Cyclobutanecarboxylic acid, 3,3-difluoro-, ethyl ester (9CI)
- Product Name
- Cyclobutanecarboxylic acid, 3,3-difluoro-, ethyl ester (9CI)
- CAS No.
- 681128-38-1
- Chemical Name
- Cyclobutanecarboxylic acid, 3,3-difluoro-, ethyl ester (9CI)
- Synonyms
- Ethyl 3,3-difluorocyclobutanecarboxylate;ethyl 3,3-difluorocyclobutane-1-carboxylate;3,3-Difluorocyclobutanecarboxylic acid ethyl ester;Cyclobutanecarboxylic acid, 3,3-difluoro-, ethyl ester;Cyclobutanecarboxylic acid, 3,3-difluoro-, ethyl ester (9CI)
- CBNumber
- CB61069048
- Molecular Formula
- C7H10F2O2
- Formula Weight
- 164.15
- MOL File
- 681128-38-1.mol
Cyclobutanecarboxylic acid, 3,3-difluoro-, ethyl ester (9CI) Property
- Boiling point:
- 155℃
- Density
- 1.16
- Flash point:
- 47℃
- storage temp.
- 2-8°C
- Appearance
- colorless liquid
Safety
- HS Code
- 2916200090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E939740
- Product name
- Ethyl3,3-Difluorocyclobutanecarboxylate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 7462DF
- Product name
- Ethyl3,3-difluorocyclobutanecarboxylate
- Packaging
- 1g
- Price
- $107
- Updated
- 2021/12/16
- Product number
- AS49897
- Product name
- Ethyl 3,3-difluorocyclobutanecarboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $147
- Updated
- 2021/12/16
- Product number
- AS49897
- Product name
- Ethyl 3,3-difluorocyclobutanecarboxylate
- Purity
- 97%
- Packaging
- 5G
- Price
- $386
- Updated
- 2021/12/16
- Product number
- CM201139
- Product name
- ethyl3,3-difluorocyclobutane-1-carboxylate
- Purity
- 95%+
- Packaging
- 10g
- Price
- $449
- Updated
- 2021/12/16
Cyclobutanecarboxylic acid, 3,3-difluoro-, ethyl ester (9CI) Chemical Properties,Usage,Production
Synthesis
87121-89-9
681128-38-1
The general procedure for the synthesis of ethyl 3,3-difluorocyclobutanecarboxylate from ethyl 3-oxocyclobutanecarboxylate was as follows: to a solution of ethyl 3-oxocyclobutanecarboxylate (2.80 g, 15 mmol) in dichloromethane (100 mL) was added (diethylamino) sulfur trifluoride (4 mL, 29.5 mmol) at -4 °C. The reaction mixture was slowly warmed to room temperature and stirred continuously for 88 hours. Upon completion of the reaction, the mixture was poured into a mixture of sodium carbonate and ice for quenching and stirred for 10 minutes. Subsequently, the reaction mixture was extracted with dichloromethane (3 x 75 mL), the organic phases were combined and dried over sodium sulfate. After filtration, the solvent was evaporated under reduced pressure to give the crude product as an oil. Purification of the crude product by column chromatography (using dichloromethane as eluent) afforded ethyl 3,3-difluorocyclobutanecarboxylate as a yellow oil (2.30 g, 95% yield). The structure of the product was confirmed by 1H-NMR (400 MHz, CDCl3): δ1.25 (t, 3H), 2.60-3.00 (m, 4H), 4.15 (q, 2H).
References
[1] Patent: WO2010/32200, 2010, A1. Location in patent: Page/Page column 147
[2] Patent: US2010/168136, 2010, A1. Location in patent: Page/Page column 33
Cyclobutanecarboxylic acid, 3,3-difluoro-, ethyl ester (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
Cyclobutanecarboxylic acid, 3,3-difluoro-, ethyl ester (9CI) Suppliers
- Tel
- --
- Fax
- --
- contact@achemica.com
- Country
- Switzerland
- ProdList
- 6155
- Advantage
- 50
View Lastest Price from Cyclobutanecarboxylic acid, 3,3-difluoro-, ethyl ester (9CI) manufacturers
- Product
- Cyclobutanecarboxylic acid, 3,3-difluoro-, ethyl ester (9CI) 681128-38-1
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- ask
- Release date
- 2019-12-24