ChemicalBook > CAS DataBase List > Cyclobutanecarboxylic acid, 3,3-difluoro-, ethyl ester (9CI)

Cyclobutanecarboxylic acid, 3,3-difluoro-, ethyl ester (9CI)

Product Name
Cyclobutanecarboxylic acid, 3,3-difluoro-, ethyl ester (9CI)
CAS No.
681128-38-1
Chemical Name
Cyclobutanecarboxylic acid, 3,3-difluoro-, ethyl ester (9CI)
Synonyms
Ethyl 3,3-difluorocyclobutanecarboxylate;ethyl 3,3-difluorocyclobutane-1-carboxylate;3,3-Difluorocyclobutanecarboxylic acid ethyl ester;Cyclobutanecarboxylic acid, 3,3-difluoro-, ethyl ester;Cyclobutanecarboxylic acid, 3,3-difluoro-, ethyl ester (9CI)
CBNumber
CB61069048
Molecular Formula
C7H10F2O2
Formula Weight
164.15
MOL File
681128-38-1.mol
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Cyclobutanecarboxylic acid, 3,3-difluoro-, ethyl ester (9CI) Property

Boiling point:
155℃
Density 
1.16
Flash point:
47℃
storage temp. 
2-8°C
Appearance
colorless liquid
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Safety

HS Code 
2916200090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
E939740
Product name
Ethyl3,3-Difluorocyclobutanecarboxylate
Packaging
100mg
Price
$60
Updated
2021/12/16
AK Scientific
Product number
7462DF
Product name
Ethyl3,3-difluorocyclobutanecarboxylate
Packaging
1g
Price
$107
Updated
2021/12/16
Activate Scientific
Product number
AS49897
Product name
Ethyl 3,3-difluorocyclobutanecarboxylate
Purity
97%
Packaging
1g
Price
$147
Updated
2021/12/16
Activate Scientific
Product number
AS49897
Product name
Ethyl 3,3-difluorocyclobutanecarboxylate
Purity
97%
Packaging
5G
Price
$386
Updated
2021/12/16
Chemenu
Product number
CM201139
Product name
ethyl3,3-difluorocyclobutane-1-carboxylate
Purity
95%+
Packaging
10g
Price
$449
Updated
2021/12/16
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Cyclobutanecarboxylic acid, 3,3-difluoro-, ethyl ester (9CI) Chemical Properties,Usage,Production

Synthesis

87121-89-9

681128-38-1

The general procedure for the synthesis of ethyl 3,3-difluorocyclobutanecarboxylate from ethyl 3-oxocyclobutanecarboxylate was as follows: to a solution of ethyl 3-oxocyclobutanecarboxylate (2.80 g, 15 mmol) in dichloromethane (100 mL) was added (diethylamino) sulfur trifluoride (4 mL, 29.5 mmol) at -4 °C. The reaction mixture was slowly warmed to room temperature and stirred continuously for 88 hours. Upon completion of the reaction, the mixture was poured into a mixture of sodium carbonate and ice for quenching and stirred for 10 minutes. Subsequently, the reaction mixture was extracted with dichloromethane (3 x 75 mL), the organic phases were combined and dried over sodium sulfate. After filtration, the solvent was evaporated under reduced pressure to give the crude product as an oil. Purification of the crude product by column chromatography (using dichloromethane as eluent) afforded ethyl 3,3-difluorocyclobutanecarboxylate as a yellow oil (2.30 g, 95% yield). The structure of the product was confirmed by 1H-NMR (400 MHz, CDCl3): δ1.25 (t, 3H), 2.60-3.00 (m, 4H), 4.15 (q, 2H).

References

[1] Patent: WO2010/32200, 2010, A1. Location in patent: Page/Page column 147
[2] Patent: US2010/168136, 2010, A1. Location in patent: Page/Page column 33

Cyclobutanecarboxylic acid, 3,3-difluoro-, ethyl ester (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Cyclobutanecarboxylic acid, 3,3-difluoro-, ethyl ester (9CI) manufacturers

Career Henan Chemical Co
Product
Cyclobutanecarboxylic acid, 3,3-difluoro-, ethyl ester (9CI) 681128-38-1
Price
US $2.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
ask
Release date
2019-12-24

681128-38-1, Cyclobutanecarboxylic acid, 3,3-difluoro-, ethyl ester (9CI)Related Search:

Pentadecafluorooctanoic acid Methyl 3,3-difluoro-cyclo... 3,3-Difluorocyclobutanecarboxylic acid 3-aminocyclobutanol(SALTDATA: FREE) Cyclobutanamine, 3,3-difluoro- (9CI) TERT-BUTYL 3,3-DIFLUOROCYCLOBUTANECARBOXYLATE 3,3-DIFLUOROCYCLOBUTANAMINE HYDROCHLORIDE 3-Aminocyclobutanone hydrochloride 3-Aminocyclobutanol hydrochloride (3,3-DIFLUOROCYCLOBUTYL)METHANOL Cyclobutanecarboxylic acid

  • Cyclobutanecarboxylic acid, 3,3-difluoro-, ethyl ester (9CI)
  • Ethyl 3,3-difluorocyclobutanecarboxylate
  • 3,3-Difluorocyclobutanecarboxylic acid ethyl ester
  • Cyclobutanecarboxylic acid, 3,3-difluoro-, ethyl ester
  • ethyl 3,3-difluorocyclobutane-1-carboxylate
  • 681128-38-1
  • HALIDE