzhou Huanling Chemical Co., Ltd.
Tel
0519-89803565 13776850645
Fax
0519-89803575
Email
info4@huanlingchem.com
Country
China
ProdList
891
Advantage
68
Chengdu Chuangkecheng Biological Technology Co., Ltd.
Tel
028-028-0000000 13008177686
Fax
15928581901
Email
sales@ckcbiotech.com
Country
China
ProdList
904
Advantage
55
SiChuang NanBu Honesty Technology Co., Ltd.
Tel
0838-5675166 15883665058
Fax
0838-5675535
Email
nbcxkj@126.com
Country
China
ProdList
919
Advantage
55
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
ChemFuture PharmaTech (Jiangsu) Ltd
Tel
5108538618
Fax
86 510 85386988-8017
Email
suger.wang@chemfuture.com
Country
China
ProdList
832
Advantage
65
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
Advantage
61
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9310
Advantage
66
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14101
Advantage
59
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9883
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
shanghai Rainbow MediTech.Co.Ltd.
Tel
021-64968085,64968086-5815,5812; 13472757003
Fax
+86 21 64968087
Email
xiaoxia.zeng@rainbowpharma.cn
Country
China
ProdList
961
Advantage
65
T&W GROUP
Tel
021-61551611 13296011611
Fax
＋86 21-50676805
Email
contact@trustwe.com
Country
China
ProdList
9895
Advantage
58
Bsisun HK Imoprt And Export Company Limited
Tel
+86-18068513926
Fax
0086-519-85153711
Country
China
ProdList
1277
Advantage
55
Cantotech Chemicals, Ltd.
Tel
86-0755-86635001
Fax
86-0755-22642228
Email
cantotech@126.com
Country
China
ProdList
4566
Advantage
55
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7865
Advantage
55
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4720
Advantage
55
Beijing Universal Century Technology Co., Ltd.
Tel
400-8706899
Fax
400-8706899
Email
hysj_bj.com
Country
China
ProdList
3583
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Zhengzhou ALFA Chemical Co., Ltd.
Tel
0371-53732842 15981811963
Fax
0371-86239377
Email
1758257485@qq.com
Country
China
ProdList
950
Advantage
56
Nanjing Redwood Fine Chemical Co., Ltd.
Tel
158-05183379 15805183379
Fax
86-025-58905816
Email
zjp@redwood.com.cn
Country
China
ProdList
217
Advantage
60
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9637
Advantage
58
Sichuan Ampebiochem Co., Ltd.
Tel
028-65294243 13981822079;18682730901
Email
sales@ampebiochem.com
Country
China
ProdList
1000
Advantage
58
Shanghai SE Pharm Co., Ltd
Tel
18112588827
Email
sales4@sepharm.com.cn
Country
China
ProdList
285
Advantage
60
Wuhan Dahua Pharmaceutical Co., Ltd.
Tel
027-59262863 13277907145 3091977954
Fax
027-59420980
Country
China
ProdList
4942
Advantage
58
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10263
Advantage
55
Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9906
Advantage
50
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
14912
Advantage
59
Shanghai HuanChuan Industry Co.,Ltd.
Tel
021-61478794
Fax
021-61478794
Email
sales@hcshhai.com
Country
China
ProdList
9793
Advantage
50
Shanghai Yongye Biotechnology Co., Ltd.
Tel
86-021-61559134 15921386130
Fax
021-55068248
Email
3423497944@qq.com
Country
China
ProdList
8144
Advantage
55
Cool Pharm, Ltd
Tel
021-60455363 18019463053
Fax
50966098
Email
sales@coolpharm.com
Country
China
ProdList
12346
Advantage
58
Tianjing Geneston Bio-tech Co.,Ltd.
Tel
022-60131465 18920720807
Fax
022-58558581
Email
zishan_1986@163.com
Country
China
ProdList
743
Advantage
58
SanoChem (Chengdu) Tech. Co., Ltd.
Tel
28-87999436 02887999436
Fax
QQ:2746983436
Email
sales@sano-chem.com
Country
China
ProdList
3795
Advantage
55
Chengdu jingzhihuacheng Chemical Technology Co., Ltd.
Tel
028-028-37664989 15900794981
Email
jingzhichem@163.com
Country
China
ProdList
537
Advantage
55
Shanghai Send Pharmaceutical Technology Co., Ltd.
Tel
021-58088081 Q2635253576
Fax
QQ3382968513
Email
hailey@shsendpharm.com
Country
China
ProdList
2081
Advantage
55
Zhengzhou Alfachem Co., Ltd.
Tel
0371-53765687 18937137882
Fax
QQ:2885373884
Email
2853979813@qq.com
Country
China
ProdList
7991
Advantage
55
Shanghai GL Peptide Ltd.
Tel
+86-21-61263340; 17609490614 13764994101
Fax
021-61263399
Email
fisherwang@glschina.com
Country
China
ProdList
8258
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Beijing Hechemist Technology CO.,LTD
Tel
18511709189
Fax
010-58043593
Email
sales@hechemist.com
Country
China
ProdList
2835
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Guangdong wengjiang Chemical Reagent Co., Ltd.
Tel
0751-2886750 13927877953
Fax
0751-2886750
Email
3005811397@qq.com
Country
China
ProdList
13305
Advantage
58
Amatek Scientific Co. Ltd.
Tel
0512-56316828
Fax
0512-56316826
Email
info@amateksci.com
Country
China
ProdList
28785
Advantage
58
Hangzhou Molcore Biopharmatech Co.,Ltd
Tel
400-711-5280 86-571-81025280
Fax
86-571-85806285
Email
sales@molcore.com
Country
China
ProdList
9967
Advantage
58
Aikon International Limited
Tel
025-58859352 18068836627
Fax
(5)02557626880
Email
dt3@aikonchem.com
Country
China
ProdList
15493
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 400821072
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
25000
Advantage
58
More
Less

View Lastest Price from Boc-o-methyl-D-serine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Boc-D-Ser(Me)-OH 86123-95-7
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
1000kg
Release date
2021-08-28
Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Boc-D-ser(me)-OH 86123-95-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2023-09-27
Henan Fengda Chemical Co., Ltd
Product
Boc-o-methyl-D-serine 86123-95-7
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-03-22

86123-95-7, Boc-o-methyl-D-serineRelated Search:

BOC-D-TYR(BZL)-OH Boc-D-Serine Boc-O-Benzyl-D-threoninol Boc-o-methyl-D-serine DIMETHYL (BOC-AMINO)MALONATE N-BOC-O-Benzyl-L-serine DIETHYL (BOC-AMINO)MALONATE 4-Boc-3(R)-morpholinecarboxylic acid N-(tert-Butoxycarbonyl)-O-benzyl-D-threonine BOC-D-SER(BZL)-OSU METHYL (R)-(+)-3-(TERT-BUTOXYCARBONYL)-2,2-DIMETHYL-4-OXAZOLIDINECARBOXYLATE (R)-2,2-DIMETHYL-OXAZOLIDINE-3,4-DICARBOXYLIC ACID 3-TERT-BUTYL ESTER BOC-(2R,3R)-2-AMINO-3-ETHOXYBUTANOIC ACID 4-Methyl 2-Tert-Butyloxazolidine-3,4-Dicarboxylate Boc-D-Ser(tBu)-OH BOC-D-THR(TBU)-OH BOC-(2R,3R)-2-AMINO-3-METHYLOXYBUTANOIC ACID BOC-D-MESER(ME)-OH

  • BOC-O-METHYL-D-SERINE
  • D-Serine, N-[(1,1-dimethylethoxy)carbonyl]-O-methyl- (9CI)
  • Boc-O-Methyl-D-serine 97%
  • (2R)-2-{[(tert-butoxy)carbonyl]amino}-3-methoxypropanoic acid
  • (R)-N-Boc-2-aMino-3-Methoxypropionic acid
  • 2-(tert-butoxycarbonylamino)-3-methoxypropanoic acid
  • N-Boc-(D)-O-Methylserine
  • O-Methyl-N-{[(2-Methyl-2-propanyl)oxy]carbonyl}-D-serine
  • Boc-D-Ser(Me)-OH
  • D-Serine, N-[(1,1-diMethylethoxy)carbonyl]-O-Methyl-
  • N-Boc-O-Methyl-D-serine, 98%
  • Boc-N-D-O-methylserine
  • (R)-2-(tert-Butoxycarbonylamino)-3-methoxypropionic acid
  • N-(tert-butoxycarbonyl)-O-methyl-D-serine
  • 86123-95-7
  • Pharmaceuticalintermediates
  • API
  • N-BOC